ID   TEKT4_RAT               Reviewed;         447 AA.
AC   Q6AXV2;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Tektin-4;
GN   Name=Tekt4; Synonyms=Tek4;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND SUBCELLULAR LOCATION.
RC   STRAIN=Wistar; TISSUE=Testis;
RX   PubMed=16596631; DOI=10.1002/mrd.20486;
RA   Iida H., Honda Y., Matsuyama T., Shibata Y., Inai T.;
RT   "Tektin 4 is located on outer dense fibers, not associated with axonemal
RT   tubulins of flagella in rodent spermatozoa.";
RL   Mol. Reprod. Dev. 73:929-936(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC       doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms
CC       filamentous polymers in the walls of ciliary and flagellar microtubules
CC       (By similarity). Contributes to normal sperm motility (By similarity).
CC       {ECO:0000250|UniProtKB:Q2TA38, ECO:0000250|UniProtKB:Q6X6Z7}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:Q2TA38}. Cell projection, cilium, flagellum
CC       {ECO:0000250|UniProtKB:Q149S1}. Note=Found in the abaxial (convex)
CC       surface of outer dense fibers in sperm flagella.
CC       {ECO:0000250|UniProtKB:Q149S1}.
CC   -!- SIMILARITY: Belongs to the tektin family. {ECO:0000305}.
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DR   EMBL; AB194013; BAD93477.1; -; mRNA.
DR   EMBL; BC079304; AAH79304.1; -; mRNA.
DR   RefSeq; NP_001013987.1; NM_001013965.1.
DR   AlphaFoldDB; Q6AXV2; -.
DR   SMR; Q6AXV2; -.
DR   STRING; 10116.ENSRNOP00000025434; -.
DR   PaxDb; Q6AXV2; -.
DR   PRIDE; Q6AXV2; -.
DR   Ensembl; ENSRNOT00000025434; ENSRNOP00000025434; ENSRNOG00000018792.
DR   GeneID; 302991; -.
DR   KEGG; rno:302991; -.
DR   UCSC; RGD:1308075; rat.
DR   CTD; 150483; -.
DR   RGD; 1308075; Tekt4.
DR   eggNOG; KOG2685; Eukaryota.
DR   GeneTree; ENSGT00950000182894; -.
DR   HOGENOM; CLU_033588_2_1_1; -.
DR   InParanoid; Q6AXV2; -.
DR   OMA; RNLEDTH; -.
DR   OrthoDB; 581072at2759; -.
DR   PhylomeDB; Q6AXV2; -.
DR   TreeFam; TF320754; -.
DR   PRO; PR:Q6AXV2; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000018792; Expressed in testis and 6 other tissues.
DR   Genevisible; Q6AXV2; RN.
DR   GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR   GO; GO:0015630; C:microtubule cytoskeleton; IBA:GO_Central.
DR   GO; GO:0036126; C:sperm flagellum; ISO:RGD.
DR   GO; GO:0097225; C:sperm midpiece; ISO:RGD.
DR   GO; GO:0097228; C:sperm principal piece; ISO:RGD.
DR   GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR   GO; GO:0060294; P:cilium movement involved in cell motility; ISO:RGD.
DR   GO; GO:0060378; P:regulation of brood size; ISO:RGD.
DR   InterPro; IPR000435; Tektin.
DR   PANTHER; PTHR19960; PTHR19960; 1.
DR   PRINTS; PR00511; TEKTIN.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Coiled coil;
KW   Cytoplasm; Cytoskeleton; Flagellum; Reference proteome.
FT   CHAIN           1..447
FT                   /note="Tektin-4"
FT                   /id="PRO_0000261164"
FT   COILED          114..143
FT                   /evidence="ECO:0000255"
FT   COILED          324..348
FT                   /evidence="ECO:0000255"
FT   COILED          375..423
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   447 AA;  52148 MW;  C8CFF78148F22E98 CRC64;
     MAQAEVLLTK EPAPQSIDVC ELPQKKYEVA CNTGAYTSAG LATAGFRTAK YLMDEWFQNS
     YARYHQAFAD RDYSERQRHE SKQLAAETGE LAYRTQLDST RRVGERLEDM HCWKSELQRE
     IDELSSETDQ MMAQKLRLQR ALDALSVPFS IATDNLQCRE RRQHPDLVRD YVEVELLKET
     ELIRNIQELL KRTMGQAVGQ IRLNREHKEN CEINWSDKVE VYNIDDTCAR YTNESTQVQF
     YPHSSKFEES ASTPETWGKF TQDVLLRAER ERLASVNLRK LIDCILRDTA EDLRLQCDAV
     NLAFSNRCEE LNDARQKLQY HLLKILSEIT DQEHQIAALK QAIKDKEAPL RVAQTRLYQR
     SHRPNVELCR DNAQFRLMSE VEELNMSLKV LKEKLQDAEQ ALRNLEDSRM SLEKDIAVKT
     NSLFIDRQKC MTHRNRYPSV LQLAGYQ