ID   TEKT2_RAT               Reviewed;         430 AA.
AC   Q6AYM2;
DT   09-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Tektin-2;
DE   AltName: Full=Tektin-t;
DE   AltName: Full=Testicular tektin;
GN   Name=Tekt2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC       doublet microtubules (DMTs) in cilia and flagellar axoneme. Plays a key
CC       role in the assembly or attachment of the inner dynein arm to
CC       microtubules in sperm flagella and tracheal cilia. Forms filamentous
CC       polymers in the walls of ciliary and flagellar microtubules.
CC       {ECO:0000250|UniProtKB:Q922G7}.
CC   -!- SUBUNIT: May interact with CCDC172. {ECO:0000250|UniProtKB:Q922G7}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:Q922G7}. Cytoplasm, cytoskeleton, flagellum
CC       axoneme {ECO:0000250|UniProtKB:Q922G7}. Cytoplasm, cytoskeleton,
CC       microtubule organizing center {ECO:0000250|UniProtKB:Q922G7}.
CC       Note=Colocalized with CCDC172 at the perinuclear region.
CC       {ECO:0000250|UniProtKB:Q922G7}.
CC   -!- PTM: Tyrosine phosphorylated. {ECO:0000250|UniProtKB:Q1W6C3}.
CC   -!- SIMILARITY: Belongs to the tektin family. {ECO:0000305}.
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DR   EMBL; BC078990; AAH78990.1; -; mRNA.
DR   RefSeq; NP_001011977.1; NM_001011977.1.
DR   RefSeq; XP_006238922.1; XM_006238860.1.
DR   RefSeq; XP_006238923.1; XM_006238861.3.
DR   AlphaFoldDB; Q6AYM2; -.
DR   SMR; Q6AYM2; -.
DR   BioGRID; 255921; 1.
DR   STRING; 10116.ENSRNOP00000014721; -.
DR   PhosphoSitePlus; Q6AYM2; -.
DR   PaxDb; Q6AYM2; -.
DR   PRIDE; Q6AYM2; -.
DR   Ensembl; ENSRNOT00000014721; ENSRNOP00000014721; ENSRNOG00000011033.
DR   GeneID; 298532; -.
DR   KEGG; rno:298532; -.
DR   UCSC; RGD:1311065; rat.
DR   CTD; 27285; -.
DR   RGD; 1311065; Tekt2.
DR   eggNOG; KOG2685; Eukaryota.
DR   GeneTree; ENSGT00950000182894; -.
DR   HOGENOM; CLU_033588_0_0_1; -.
DR   InParanoid; Q6AYM2; -.
DR   OMA; FDHRGKM; -.
DR   OrthoDB; 581072at2759; -.
DR   PhylomeDB; Q6AYM2; -.
DR   TreeFam; TF320754; -.
DR   PRO; PR:Q6AYM2; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Bgee; ENSRNOG00000011033; Expressed in testis and 7 other tissues.
DR   Genevisible; Q6AYM2; RN.
DR   GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR   GO; GO:0015630; C:microtubule cytoskeleton; IBA:GO_Central.
DR   GO; GO:0005815; C:microtubule organizing center; ISS:UniProtKB.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR   GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR   GO; GO:0060294; P:cilium movement involved in cell motility; IBA:GO_Central.
DR   GO; GO:0030317; P:flagellated sperm motility; ISO:RGD.
DR   GO; GO:0036159; P:inner dynein arm assembly; ISO:RGD.
DR   InterPro; IPR000435; Tektin.
DR   PANTHER; PTHR19960; PTHR19960; 1.
DR   PRINTS; PR00511; TEKTIN.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton; Flagellum;
KW   Microtubule; Phosphoprotein; Reference proteome.
FT   CHAIN           1..430
FT                   /note="Tektin-2"
FT                   /id="PRO_0000184567"
FT   COILED          75..162
FT                   /evidence="ECO:0000255"
FT   COILED          226..380
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   430 AA;  50296 MW;  04503F95998FC6BA CRC64;
     MATLSLKPSQ RYRLSDWLTN SYLLSTNAER QRDASHQIRQ EARILRNETN NQTVWDEHDN
     RTRLAERIDT VNRWKEMLDK CLTDLDAEID SLTQAKESVE QSLQAKNLPL DVAIECLTLR
     ESRRDIDVVK DPVEEELMKE VEVIEATKKV LQEKISQAFQ HLCLLQEIRQ QLNSDHRDKM
     ETLEIDRGCL SLNLTAPNLS LKVNPTRVPK DSTTLQEWDD FTRFNKNRAD TEMKASIELR
     ETIALAIAQT NNELEAQRVA TEFTFRKRLR EMESLYSELK WQEKNTLEEI AELQADIRRL
     EEDLRRKMMN LKLAHTRLES RTYRPNVELC RDQTQYGLID EVHQLEATIS IMKQKLAQTQ
     DALDALFKHL ARIQADIACK TNTMLLDTKC MDIRRKLTVP AEKFVPQVDT FTRTTNRTLS
     PLKTCQLELN