TEKT4_HUMAN
ID TEKT4_HUMAN Reviewed; 435 AA.
AC Q8WW24;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Tektin-4;
GN Name=TEKT4 {ECO:0000312|HGNC:HGNC:31012};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP VARIANT [LARGE SCALE ANALYSIS] SER-272.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=17244819; DOI=10.1096/fj.06-7035com;
RA Roy A., Lin Y.N., Agno J.E., DeMayo F.J., Matzuk M.M.;
RT "Absence of tektin 4 causes asthenozoospermia and subfertility in male
RT mice.";
RL FASEB J. 21:1013-1025(2007).
CC -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms
CC filamentous polymers in the walls of ciliary and flagellar microtubules
CC (By similarity). Contributes to normal sperm motility (By similarity).
CC {ECO:0000250|UniProtKB:Q2TA38, ECO:0000250|UniProtKB:Q6X6Z7}.
CC -!- INTERACTION:
CC Q8WW24; Q8NC06-3: ACBD4; NbExp=3; IntAct=EBI-750487, EBI-12811089;
CC Q8WW24; Q9ULX6: AKAP8L; NbExp=3; IntAct=EBI-750487, EBI-357530;
CC Q8WW24; P13196: ALAS1; NbExp=6; IntAct=EBI-750487, EBI-3905054;
CC Q8WW24; Q9Y4X0-3: AMMECR1; NbExp=3; IntAct=EBI-750487, EBI-12823597;
CC Q8WW24; Q3KP44: ANKRD55; NbExp=3; IntAct=EBI-750487, EBI-14493093;
CC Q8WW24; Q03989: ARID5A; NbExp=3; IntAct=EBI-750487, EBI-948603;
CC Q8WW24; A9UGY9: ATG5; NbExp=3; IntAct=EBI-750487, EBI-10175276;
CC Q8WW24; Q9H1Y0: ATG5; NbExp=6; IntAct=EBI-750487, EBI-1047414;
CC Q8WW24; P41182: BCL6; NbExp=3; IntAct=EBI-750487, EBI-765407;
CC Q8WW24; Q9H2G9: BLZF1; NbExp=3; IntAct=EBI-750487, EBI-2548012;
CC Q8WW24; Q9H5F2: C11orf1; NbExp=3; IntAct=EBI-750487, EBI-718615;
CC Q8WW24; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-750487, EBI-8643161;
CC Q8WW24; Q9GZU7: CTDSP1; NbExp=3; IntAct=EBI-750487, EBI-751587;
CC Q8WW24; Q96D03: DDIT4L; NbExp=3; IntAct=EBI-750487, EBI-742054;
CC Q8WW24; Q5JST6: EFHC2; NbExp=3; IntAct=EBI-750487, EBI-2349927;
CC Q8WW24; O00167-2: EYA2; NbExp=3; IntAct=EBI-750487, EBI-12807776;
CC Q8WW24; Q7Z4H9: FAM220A; NbExp=3; IntAct=EBI-750487, EBI-12871772;
CC Q8WW24; P15976-2: GATA1; NbExp=5; IntAct=EBI-750487, EBI-9090198;
CC Q8WW24; Q86YR5-3: GPSM1; NbExp=3; IntAct=EBI-750487, EBI-10261098;
CC Q8WW24; Q13322-4: GRB10; NbExp=3; IntAct=EBI-750487, EBI-12353035;
CC Q8WW24; Q14687: GSE1; NbExp=5; IntAct=EBI-750487, EBI-372619;
CC Q8WW24; P08631-2: HCK; NbExp=3; IntAct=EBI-750487, EBI-9834454;
