TEKT5_HUMAN
ID TEKT5_HUMAN Reviewed; 485 AA.
AC Q96M29; A1L3Z3;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Tektin-5;
GN Name=TEKT5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be a structural component of the sperm flagellum.
CC {ECO:0000250|UniProtKB:G5E8A8}.
CC -!- INTERACTION:
CC Q96M29; Q9ULX6: AKAP8L; NbExp=3; IntAct=EBI-10239812, EBI-357530;
CC Q96M29; O95429: BAG4; NbExp=3; IntAct=EBI-10239812, EBI-2949658;
CC Q96M29; Q5BKX5-3: C19orf54; NbExp=3; IntAct=EBI-10239812, EBI-11976299;
CC Q96M29; Q8N865: C7orf31; NbExp=3; IntAct=EBI-10239812, EBI-10174456;
CC Q96M29; Q9NPB3: CABP2; NbExp=3; IntAct=EBI-10239812, EBI-12011224;
CC Q96M29; A8MUP2: CSKMT; NbExp=3; IntAct=EBI-10239812, EBI-12842046;
CC Q96M29; Q86UW9: DTX2; NbExp=3; IntAct=EBI-10239812, EBI-740376;
CC Q96M29; O15197-2: EPHB6; NbExp=3; IntAct=EBI-10239812, EBI-10182490;
CC Q96M29; O00167-2: EYA2; NbExp=3; IntAct=EBI-10239812, EBI-12807776;
CC Q96M29; Q53EP0-3: FNDC3B; NbExp=3; IntAct=EBI-10239812, EBI-10242151;
CC Q96M29; O75593: FOXH1; NbExp=3; IntAct=EBI-10239812, EBI-1759806;
CC Q96M29; Q12951-2: FOXI1; NbExp=3; IntAct=EBI-10239812, EBI-12018822;
CC Q96M29; O14964: HGS; NbExp=3; IntAct=EBI-10239812, EBI-740220;
CC Q96M29; P49639: HOXA1; NbExp=3; IntAct=EBI-10239812, EBI-740785;
CC Q96M29; P17509: HOXB6; NbExp=3; IntAct=EBI-10239812, EBI-741308;
CC Q96M29; Q2WGJ6: KLHL38; NbExp=3; IntAct=EBI-10239812, EBI-6426443;
CC Q96M29; P60329: KRTAP12-4; NbExp=3; IntAct=EBI-10239812, EBI-10176396;
CC Q96M29; Q3LI76: KRTAP15-1; NbExp=3; IntAct=EBI-10239812, EBI-11992140;
CC Q96M29; Q3LI70: KRTAP19-6; NbExp=3; IntAct=EBI-10239812, EBI-12805508;
CC Q96M29; Q3SYF9: KRTAP19-7; NbExp=3; IntAct=EBI-10239812, EBI-10241353;
CC Q96M29; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-10239812, EBI-11962084;
CC Q96M29; Q14847-2: LASP1; NbExp=3; IntAct=EBI-10239812, EBI-9088686;
CC Q96M29; O60336: MAPKBP1; NbExp=3; IntAct=EBI-10239812, EBI-947402;
CC Q96M29; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-10239812, EBI-10271199;
CC Q96M29; Q8NBF2-2: NHLRC2; NbExp=3; IntAct=EBI-10239812, EBI-10697320;
CC Q96M29; P78337: PITX1; NbExp=5; IntAct=EBI-10239812, EBI-748265;
CC Q96M29; Q9NRQ2: PLSCR4; NbExp=3; IntAct=EBI-10239812, EBI-769257;
CC Q96M29; O75360: PROP1; NbExp=3; IntAct=EBI-10239812, EBI-9027467;
CC Q96M29; P28070: PSMB4; NbExp=3; IntAct=EBI-10239812, EBI-603350;
CC Q96M29; Q2TAL8: QRICH1; NbExp=3; IntAct=EBI-10239812, EBI-2798044;
CC Q96M29; Q93062-3: RBPMS; NbExp=3; IntAct=EBI-10239812, EBI-740343;
CC Q96M29; Q92753-1: RORB; NbExp=3; IntAct=EBI-10239812, EBI-18560266;
CC Q96M29; Q01196-8: RUNX1; NbExp=3; IntAct=EBI-10239812, EBI-12001422;
CC Q96M29; Q53HV7-2: SMUG1; NbExp=3; IntAct=EBI-10239812, EBI-12275818;
CC Q96M29; Q99932-2: SPAG8; NbExp=3; IntAct=EBI-10239812, EBI-11959123;
CC Q96M29; Q96SF7: TBX15; NbExp=3; IntAct=EBI-10239812, EBI-10191361;
CC Q96M29; O43711: TLX3; NbExp=3; IntAct=EBI-10239812, EBI-3939165;
CC Q96M29; Q63HR2: TNS2; NbExp=6; IntAct=EBI-10239812, EBI-949753;
CC Q96M29; Q96NM4-3: TOX2; NbExp=3; IntAct=EBI-10239812, EBI-12815137;
CC Q96M29; Q70EL1-9: USP54; NbExp=3; IntAct=EBI-10239812, EBI-11975223;
CC Q96M29; O95231: VENTX; NbExp=3; IntAct=EBI-10239812, EBI-10191303;
CC Q96M29; Q9H0C1: ZMYND12; NbExp=5; IntAct=EBI-10239812, EBI-12030590;
CC Q96M29; P36508: ZNF76; NbExp=3; IntAct=EBI-10239812, EBI-7254550;
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000250|UniProtKB:G5E8A8}. Note=Appears to be associated with
CC flagellar accessory structures and not the axoneme.
