ID   TELO2_XENTR             Reviewed;         829 AA.
AC   Q08CY4; A4IGR3;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Telomere length regulation protein TEL2 homolog;
GN   Name=telo2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=N6; TISSUE=Oviduct;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of the DNA damage response (DDR). Part of the TTT
CC       complex that is required to stabilize protein levels of the
CC       phosphatidylinositol 3-kinase-related protein kinase (PIKK) family
CC       proteins. Promotes assembly, stabilizes and maintains the activity of
CC       TORC complexes, which regulate cell growth and survival in response to
CC       nutrient and hormonal signals. May be involved in telomere length
CC       regulation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}.
CC       Nucleus {ECO:0000250}. Chromosome, telomere {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q08CY4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q08CY4-2; Sequence=VSP_031210;
CC   -!- SIMILARITY: Belongs to the TEL2 family. {ECO:0000305}.
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DR   EMBL; BC124033; AAI24034.1; -; mRNA.
DR   EMBL; BC135213; AAI35214.1; -; mRNA.
DR   RefSeq; NP_001072876.1; NM_001079408.1. [Q08CY4-1]
DR   AlphaFoldDB; Q08CY4; -.
DR   SMR; Q08CY4; -.
DR   STRING; 8364.ENSXETP00000022773; -.
DR   PaxDb; Q08CY4; -.
DR   PRIDE; Q08CY4; -.
DR   DNASU; 780338; -.
DR   GeneID; 780338; -.
DR   KEGG; xtr:780338; -.
DR   CTD; 9894; -.
DR   Xenbase; XB-GENE-1010705; telo2.
DR   eggNOG; KOG4346; Eukaryota.
DR   HOGENOM; CLU_008764_1_0_1; -.
DR   InParanoid; Q08CY4; -.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0070209; C:ASTRA complex; IBA:GO_Central.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051879; F:Hsp90 protein binding; IBA:GO_Central.
DR   GO; GO:0042162; F:telomeric DNA binding; IBA:GO_Central.
DR   GO; GO:0050821; P:protein stabilization; IBA:GO_Central.
DR   GO; GO:0007004; P:telomere maintenance via telomerase; IBA:GO_Central.
DR   Gene3D; 1.25.40.720; -; 2.
DR   InterPro; IPR038528; TEL2_C_sf.
DR   InterPro; IPR019337; Telomere_length_regulation_dom.
DR   Pfam; PF10193; Telomere_reg-2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Chromosome; Cytoplasm; Membrane; Nucleus;
KW   Reference proteome; Telomere.
FT   CHAIN           1..829
FT                   /note="Telomere length regulation protein TEL2 homolog"
FT                   /id="PRO_0000318519"
FT   REGION          446..493
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          620..641
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        466..483
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         474..478
FT                   /note="VKVKA -> V (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_031210"
FT   CONFLICT        634
FT                   /note="V -> I (in Ref. 1; AAI35214)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   829 AA;  92822 MW;  A97884D66516DCB8 CRC64;
     MAPVSTVVKN AISDLAKISD GERLREALLS LKSYLGTGEN SAQTQETTEF NRNHYTPVLE
     FLVAQIGPQW LDLLTSERLE LWDSFFLEGP PDQAFLVLMD SLGKTGPSIR LDRCVHVLER
     FLQRGALAEV IWEVCQQQLE SNPTSVLHEA ILGRISSLPD HLANCLQQHN KPLFYPKNYY
     PRLAGSIIRV LQMVSDALRD GKNCSISFAS QVVGKVCMQG RQKELLSVLV PRLKSLVQSD
     CIWQRICWRL LESVPDRWME PVLTGIVQTA PGAEVLSQLL GDLVVKNKRT QFLLTKKMLF
     LQYGLKKDAL QSILGYLSLD ASRRHLLVKV LRELLEVWSS GSVVKHSPHP QLLHVSRCLL
     ICLGLLNKQE IESCKQDLLV SLTSGARNYL DSSVPTTRRM GMVVAECLSH HIDTEGPGLS
     FQYEEDEDTR DLKALLKPPH MVETDSADFV KRPVESSPSK SPLSSPEVRE KSKVKVKADQ
     ASDSDLDSDD DLVPYDMSAD TELKKSKAPA YIRDCIEVLL SDDVEKLEVT MASLATLIQA
     NTLATKEVSM ELAKILLHID EKPSVARFTE LRHAALVAVT VTDPVTVSQY LTSEFYSLNY
     SLRQRMDILD VLSSAAQSLS EKPSHETSAE SGSVNTDPHS IRSTAWTSSE VPVNWRKVVE
     ERIASKTRRF AKGHSAATPV PAPNRYHAVA GHFFFPLIQN YDRQIVTFDL LGEDRLVLGR
     MVHTLGILMH LTLNAPIASQ MGKALLEFVW VLRSHTDAFV RQGLLFCIST VLLSVPWEHL
     MTDMAEEVVE TQCWLAEVAE RDSDDDCRRL ALNGLFLMEK LRSNIQGNP