TEKT1_MOUSE
ID TEKT1_MOUSE Reviewed; 418 AA.
AC Q9DAJ2;
DT 08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Tektin-1;
GN Name=Tekt1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms
CC filamentous polymers in the walls of ciliary and flagellar
CC microtubules. {ECO:0000250|UniProtKB:Q32KZ9}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:Q32KZ9}. Cytoplasm, cytoskeleton, flagellum
CC axoneme {ECO:0000250|UniProtKB:Q32KZ9}.
CC -!- SIMILARITY: Belongs to the tektin family. {ECO:0000305}.
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DR EMBL; AK005801; BAB24244.1; -; mRNA.
DR CCDS; CCDS36215.1; -.
DR RefSeq; NP_001268935.1; NM_001282006.1.
DR RefSeq; NP_001268936.1; NM_001282007.1.
DR RefSeq; NP_035699.2; NM_011569.3.
DR AlphaFoldDB; Q9DAJ2; -.
DR SMR; Q9DAJ2; -.
DR STRING; 10090.ENSMUSP00000021155; -.
DR PhosphoSitePlus; Q9DAJ2; -.
DR REPRODUCTION-2DPAGE; Q9DAJ2; -.
DR MaxQB; Q9DAJ2; -.
DR PaxDb; Q9DAJ2; -.
DR PRIDE; Q9DAJ2; -.
DR ProteomicsDB; 262864; -.
DR Antibodypedia; 23852; 143 antibodies from 25 providers.
DR DNASU; 21689; -.
DR Ensembl; ENSMUST00000021155; ENSMUSP00000021155; ENSMUSG00000020799.
DR Ensembl; ENSMUST00000108502; ENSMUSP00000104142; ENSMUSG00000020799.
DR Ensembl; ENSMUST00000108503; ENSMUSP00000104143; ENSMUSG00000020799.
DR GeneID; 21689; -.
DR KEGG; mmu:21689; -.
DR UCSC; uc007jyt.2; mouse.
DR CTD; 83659; -.
DR MGI; MGI:1333819; Tekt1.
DR VEuPathDB; HostDB:ENSMUSG00000020799; -.
DR eggNOG; KOG2685; Eukaryota.
DR GeneTree; ENSGT00950000182894; -.
DR HOGENOM; CLU_033588_2_2_1; -.
DR InParanoid; Q9DAJ2; -.
DR OMA; EPLHITQ; -.
DR OrthoDB; 581072at2759; -.
DR PhylomeDB; Q9DAJ2; -.
DR TreeFam; TF320754; -.
DR BioGRID-ORCS; 21689; 4 hits in 72 CRISPR screens.
DR ChiTaRS; Tekt1; mouse.
DR PRO; PR:Q9DAJ2; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9DAJ2; protein.
DR Bgee; ENSMUSG00000020799; Expressed in spermatid and 122 other tissues.
DR ExpressionAtlas; Q9DAJ2; baseline and differential.
DR Genevisible; Q9DAJ2; MM.
DR GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR GO; GO:0015630; C:microtubule cytoskeleton; IDA:MGI.
DR GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR GO; GO:0060294; P:cilium movement involved in cell motility; IBA:GO_Central.
DR InterPro; IPR000435; Tektin.
DR PANTHER; PTHR19960; PTHR19960; 1.
DR PRINTS; PR00511; TEKTIN.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton; Flagellum;
KW Microtubule; Reference proteome.
FT CHAIN 1..418
FT /note="Tektin-1"
FT /id="PRO_0000184563"
FT COILED 20..107
FT /evidence="ECO:0000255"
FT COILED 134..177
FT /evidence="ECO:0000255"
FT COILED 266..308
FT /evidence="ECO:0000255"
FT COILED 332..383
FT /evidence="ECO:0000255"
SQ SEQUENCE 418 AA; 48641 MW; 1EA101615FEB527B CRC64;
MAKLLQSPPR FLPEEWYIAN KSQYHRAEAQ RSQSERLVAE SQRLVEEIEK TTRKSQSDVN
KKLEQRLEEV RFWKKELDDK LEQLVNQTDD LLTYKTRLER SLESYKEPLH ITEKCLEYRE
KRVGIDLVHD VVEQELQKEA DIIHGVMNLL IRTLEESTEQ IRLNRSAKYN LEKDLRDKFT
AITIDDVCFS LNNNSPNINF SEKVVRIEPN SVSLEDWLDF SNANVEKADK QLNNSTALKT
LVDQILSQTA NDLRRQCEVV DEAFINGLKE TKDARNKLAD HLAKVMEEIA SQEKNIMALE
NAITQQEGPA KVAHTRLETR THRPNVELCR DIAQYRLIKE IQEINHNVAR LKETLAQAQT
QLKALYRRQL ALQEEIQVKE NTIYIDQVLC MEMRKSIPPR DGDDHGAWEG GIRAEAIC
