ID   TEKT3_MESAU             Reviewed;         109 AA.
AC   P86230;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   15-JUN-2010, sequence version 1.
DT   03-AUG-2022, entry version 28.
DE   RecName: Full=Tektin-3 {ECO:0000250|UniProtKB:Q6X6Z7};
DE   Flags: Fragments;
GN   Name=TEKT3 {ECO:0000250|UniProtKB:Q6X6Z7};
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036;
RN   [1]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=20400973; DOI=10.1038/aja.2010.19;
RA   Kameshwari D.B., Bhande S., Sundaram C.S., Kota V., Siva A.B., Shivaji S.;
RT   "Glucose-regulated protein precursor (GRP78) and tumor rejection antigen
RT   (GP96) are unique to hamster caput epididymal spermatozoa.";
RL   Asian J. Androl. 12:344-355(2010).
CC   -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC       doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms
CC       filamentous polymers in the walls of ciliary and flagellar microtubules
CC       (By similarity). Required for normal sperm mobility (By similarity).
CC       {ECO:0000250|UniProtKB:A6H782, ECO:0000250|UniProtKB:Q6X6Z7}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:A6H782}. Cell projection, cilium, flagellum
CC       {ECO:0000250|UniProtKB:A6H782, ECO:0000250|UniProtKB:Q4V8G8}.
CC       Cytoplasmic vesicle, secretory vesicle, acrosome outer membrane
CC       {ECO:0000250|UniProtKB:A6H782, ECO:0000250|UniProtKB:Q4V8G8};
CC       Peripheral membrane protein {ECO:0000250|UniProtKB:Q4V8G8}. Note=In the
CC       sperm flagellum, localizes to the periaxonemal region where it
CC       associates with the mitochondrial sheath and outer dense fibers (By
CC       similarity). Not detected in the central axonemal region of the
CC       flagellum (By similarity). Associates with the acrosome membrane in the
CC       equatorial segment of the sperm head (By similarity). Also detected
CC       just below the plasma membrane in the post-acrosomal region where it
CC       might localize to the postacrosomal dense lamina (By similarity).
CC       However, other studies report little or no expression in the
CC       postacrosomal region (By similarity). Translocates from the
CC       postacrosomal region to the equatorial segment after sperm activation
CC       (By similarity). Retained in the postacromal region, but not the
CC       equatorial segment, following the acrosome reaction (By similarity).
CC       Some studies report strong expression in the anterior cap region (By
CC       similarity). However, other studies report little or no expression in
CC       the acrosomal cap (By similarity). {ECO:0000250|UniProtKB:A6H782,
CC       ECO:0000250|UniProtKB:Q4V8G8}.
CC   -!- PTM: N- and O-glycosylated. {ECO:0000250|UniProtKB:A6H782}.
CC   -!- PTM: May be proteolytically processed during the epididymal transit of
CC       spermatozoa. {ECO:0000250|UniProtKB:A6H782}.
CC   -!- SIMILARITY: Belongs to the tektin family. {ECO:0000255}.
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DR   AlphaFoldDB; P86230; -.
DR   SMR; P86230; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0002081; C:outer acrosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0060294; P:cilium movement involved in cell motility; IEA:InterPro.
DR   InterPro; IPR000435; Tektin.
DR   PANTHER; PTHR19960; PTHR19960; 2.
PE   1: Evidence at protein level;
KW   Cell projection; Cilium; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton;
KW   Flagellum; Membrane; Reference proteome.
FT   CHAIN           <1..>109
FT                   /note="Tektin-3"
FT                   /id="PRO_0000394753"
FT   NON_CONS        8..9
FT                   /evidence="ECO:0000305"
FT   NON_CONS        39..40
FT                   /evidence="ECO:0000305"
FT   NON_CONS        47..48
FT                   /evidence="ECO:0000305"
FT   NON_CONS        56..57
FT                   /evidence="ECO:0000305"
FT   NON_CONS        66..67
FT                   /evidence="ECO:0000305"
FT   NON_CONS        99..100
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
FT   NON_TER         109
SQ   SEQUENCE   109 AA;  13046 MW;  549FDD0FF72D1A29 CRC64;
     YTPDDWYRLI QDKYQQIRKT QADSTQNLGE RVNDIAFWKE CLFHREKAIA QLASDRTRRP
     NIELCRLVNE VYEVDETIQT LQQRLRDSED TLQSLAHTKA NTLYIDQEK