ID   TEKT2_MACFA             Reviewed;         430 AA.
AC   Q4R5V1;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Tektin-2;
GN   Name=TEKT2; ORFNames=QtsA-20636;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC       doublet microtubules (DMTs) in cilia and flagellar axoneme. Plays a key
CC       role in the assembly or attachment of the inner dynein arm to
CC       microtubules in sperm flagella and tracheal cilia. Forms filamentous
CC       polymers in the walls of ciliary and flagellar microtubules.
CC       {ECO:0000250|UniProtKB:Q922G7}.
CC   -!- SUBUNIT: May interact with CCDC172. {ECO:0000250|UniProtKB:Q922G7}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:Q922G7}. Cytoplasm, cytoskeleton, flagellum
CC       axoneme {ECO:0000250|UniProtKB:Q922G7}. Cytoplasm, cytoskeleton,
CC       microtubule organizing center {ECO:0000250|UniProtKB:Q922G7}.
CC       Note=Colocalized with CCDC172 at the perinuclear region.
CC       {ECO:0000250|UniProtKB:Q922G7}.
CC   -!- PTM: Tyrosine phosphorylated. {ECO:0000250|UniProtKB:Q1W6C3}.
CC   -!- SIMILARITY: Belongs to the tektin family. {ECO:0000305}.
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DR   EMBL; AB169442; BAE01524.1; -; mRNA.
DR   RefSeq; NP_001271821.1; NM_001284892.1.
DR   AlphaFoldDB; Q4R5V1; -.
DR   SMR; Q4R5V1; -.
DR   STRING; 9541.XP_005544033.1; -.
DR   GeneID; 101865150; -.
DR   CTD; 27285; -.
DR   eggNOG; KOG2685; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR   GO; GO:0005815; C:microtubule organizing center; ISS:UniProtKB.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR   GO; GO:0060294; P:cilium movement involved in cell motility; IEA:InterPro.
DR   InterPro; IPR000435; Tektin.
DR   PANTHER; PTHR19960; PTHR19960; 1.
DR   PRINTS; PR00511; TEKTIN.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton; Flagellum;
KW   Microtubule; Phosphoprotein; Reference proteome.
FT   CHAIN           1..430
FT                   /note="Tektin-2"
FT                   /id="PRO_0000261168"
FT   COILED          82..160
FT                   /evidence="ECO:0000255"
FT   COILED          273..379
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   430 AA;  49631 MW;  CE52302F488896CE CRC64;
     MATLSVKPSQ RFQLPDWHTN SYLLSTNAQL QRDASHQIRQ EARVLRNETN NQTIWDEHDN
     RTRLVERIDT VNRWKEMLDK CLTDLDAEID ALTQMKDSAG QNLQAKNLPL DVAIECLTLR
     ESRRDIDVVK DPVEDELHKE VEVIEATKKA LQQKVSQAFE HLCLLQEVRQ QLNSDHRGKM
     ETLEIDRGCL SLNLRSPNIS LKVDPTRVPD GSTTLQQWDD FSQFNKDRGE AEMKAATELR
     EAIALTIAET NNELEAQRVA TEFAFRKRLR EMEKVYSELK WQEKNTLEEI AELQEDIRHL
     EEDLRTKFLS LKLSHTRLEA RTYRPNVELC RDQAQYGLTD EVHQLEATIA ALKQKLAQAQ
     DALDALYKHL ARLQADIACK ANSMLLDTKC MDTRRKLTVP AEKFVPEVDT FTRTTNSTLS
     PLKSCQLELA