CC Q8WW24; P31943: HNRNPH1; NbExp=3; IntAct=EBI-750487, EBI-351590;
CC Q8WW24; P52272: HNRNPM; NbExp=3; IntAct=EBI-750487, EBI-486809;
CC Q8WW24; P49639: HOXA1; NbExp=3; IntAct=EBI-750487, EBI-740785;
CC Q8WW24; P09067: HOXB5; NbExp=3; IntAct=EBI-750487, EBI-3893317;
CC Q8WW24; P31273: HOXC8; NbExp=3; IntAct=EBI-750487, EBI-1752118;
CC Q8WW24; Q9UKT9: IKZF3; NbExp=7; IntAct=EBI-750487, EBI-747204;
CC Q8WW24; Q0VD86: INCA1; NbExp=3; IntAct=EBI-750487, EBI-6509505;
CC Q8WW24; Q5T749: KPRP; NbExp=3; IntAct=EBI-750487, EBI-10981970;
CC Q8WW24; P05783: KRT18; NbExp=3; IntAct=EBI-750487, EBI-297888;
CC Q8WW24; O76011: KRT34; NbExp=5; IntAct=EBI-750487, EBI-1047093;
CC Q8WW24; Q92764: KRT35; NbExp=3; IntAct=EBI-750487, EBI-1058674;
CC Q8WW24; O95678: KRT75; NbExp=3; IntAct=EBI-750487, EBI-2949715;
CC Q8WW24; O43790: KRT86; NbExp=3; IntAct=EBI-750487, EBI-9996498;
CC Q8WW24; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-750487, EBI-1052037;
CC Q8WW24; Q3SY46: KRTAP13-3; NbExp=5; IntAct=EBI-750487, EBI-10241252;
CC Q8WW24; Q8IUB9: KRTAP19-1; NbExp=5; IntAct=EBI-750487, EBI-12811111;
CC Q8WW24; Q3LHN2: KRTAP19-2; NbExp=3; IntAct=EBI-750487, EBI-12196745;
CC Q8WW24; Q3LI70: KRTAP19-6; NbExp=3; IntAct=EBI-750487, EBI-12805508;
CC Q8WW24; Q6PEX3: KRTAP26-1; NbExp=3; IntAct=EBI-750487, EBI-3957672;
CC Q8WW24; Q3LI66: KRTAP6-2; NbExp=5; IntAct=EBI-750487, EBI-11962084;
CC Q8WW24; Q8IUC3: KRTAP7-1; NbExp=3; IntAct=EBI-750487, EBI-18394498;
CC Q8WW24; Q14847-2: LASP1; NbExp=3; IntAct=EBI-750487, EBI-9088686;
CC Q8WW24; Q9NZU5: LMCD1; NbExp=3; IntAct=EBI-750487, EBI-5774016;
CC Q8WW24; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-750487, EBI-739832;
CC Q8WW24; P43358: MAGEA4; NbExp=7; IntAct=EBI-750487, EBI-743122;
CC Q8WW24; Q1RN33: MAGEA4; NbExp=3; IntAct=EBI-750487, EBI-10194128;
CC Q8WW24; Q02080: MEF2B; NbExp=3; IntAct=EBI-750487, EBI-6427785;
CC Q8WW24; Q5JXC2: MIIP; NbExp=3; IntAct=EBI-750487, EBI-2801965;
CC Q8WW24; Q6PF18: MORN3; NbExp=3; IntAct=EBI-750487, EBI-9675802;
CC Q8WW24; Q8TDC0: MYOZ3; NbExp=3; IntAct=EBI-750487, EBI-5662487;
CC Q8WW24; P60323-2: NANOS3; NbExp=3; IntAct=EBI-750487, EBI-18012223;
CC Q8WW24; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-750487, EBI-10271199;
CC Q8WW24; Q13285: NR5A1; NbExp=3; IntAct=EBI-750487, EBI-874629;
CC Q8WW24; Q92824-2: PCSK5; NbExp=3; IntAct=EBI-750487, EBI-11956269;