CC {ECO:0000250|UniProtKB:G5E8A8}.
CC -!- SIMILARITY: Belongs to the tektin family. {ECO:0000305}.
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DR EMBL; AK057433; BAB71484.1; -; mRNA.
DR EMBL; BC130336; AAI30337.1; -; mRNA.
DR EMBL; BC130338; AAI30339.1; -; mRNA.
DR CCDS; CCDS10542.1; -.
DR RefSeq; NP_653275.1; NM_144674.1.
DR AlphaFoldDB; Q96M29; -.
DR SMR; Q96M29; -.
DR BioGRID; 126976; 50.
DR IntAct; Q96M29; 46.
DR STRING; 9606.ENSP00000283025; -.
DR iPTMnet; Q96M29; -.
DR PhosphoSitePlus; Q96M29; -.
DR BioMuta; TEKT5; -.
DR DMDM; 74732290; -.
DR MassIVE; Q96M29; -.
DR PaxDb; Q96M29; -.
DR PeptideAtlas; Q96M29; -.
DR PRIDE; Q96M29; -.
DR ProteomicsDB; 77289; -.
DR Antibodypedia; 52193; 174 antibodies from 25 providers.
DR DNASU; 146279; -.
DR Ensembl; ENST00000283025.7; ENSP00000283025.2; ENSG00000153060.8.
DR GeneID; 146279; -.
DR KEGG; hsa:146279; -.
DR MANE-Select; ENST00000283025.7; ENSP00000283025.2; NM_144674.2; NP_653275.1.
DR UCSC; uc002czz.2; human.
DR CTD; 146279; -.
DR DisGeNET; 146279; -.
DR GeneCards; TEKT5; -.
DR HGNC; HGNC:26554; TEKT5.
DR HPA; ENSG00000153060; Tissue enriched (testis).
DR MIM; 618686; gene.
DR neXtProt; NX_Q96M29; -.
DR OpenTargets; ENSG00000153060; -.
DR PharmGKB; PA162405603; -.
DR VEuPathDB; HostDB:ENSG00000153060; -.
DR eggNOG; KOG2685; Eukaryota.
DR GeneTree; ENSGT00950000182894; -.
DR HOGENOM; CLU_033588_2_1_1; -.
DR InParanoid; Q96M29; -.
DR OMA; HDWDQSN; -.
DR OrthoDB; 581072at2759; -.
DR PhylomeDB; Q96M29; -.
DR TreeFam; TF320754; -.
DR PathwayCommons; Q96M29; -.
DR SignaLink; Q96M29; -.
DR BioGRID-ORCS; 146279; 6 hits in 1067 CRISPR screens.
DR ChiTaRS; TEKT5; human.
DR GenomeRNAi; 146279; -.
DR Pharos; Q96M29; Tbio.
DR PRO; PR:Q96M29; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q96M29; protein.
DR Bgee; ENSG00000153060; Expressed in left testis and 104 other tissues.
DR ExpressionAtlas; Q96M29; baseline and differential.
DR Genevisible; Q96M29; HS.
DR GO; GO:0015630; C:microtubule cytoskeleton; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR GO; GO:0036126; C:sperm flagellum; IBA:GO_Central.
DR GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR GO; GO:0060294; P:cilium movement involved in cell motility; IBA:GO_Central.
DR InterPro; IPR000435; Tektin.
DR PANTHER; PTHR19960; PTHR19960; 1.
DR PRINTS; PR00511; TEKTIN.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Coiled coil; Flagellum; Reference proteome.
FT CHAIN 1..485
FT /note="Tektin-5"
FT /id="PRO_0000261171"
FT COILED 114..185
FT /evidence="ECO:0000255"
FT COILED 225..247
FT /evidence="ECO:0000255"
FT COILED 307..385
FT /evidence="ECO:0000255"
FT COILED 421..444
FT /evidence="ECO:0000255"
FT VARIANT 59
FT /note="A -> T (in dbSNP:rs16957557)"
FT /id="VAR_053722"
FT VARIANT 196
FT /note="H -> R (in dbSNP:rs16957546)"
FT /id="VAR_053723"
FT VARIANT 239
FT /note="M -> T (in dbSNP:rs17684500)"
FT /id="VAR_053724"
FT VARIANT 315
FT /note="Q -> R (in dbSNP:rs2719710)"
FT /id="VAR_053725"
SQ SEQUENCE 485 AA; 56294 MW; 615A98D46699B876 CRC64;
MEFLGTTQTA SYCGPKKCCG LTSLPAVQAP VIQECYQPYY LPGYRYLNSW RPSLFYKIAN
VQTCPDESTS TLRPPTILPT LRSALFSRYS PHDWDQSNQL QVRGAEASRL WASRLTDDSM
RLLQDKDQLT HQMQEGTCRN LGQRLSDIGF WKSELSYELD RLLTENQNLE TVKRRLECAA
NEVNCPLQVA LECLYHREKR IGIDLVHDNV EKNLIREVDL LKCCQEQMRK LAQRIDIQMR
DNRDAQHVLE RDLEDKSSAQ CIDEKCFNLR NTSDCISFFH GMEKIDGTIS VPETWAKFSN
DNIKHSQNMR ANSIQLREEA EHLFETLSDQ MWRQFTDTNL AFNARISEVT DVKNKLQTQL
AKTLQEIFQA ENTIMLLERS IMAKEGPLKV AQTRLECRTR RPNMELCRDI PQLKLVNEVF
TIDDTLQTLK LRLRETQDTL QLLVMTKCRL EHELAIKANT LCIDKEKCMG MRKTFPCTPR
LVGHT
