ID   TELL_STAA8              Reviewed;         378 AA.
AC   Q2FYM7;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=TelA-like protein SAOUHSC_01408;
GN   OrderedLocusNames=SAOUHSC_01408;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
RN   [2]
RP   MUTANT STUDIES.
RX   PubMed=16923874; DOI=10.1128/jb.00551-06;
RA   Shaw L.N., Aish J., Davenport J.E., Brown M.C., Lithgow J.K., Simmonite K.,
RA   Crossley H., Travis J., Potempa J., Foster S.J.;
RT   "Investigations into sigmaB-modulated regulatory pathways governing
RT   extracellular virulence determinant production in Staphylococcus aureus.";
RL   J. Bacteriol. 188:6070-6080(2006).
CC   -!- MISCELLANEOUS: Disruption of this gene leads to an increase in hla
CC       (alpha-hemolysin) transcription and proteases production.
CC   -!- SIMILARITY: Belongs to the TelA family. {ECO:0000305}.
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DR   EMBL; CP000253; ABD30502.1; -; Genomic_DNA.
DR   RefSeq; WP_000138413.1; NZ_LS483365.1.
DR   RefSeq; YP_499935.1; NC_007795.1.
DR   AlphaFoldDB; Q2FYM7; -.
DR   SMR; Q2FYM7; -.
DR   STRING; 1280.SAXN108_1423; -.
DR   EnsemblBacteria; ABD30502; ABD30502; SAOUHSC_01408.
DR   GeneID; 3920640; -.
DR   KEGG; sao:SAOUHSC_01408; -.
DR   PATRIC; fig|93061.5.peg.1288; -.
DR   eggNOG; COG3853; Bacteria.
DR   HOGENOM; CLU_032111_0_0_9; -.
DR   OMA; LDKRVHD; -.
DR   PRO; PR:Q2FYM7; -.
DR   Proteomes; UP000008816; Chromosome.
DR   InterPro; IPR008863; Toxic_anion-R_TelA.
DR   PANTHER; PTHR38432; PTHR38432; 1.
DR   Pfam; PF05816; TelA; 1.
DR   PIRSF; PIRSF026508; TelA; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..378
FT                   /note="TelA-like protein SAOUHSC_01408"
FT                   /id="PRO_0000281403"
SQ   SEQUENCE   378 AA;  43407 MW;  141ECCAD46370180 CRC64;
     MTENKSFKES HPLDDFISDK ELSNTTIQKE KLTIEQQKQV DTISKQINPL DNEGLLAFGS
     DLQKQMSQFS HQMLDEVQSK DVGPIGDTLS DLMSKLKSVN PNELNTDKPS MLKRIFSRAK
     SSINEIFSRM QSVSAQVDRI TIQLQKHQTH LTRDIELLDT LYDKNKQYFD DLSLHIIAAQ
     QKKLQLENEK LPQLQQQAQQ STNQMDIQQV ADMQQFIDRL DKRIYDLQLS RQIALQTAPQ
     IRMIQNVNQA LAEKIQSSIL TSIPLWKNQM AIALTLMRQR NAVAAQRAVT DTTNDLLTAN
     AEMLKQNAIE TATENERGIV DLDTLKRTQR NIIETIEETL IIQQHGREER QLAEKELQQL
     EQDLKSHLVN IKGPNKQS