ID   TEKT2_BOVIN             Reviewed;         430 AA.
AC   Q2T9Q6;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Tektin-2;
GN   Name=TEKT2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0007744|PDB:7RRO}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS), FUNCTION, SUBCELLULAR
RP   LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=34715025; DOI=10.1016/j.cell.2021.10.007;
RA   Gui M., Farley H., Anujan P., Anderson J.R., Maxwell D.W., Whitchurch J.B.,
RA   Botsch J.J., Qiu T., Meleppattu S., Singh S.K., Zhang Q., Thompson J.,
RA   Lucas J.S., Bingle C.D., Norris D.P., Roy S., Brown A.;
RT   "De novo identification of mammalian ciliary motility proteins using cryo-
RT   EM.";
RL   Cell 184:5791-5806.e19(2021).
CC   -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC       doublet microtubules (DMTs) in cilia and flagellar axoneme
CC       (PubMed:34715025). Plays a key role in the assembly or attachment of
CC       the inner dynein arm to microtubules in sperm flagella and tracheal
CC       cilia (By similarity). Forms filamentous polymers in the walls of
CC       ciliary and flagellar microtubules (PubMed:34715025).
CC       {ECO:0000250|UniProtKB:Q922G7, ECO:0000269|PubMed:34715025}.
CC   -!- SUBUNIT: May interact with CCDC172. {ECO:0000250|UniProtKB:Q922G7}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000269|PubMed:34715025}. Cytoplasm, cytoskeleton, flagellum
CC       axoneme {ECO:0000250|UniProtKB:Q922G7}. Cytoplasm, cytoskeleton,
CC       microtubule organizing center {ECO:0000250|UniProtKB:Q922G7}.
CC       Note=Colocalized with CCDC172 at the perinuclear region.
CC       {ECO:0000250|UniProtKB:Q922G7}.
CC   -!- TISSUE SPECIFICITY: Expressed in trachea multiciliated cells.
CC       {ECO:0000269|PubMed:34715025}.
CC   -!- PTM: Tyrosine phosphorylated. {ECO:0000250|UniProtKB:Q1W6C3}.
CC   -!- SIMILARITY: Belongs to the tektin family. {ECO:0000305}.
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DR   EMBL; BC111312; AAI11313.1; -; mRNA.
DR   RefSeq; NP_001033192.1; NM_001038103.2.
DR   PDB; 7RRO; EM; 3.40 A; B0/B1/B2/B3/B4/B5/B6/B7/B8/B9=1-430.
DR   PDBsum; 7RRO; -.
DR   AlphaFoldDB; Q2T9Q6; -.
DR   SMR; Q2T9Q6; -.
DR   STRING; 9913.ENSBTAP00000028947; -.
DR   PaxDb; Q2T9Q6; -.
DR   PRIDE; Q2T9Q6; -.
DR   Ensembl; ENSBTAT00000028947; ENSBTAP00000028947; ENSBTAG00000021714.
DR   GeneID; 514463; -.
DR   KEGG; bta:514463; -.
DR   CTD; 27285; -.
DR   VEuPathDB; HostDB:ENSBTAG00000021714; -.
DR   VGNC; VGNC:35737; TEKT2.
DR   eggNOG; KOG2685; Eukaryota.
DR   GeneTree; ENSGT00950000182894; -.
DR   HOGENOM; CLU_033588_0_0_1; -.
DR   InParanoid; Q2T9Q6; -.
DR   OMA; FDHRGKM; -.
DR   OrthoDB; 581072at2759; -.
DR   TreeFam; TF320754; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000021714; Expressed in spermatid and 81 other tissues.
DR   ExpressionAtlas; Q2T9Q6; baseline.
DR   GO; GO:0005879; C:axonemal microtubule; IDA:UniProtKB.
DR   GO; GO:0015630; C:microtubule cytoskeleton; IBA:GO_Central.
DR   GO; GO:0005815; C:microtubule organizing center; ISS:UniProtKB.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR   GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR   GO; GO:0060294; P:cilium movement involved in cell motility; IBA:GO_Central.
DR   GO; GO:0030317; P:flagellated sperm motility; IEA:Ensembl.
DR   GO; GO:0036159; P:inner dynein arm assembly; IEA:Ensembl.
DR   InterPro; IPR000435; Tektin.
DR   PANTHER; PTHR19960; PTHR19960; 1.
DR   PRINTS; PR00511; TEKTIN.
PE   1: Evidence at protein level;
KW   3D-structure; Cell projection; Cilium; Coiled coil; Cytoplasm;
KW   Cytoskeleton; Flagellum; Microtubule; Phosphoprotein; Reference proteome.
FT   CHAIN           1..430
FT                   /note="Tektin-2"
FT                   /id="PRO_0000261173"
FT   COILED          81..162
FT                   /evidence="ECO:0000255"
FT   COILED          265..379
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   430 AA;  49886 MW;  842EB284B3581001 CRC64;
     MATLSVKPSP RFRLPDWQTN SYLLSTNAER QRDASHQIRQ EARVLRNETN NQTIWDEHDN
     RTRLAERIDT VSRWKEMLDK CLTDLDAEID ALAQMKESAE QNLQAKNLPL DVAIECLTLR
     ESRRDIDVVK DPVEEELHKE VEVIEATKKA LQQKISQAFE KLFLLQEARQ RLNSDHRGKM
     ETLDIDRGCL SLNLTSPNIS LKINPTRVPN GSTSLQQWDD LSRFNKDHGE AEMKKAIELR
     EAIALTIAET NNELEAQRVA TEFAFRKRLR EMEKLYSELK WQEKNTLEEI AELHEDIRHL
     EEDLRRKLQN LKLCHTRLEA RTYRPNVELC RDQAQYGLTD EVHQLEATIA ALKQKLAQAQ
     DALDALYKHL ARLQADIACK ANSMLLDTKC MDTRRKLTVP AEKFVPEVDT FTRTTNRTLS
     PLKTCQLELA