TEKT5_MOUSE
ID TEKT5_MOUSE Reviewed; 557 AA.
AC G5E8A8; D5HP88; Q14BE9;
DT 08-JUN-2016, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Tektin-5 {ECO:0000303|PubMed:20378928};
GN Name=Tekt5 {ECO:0000303|PubMed:20378928};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|Proteomes:UP000000589};
RN [1] {ECO:0000312|EMBL:ADD80740.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, DEVELOPMENTAL STAGE, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=CD-1 {ECO:0000312|EMBL:ADD80740.1};
RX PubMed=20378928; DOI=10.2164/jandrol.109.009456;
RA Cao W., Ijiri T.W., Huang A.P., Gerton G.L.;
RT "Characterization of a novel tektin member, TEKT5, in mouse sperm.";
RL J. Androl. 32:55-69(2011).
RN [2] {ECO:0000312|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000312|EMBL:EDK97311.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000312|EMBL:AAI15970.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAI15970.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be a structural component of the sperm flagellum.
CC {ECO:0000305|PubMed:20378928}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000269|PubMed:20378928}. Note=Appears to be associated with
CC flagellar accessory structures and not the axoneme.
CC {ECO:0000269|PubMed:20378928}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=G5E8A8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=G5E8A8-2; Sequence=VSP_058377;
CC -!- TISSUE SPECIFICITY: Strongly expressed in germ cells of the testis (at
CC protein level). Also detected in brain. {ECO:0000269|PubMed:20378928}.
CC -!- DEVELOPMENTAL STAGE: In germ cells, has highest expression levels
CC during late spermiogenesis (in round spermatids and condensing
CC spermatids). {ECO:0000269|PubMed:20378928}.
CC -!- SIMILARITY: Belongs to the tektin family. {ECO:0000305}.
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DR EMBL; GQ292766; ADD80740.1; -; mRNA.
DR EMBL; AC154311; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466521; EDK97311.1; -; Genomic_DNA.
DR EMBL; BC115969; AAI15970.1; -; mRNA.
DR CCDS; CCDS70683.1; -. [G5E8A8-1]
DR RefSeq; NP_001092745.1; NM_001099275.1.
DR RefSeq; NP_001277930.1; NM_001291001.1. [G5E8A8-1]
DR AlphaFoldDB; G5E8A8; -.
DR SMR; G5E8A8; -.
DR IntAct; G5E8A8; 1.
DR MINT; G5E8A8; -.
DR STRING; 10090.ENSMUSP00000111497; -.
DR PhosphoSitePlus; G5E8A8; -.
DR PaxDb; G5E8A8; -.
DR PRIDE; G5E8A8; -.
DR ProteomicsDB; 263162; -. [G5E8A8-1]
DR ProteomicsDB; 263163; -. [G5E8A8-2]
DR Antibodypedia; 52193; 174 antibodies from 25 providers.
DR DNASU; 70426; -.
DR Ensembl; ENSMUST00000043415; ENSMUSP00000046824; ENSMUSG00000039179. [G5E8A8-1]
DR Ensembl; ENSMUST00000115831; ENSMUSP00000111497; ENSMUSG00000039179. [G5E8A8-2]
DR GeneID; 70426; -.
DR KEGG; mmu:70426; -.
DR UCSC; uc007ydl.3; mouse. [G5E8A8-1]
DR UCSC; uc007ydm.3; mouse.
DR CTD; 146279; -.
DR MGI; MGI:1917676; Tekt5.
DR VEuPathDB; HostDB:ENSMUSG00000039179; -.
DR eggNOG; KOG2685; Eukaryota.
DR GeneTree; ENSGT00950000182894; -.
DR HOGENOM; CLU_033588_2_0_1; -.
DR InParanoid; G5E8A8; -.
DR OMA; HDWDQSN; -.
DR OrthoDB; 581072at2759; -.
DR PhylomeDB; G5E8A8; -.
DR TreeFam; TF320754; -.
DR BioGRID-ORCS; 70426; 2 hits in 75 CRISPR screens.
DR ChiTaRS; Tekt5; mouse.
DR PRO; PR:G5E8A8; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; G5E8A8; protein.
DR Bgee; ENSMUSG00000039179; Expressed in seminiferous tubule of testis and 40 other tissues.
DR GO; GO:0015630; C:microtubule cytoskeleton; IBA:GO_Central.
DR GO; GO:0036126; C:sperm flagellum; IDA:UniProtKB.
DR GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR GO; GO:0060294; P:cilium movement involved in cell motility; IBA:GO_Central.
DR InterPro; IPR000435; Tektin.
DR PANTHER; PTHR19960; PTHR19960; 1.
DR PRINTS; PR00511; TEKTIN.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell projection; Cilium; Coiled coil; Flagellum;
KW Reference proteome; Repeat.
FT CHAIN 1..557
FT /note="Tektin-5"
FT /id="PRO_0000436475"
FT REPEAT 507..512
FT /note="1"
FT /evidence="ECO:0000305"
FT REPEAT 513..518
FT /note="2"
FT /evidence="ECO:0000305"
FT REPEAT 519..524
FT /note="3"
FT /evidence="ECO:0000305"
FT REPEAT 525..530
FT /note="4"
FT /evidence="ECO:0000305"
FT REPEAT 531..536
FT /note="5"
FT /evidence="ECO:0000305"
FT REPEAT 537..541
FT /note="6"
FT /evidence="ECO:0000305"
FT REGION 507..541
FT /note="6 X 6 AA approximate tandem repeats of C-[GSK]-G-
FT [GSPH]-A-[SLP]"
FT /evidence="ECO:0000305"
FT COILED 302..386
FT /evidence="ECO:0000255"
FT VAR_SEQ 416..557
FT /note="Missing (in isoform 2)"
FT /id="VSP_058377"
SQ SEQUENCE 557 AA; 62734 MW; 90AB6782207FB7B6 CRC64;
MEFLGTTQTA SFCGPKKGCG LQALPPAGQE PVVQECYQPF HLPGYRYLNA WRPSVFHKIA
TSQTIPEECS GIRRPPTILP SLRSALFCRY TPRDWDRSND LQIRNAEASR LWASRLTGDS
LRIMQDKDQL IHQMQEGTSR NLGQRLSDLG FWKSELCYEL DRLLTENSSM DTLKRRLECA
AEEVNCPLQV ALECLYNREK RIGIDLVHDN VEKNLIREVD LLKCCQDQMR KLAKRIDFQI
RDNRDAQHSL ERDIEDKSSA QYIDENCFNL RSTSDSISFF HGVEKFDGTV SIPETWAKFS
NDNIRHAQNM RANSIRLREE AEHLFETLSD QMWKQFTNTN LAFNARISEE TDVKNKLQTQ
LAKILQEIFQ AENTIMLLER AIVAKEYPLK MAQTMLACRT RRPNVELCRD VPQFRLVNEV
FTIDDTLQTL KLRLRETQDT LQLLVMTKSR LEHELAIKAN TLCIDKDKCM SMRKSFPSTP
RLTGYTCSAI GSGPYANHAP RISSGPCSGS ALCKGPASCG GGASCGGGAS CGGHAPCGSA
LCSHSVSRSG PGFAPVC
