ID   TELT_BOVIN              Reviewed;         166 AA.
AC   Q6T8D8; A5PJF8;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Telethonin;
DE   AltName: Full=Titin cap protein;
GN   Name=TCAP;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Yu S.L., Chung H.J., Jung K.C., Sang B.C., Yoon D.H., Kata S.R.,
RA   Womack J.E., Lee J.H.;
RT   "Cloning and characterization of bovine telethonin gene.";
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Muscle assembly regulating factor. Mediates the antiparallel
CC       assembly of titin (TTN) molecules at the sarcomeric Z-disk (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with MYOZ1, MYOZ2 and MYOZ3. Interacts with CSRP3.
CC       Interacts directly with the N-terminal Ig-like domains of 2 titin (TTN)
CC       molecules. Interacts with ANKRD2; the interaction is direct (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere {ECO:0000250}.
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DR   EMBL; AY428575; AAR11378.1; -; Genomic_DNA.
DR   EMBL; BC103048; AAI03049.1; -; mRNA.
DR   EMBL; BC142094; AAI42095.1; -; mRNA.
DR   RefSeq; NP_001014915.1; NM_001014915.2.
DR   AlphaFoldDB; Q6T8D8; -.
DR   SMR; Q6T8D8; -.
DR   STRING; 9913.ENSBTAP00000015579; -.
DR   PaxDb; Q6T8D8; -.
DR   Ensembl; ENSBTAT00000015579; ENSBTAP00000015579; ENSBTAG00000011730.
DR   GeneID; 513257; -.
DR   KEGG; bta:513257; -.
DR   CTD; 8557; -.
DR   VEuPathDB; HostDB:ENSBTAG00000011730; -.
DR   VGNC; VGNC:35678; TCAP.
DR   eggNOG; ENOG502S21D; Eukaryota.
DR   GeneTree; ENSGT00390000012014; -.
DR   HOGENOM; CLU_128806_0_0_1; -.
DR   InParanoid; Q6T8D8; -.
DR   OMA; PWLLMRM; -.
DR   OrthoDB; 1270613at2759; -.
DR   TreeFam; TF333228; -.
DR   Reactome; R-BTA-390522; Striated Muscle Contraction.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000011730; Expressed in laryngeal cartilage and 102 other tissues.
DR   GO; GO:1990733; C:titin-telethonin complex; IEA:Ensembl.
DR   GO; GO:0030018; C:Z disc; IBA:GO_Central.
DR   GO; GO:0036122; F:BMP binding; IEA:Ensembl.
DR   GO; GO:0051373; F:FATZ binding; IEA:Ensembl.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central.
DR   GO; GO:0008307; F:structural constituent of muscle; IBA:GO_Central.
DR   GO; GO:0031432; F:titin binding; IBA:GO_Central.
DR   GO; GO:0070080; F:titin Z domain binding; IBA:GO_Central.
DR   GO; GO:0044325; F:transmembrane transporter binding; IEA:Ensembl.
DR   GO; GO:0007512; P:adult heart development; IEA:Ensembl.
DR   GO; GO:0060048; P:cardiac muscle contraction; IBA:GO_Central.
DR   GO; GO:0014898; P:cardiac muscle hypertrophy in response to stress; IEA:Ensembl.
DR   GO; GO:0055008; P:cardiac muscle tissue morphogenesis; IBA:GO_Central.
DR   GO; GO:0055003; P:cardiac myofibril assembly; IBA:GO_Central.
DR   GO; GO:0035995; P:detection of muscle stretch; IBA:GO_Central.
DR   GO; GO:0030916; P:otic vesicle formation; IEA:Ensembl.
DR   GO; GO:0045214; P:sarcomere organization; IEA:Ensembl.
DR   GO; GO:0048769; P:sarcomerogenesis; IBA:GO_Central.
DR   GO; GO:0003009; P:skeletal muscle contraction; IBA:GO_Central.
DR   GO; GO:0030241; P:skeletal muscle myosin thick filament assembly; IBA:GO_Central.
DR   GO; GO:0030240; P:skeletal muscle thin filament assembly; IBA:GO_Central.
DR   GO; GO:0001756; P:somitogenesis; IEA:Ensembl.
DR   Gene3D; 2.20.160.10; -; 1.
DR   InterPro; IPR015667; Telethonin.
DR   InterPro; IPR023111; Titin-like_dom_sf.
DR   PANTHER; PTHR15143; PTHR15143; 1.
DR   Pfam; PF09470; Telethonin; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Phosphoprotein; Reference proteome.
FT   CHAIN           1..166
FT                   /note="Telethonin"
FT                   /id="PRO_0000239294"
FT   REGION          145..166
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        151..166
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         39
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O70548"
SQ   SEQUENCE   166 AA;  18931 MW;  195CBF66A7C05328 CRC64;
     MATSELSCLV SEENCERREA FWAEWKDLTL STRPEEGCSL HEEDTQRHET YHRQGQCQAL
     VQRSPWLVMR MGILGRGLQE YQLPYQRVLP LPIFTPAKVG TKEEREETPI QLQELLALET
     ALGGQCVDRQ DVAEITKQLP PVVPVSKPGT LRRSLSRSMS QEAQRG