CC Q8WW24; Q9UIL8: PHF11; NbExp=3; IntAct=EBI-750487, EBI-2861403;
CC Q8WW24; Q99959-2: PKP2; NbExp=3; IntAct=EBI-750487, EBI-10987518;
CC Q8WW24; Q9UPG8: PLAGL2; NbExp=3; IntAct=EBI-750487, EBI-2876622;
CC Q8WW24; Q8WUT1: POLDIP3; NbExp=3; IntAct=EBI-750487, EBI-10276663;
CC Q8WW24; Q96KQ4: PPP1R13B; NbExp=3; IntAct=EBI-750487, EBI-1105153;
CC Q8WW24; Q7Z5V6-2: PPP1R32; NbExp=6; IntAct=EBI-750487, EBI-12000762;
CC Q8WW24; Q9GZV8: PRDM14; NbExp=6; IntAct=EBI-750487, EBI-3957793;
CC Q8WW24; Q9NQX0: PRDM6; NbExp=3; IntAct=EBI-750487, EBI-11320284;
CC Q8WW24; O75360: PROP1; NbExp=3; IntAct=EBI-750487, EBI-9027467;
CC Q8WW24; P25786: PSMA1; NbExp=3; IntAct=EBI-750487, EBI-359352;
CC Q8WW24; Q03431: PTH1R; NbExp=3; IntAct=EBI-750487, EBI-2860297;
CC Q8WW24; Q9BTL3: RAMAC; NbExp=3; IntAct=EBI-750487, EBI-744023;
CC Q8WW24; P10276: RARA; NbExp=4; IntAct=EBI-750487, EBI-413374;
CC Q8WW24; P10276-2: RARA; NbExp=3; IntAct=EBI-750487, EBI-10197061;
CC Q8WW24; Q5RL73: RBM48; NbExp=3; IntAct=EBI-750487, EBI-473821;
CC Q8WW24; Q6P9E2: RECK; NbExp=6; IntAct=EBI-750487, EBI-10253121;
CC Q8WW24; Q8HWS3: RFX6; NbExp=3; IntAct=EBI-750487, EBI-746118;
CC Q8WW24; Q9BVN2: RUSC1; NbExp=5; IntAct=EBI-750487, EBI-6257312;
CC Q8WW24; Q14524-3: SCN5A; NbExp=3; IntAct=EBI-750487, EBI-14276801;
CC Q8WW24; P12236: SLC25A6; NbExp=3; IntAct=EBI-750487, EBI-356254;
CC Q8WW24; P84022: SMAD3; NbExp=3; IntAct=EBI-750487, EBI-347161;
CC Q8WW24; Q8NCR6: SMRP1; NbExp=3; IntAct=EBI-750487, EBI-10269322;
CC Q8WW24; Q8WXH5: SOCS4; NbExp=3; IntAct=EBI-750487, EBI-3942425;
CC Q8WW24; Q6RVD6: SPATA8; NbExp=3; IntAct=EBI-750487, EBI-8635958;
CC Q8WW24; Q9H0A9-2: SPATC1L; NbExp=3; IntAct=EBI-750487, EBI-11995806;
CC Q8WW24; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-750487, EBI-742688;
CC Q8WW24; O43463: SUV39H1; NbExp=3; IntAct=EBI-750487, EBI-349968;
CC Q8WW24; O75478: TADA2A; NbExp=3; IntAct=EBI-750487, EBI-742268;
CC Q8WW24; Q969V4: TEKT1; NbExp=3; IntAct=EBI-750487, EBI-10180409;
CC Q8WW24; Q01664: TFAP4; NbExp=3; IntAct=EBI-750487, EBI-2514218;
CC Q8WW24; Q96NM4-3: TOX2; NbExp=3; IntAct=EBI-750487, EBI-12815137;
CC Q8WW24; Q96RU7: TRIB3; NbExp=5; IntAct=EBI-750487, EBI-492476;
CC Q8WW24; Q15654: TRIP6; NbExp=4; IntAct=EBI-750487, EBI-742327;
CC Q8WW24; O14817: TSPAN4; NbExp=3; IntAct=EBI-750487, EBI-8652667;
