ID   TELO2_XENLA             Reviewed;         835 AA.
AC   Q6GPP1;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 2.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Telomere length regulation protein TEL2 homolog;
GN   Name=telo2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of the DNA damage response (DDR). Part of the TTT
CC       complex that is required to stabilize protein levels of the
CC       phosphatidylinositol 3-kinase-related protein kinase (PIKK) family
CC       proteins. Promotes assembly, stabilizes and maintains the activity of
CC       TORC complexes, which regulate cell growth and survival in response to
CC       nutrient and hormonal signals. May be involved in telomere length
CC       regulation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}.
CC       Nucleus {ECO:0000250}. Chromosome, telomere {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TEL2 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH73072.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC073072; AAH73072.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; Q6GPP1; -.
DR   SMR; Q6GPP1; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.25.40.720; -; 2.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR038528; TEL2_C_sf.
DR   InterPro; IPR019337; Telomere_length_regulation_dom.
DR   Pfam; PF10193; Telomere_reg-2; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; Cytoplasm; Membrane; Nucleus; Reference proteome; Telomere.
FT   CHAIN           1..835
FT                   /note="Telomere length regulation protein TEL2 homolog"
FT                   /id="PRO_0000318518"
FT   REGION          455..501
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          629..648
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        474..489
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   835 AA;  93679 MW;  338BA833A3BD4BDF CRC64;
     MDASQADRKV APVSAVVKNA ICELSRINDG ERLMEVLLSL KCYLGTRENS TQTQEHAEFN
     RNHYTPFLEF LVAQMGPQWL DLLTLEKLEL WDSFFLEGPA DQAFLVLMDS LGKTGPSIRL
     DRCVHVLERF LQRGALAEVI REVCQQQLES NPTAVLHEAI LGRISSLPDH LANCLQQHNK
     PVFYPNNYYP LLAGSIISVL QMVSDALRDG KNCSISFASQ VVGKVCMQGR QKELLSVLVP
     RLKSLVQSDC IWQRICWRLV ESVPDRWMEP VVIGIVQMAP GAEFLSQLLG DLVVKNKRTQ
     FLLTKKMLFL QYGLKKDALQ SILGYLSLDA SRRYLLVKIL RELLEVWSSG SVLKNSSQPQ
     LLHVSRCLLI CLGLLNKQEI ESCKQDLLVS LTSGARNYLD SSVPAIRRMG MVVAECLSHR
     IDTEGPGLSF QYEEDEDTRD LKALLKPPHV FEADSADCVK NPEESSPSKS CPKAIEKSKM
     EAKADQASDS ELDSDDDLAP YDMSADTELK KSKAPAYIRD CIEVLLSDDV EKLEVTMTCL
     ATLIQANTSA TKEVSVELTK ILLHIDDKPS VERFTELRHA ALVAVAVTDP VPVSQYLTGE
     FYSLNYSLRQ RMDILDVLSS AAQSLSEKLS HEVSSESRST GTGQHSIRST TWTLAEAPAD
     WRKVVEERIA SKTRRFSKGQ SVPTPVPAPN RYHAVAGHLF FPLIQNYDRQ IVTFDLLGED
     RLVLGRMVHT LGILMHLALH APIASQMGKA LLEFVWVLRF HIDAFVRQGL LFCISTVLLS
     VPWERLMTDM AEEVMETQSW LADVAERDSD DDCRRLALNG LFLMEKLRNN IHGTP