CC Q8WW24; P57075-2: UBASH3A; NbExp=3; IntAct=EBI-750487, EBI-7353612;
CC Q8WW24; O75604: USP2; NbExp=3; IntAct=EBI-750487, EBI-743272;
CC Q8WW24; Q99990: VGLL1; NbExp=3; IntAct=EBI-750487, EBI-11983165;
CC Q8WW24; Q8TF47: ZFP90; NbExp=3; IntAct=EBI-750487, EBI-11419867;
CC Q8WW24; Q9NZV7: ZIM2; NbExp=3; IntAct=EBI-750487, EBI-11962760;
CC Q8WW24; Q9H0C1: ZMYND12; NbExp=3; IntAct=EBI-750487, EBI-12030590;
CC Q8WW24; P17024: ZNF20; NbExp=3; IntAct=EBI-750487, EBI-717634;
CC Q8WW24; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-750487, EBI-740727;
CC Q8WW24; Q9BUY5: ZNF426; NbExp=3; IntAct=EBI-750487, EBI-743265;
CC Q8WW24; Q6S9Z5: ZNF474; NbExp=3; IntAct=EBI-750487, EBI-17269964;
CC Q8WW24; Q9H707: ZNF552; NbExp=3; IntAct=EBI-750487, EBI-2555731;
CC Q8WW24; Q9P0T4: ZNF581; NbExp=3; IntAct=EBI-750487, EBI-745520;
CC Q8WW24; Q8N720: ZNF655; NbExp=3; IntAct=EBI-750487, EBI-625509;
CC Q8WW24; P0C7X2: ZNF688; NbExp=3; IntAct=EBI-750487, EBI-4395732;
CC Q8WW24; PRO_0000449633 [P0DTD1]: rep; Xeno; NbExp=3; IntAct=EBI-750487, EBI-25492395;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:Q2TA38}. Cell projection, cilium, flagellum
CC {ECO:0000250|UniProtKB:Q149S1}. Note=Found in the abaxial (convex)
CC surface of outer dense fibers in sperm flagella.
CC {ECO:0000250|UniProtKB:Q149S1}.
CC -!- TISSUE SPECIFICITY: Strongly expressed in spermatozoa. Also detected at
CC low levels in pancreas. {ECO:0000269|PubMed:17244819}.
CC -!- SIMILARITY: Belongs to the tektin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC097374; AAX88873.1; -; Genomic_DNA.
DR EMBL; BC021716; AAH21716.1; -; mRNA.
DR CCDS; CCDS2005.1; -.
DR RefSeq; NP_653306.1; NM_144705.3.
DR AlphaFoldDB; Q8WW24; -.
DR SMR; Q8WW24; -.
DR BioGRID; 127301; 120.
DR IntAct; Q8WW24; 117.
DR MINT; Q8WW24; -.
DR STRING; 9606.ENSP00000295201; -.
DR iPTMnet; Q8WW24; -.
DR PhosphoSitePlus; Q8WW24; -.
DR BioMuta; TEKT4; -.
DR DMDM; 74730916; -.
DR MassIVE; Q8WW24; -.
DR PaxDb; Q8WW24; -.
DR PeptideAtlas; Q8WW24; -.
DR PRIDE; Q8WW24; -.
DR ProteomicsDB; 74851; -.
DR Antibodypedia; 32286; 176 antibodies from 22 providers.
DR DNASU; 150483; -.
DR Ensembl; ENST00000295201.5; ENSP00000295201.4; ENSG00000163060.8.
DR GeneID; 150483; -.
DR KEGG; hsa:150483; -.
DR MANE-Select; ENST00000295201.5; ENSP00000295201.4; NM_144705.4; NP_653306.1.
DR UCSC; uc002stw.3; human.
DR CTD; 150483; -.
DR DisGeNET; 150483; -.
DR GeneCards; TEKT4; -.
DR HGNC; HGNC:31012; TEKT4.
DR HPA; ENSG00000163060; Tissue enriched (testis).
DR neXtProt; NX_Q8WW24; -.
DR OpenTargets; ENSG00000163060; -.
DR PharmGKB; PA142670819; -.
DR VEuPathDB; HostDB:ENSG00000163060; -.
DR eggNOG; KOG2685; Eukaryota.
DR GeneTree; ENSGT00950000182894; -.
DR HOGENOM; CLU_033588_2_1_1; -.
DR InParanoid; Q8WW24; -.
DR OMA; RNLEDTH; -.
DR OrthoDB; 581072at2759; -.
DR PhylomeDB; Q8WW24; -.
DR TreeFam; TF320754; -.
DR PathwayCommons; Q8WW24; -.
DR SignaLink; Q8WW24; -.
DR BioGRID-ORCS; 150483; 33 hits in 1067 CRISPR screens.
DR GenomeRNAi; 150483; -.
DR Pharos; Q8WW24; Tbio.
DR PRO; PR:Q8WW24; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q8WW24; protein.
DR Bgee; ENSG00000163060; Expressed in right uterine tube and 84 other tissues.
DR ExpressionAtlas; Q8WW24; baseline and differential.
DR GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR GO; GO:0015630; C:microtubule cytoskeleton; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR GO; GO:0036126; C:sperm flagellum; IBA:GO_Central.
DR GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR GO; GO:0060294; P:cilium movement involved in cell motility; IBA:GO_Central.
DR InterPro; IPR000435; Tektin.
DR PANTHER; PTHR19960; PTHR19960; 1.
DR PRINTS; PR00511; TEKTIN.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Cilium biogenesis/degradation; Coiled coil;
KW Cytoplasm; Cytoskeleton; Flagellum; Reference proteome.
FT CHAIN 1..435
FT /note="Tektin-4"
FT /id="PRO_0000261161"
FT REGION 60..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 102..180
FT /evidence="ECO:0000255"
FT COILED 310..336
FT /evidence="ECO:0000255"
FT COILED 363..411
FT /evidence="ECO:0000255"
FT COMPBIAS 71..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 83
FT /note="T -> M (in dbSNP:rs4854235)"
FT /id="VAR_029085"
FT VARIANT 100
FT /note="S -> G (in dbSNP:rs11164112)"
FT /id="VAR_062151"
FT VARIANT 102
FT /note="K -> N (in dbSNP:rs17802433)"
FT /id="VAR_029086"
FT VARIANT 272
FT /note="C -> S (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035941"
FT VARIANT 409
FT /note="N -> K (in dbSNP:rs17120062)"
FT /id="VAR_029087"
SQ SEQUENCE 435 AA; 50649 MW; 90C16D8B0F782CED CRC64;
MAQTVPPCEL PCKEYDVARN TGAYTSSGLA TASFRTSKYL LEEWFQNCYA RYHQAFADRD
QSERQRHESQ QLATETQALA QRTQQDSTRT VGERLQDTHS WKSELQREME ALAAETNLLL
AQKQRLERAL DATEVPFSIT TDNLQCRERR EHPNLVRDHV ETELLKEAEL IRNIQELLKR
TIMQAVSQIR LNREHKETCE MDWSDKMEAY NIDETCGRHH SQSTEVQAHP YSTTFQESAS
TPETRAKFTQ DNLCRAQRER LASANLRVLV DCILRDTSED LRLQCDAVNL AFGRRCEELE
DARYKLHHHL HKTLREITDQ EHNVAALKQA IKDKEAPLHV AQTRLYLRSH RPNMELCRDA
AQFRLLSEVE ELNMSLTALR EKLLEAEQSL RNLEDIHMSL EKDIAAMTNS LFIDRQKCMA
HRTRYPTILQ LAGYQ
