TELT_MOUSE
ID TELT_MOUSE Reviewed; 167 AA.
AC O70548;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Telethonin;
DE AltName: Full=Titin cap protein;
GN Name=Tcap;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Diaphragm;
RA Ievolella C., Formentin E., Valle G., Lanfranchi G.;
RT "Skeletal muscle transcripts characterization in Homo sapiens and Mus
RT musculus.";
RL Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Heart;
RA Kolmerer B.;
RT "The titin cap protein - a novel protein essential for sarcomere
RT formation.";
RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Muscle assembly regulating factor. Mediates the antiparallel
CC assembly of titin (TTN) molecules at the sarcomeric Z-disk (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with MYOZ1, MYOZ2 and MYOZ3. Interacts with CSRP3.
CC Interacts directly with the N-terminal Ig-like domains of 2 titin (TTN)
CC molecules. Interacts with ANKRD2; the interaction is direct (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere.
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DR EMBL; AJ223854; CAA11585.1; -; mRNA.
DR EMBL; Y15845; CAB38077.1; -; mRNA.
DR EMBL; BC027631; AAH27631.1; -; mRNA.
DR CCDS; CCDS25346.1; -.
DR RefSeq; NP_035670.2; NM_011540.2.
DR AlphaFoldDB; O70548; -.
DR SMR; O70548; -.
DR BioGRID; 203994; 1.
DR ComplexPortal; CPX-127; Titin-Telethonin complex.
DR STRING; 10090.ENSMUSP00000008021; -.
DR iPTMnet; O70548; -.
DR PhosphoSitePlus; O70548; -.
DR PaxDb; O70548; -.
DR PRIDE; O70548; -.
DR ProteomicsDB; 263033; -.
DR Antibodypedia; 3888; 221 antibodies from 29 providers.
DR DNASU; 21393; -.
DR Ensembl; ENSMUST00000008021; ENSMUSP00000008021; ENSMUSG00000007877.
DR GeneID; 21393; -.
DR KEGG; mmu:21393; -.
DR UCSC; uc007lgf.1; mouse.
DR CTD; 8557; -.
DR MGI; MGI:1330233; Tcap.
DR VEuPathDB; HostDB:ENSMUSG00000007877; -.
DR eggNOG; ENOG502S21D; Eukaryota.
DR GeneTree; ENSGT00390000012014; -.
DR HOGENOM; CLU_128806_0_0_1; -.
DR InParanoid; O70548; -.
DR OMA; PWLLMRM; -.
DR OrthoDB; 1270613at2759; -.
DR PhylomeDB; O70548; -.
DR TreeFam; TF333228; -.
DR Reactome; R-MMU-390522; Striated Muscle Contraction.
DR BioGRID-ORCS; 21393; 5 hits in 72 CRISPR screens.
DR ChiTaRS; Tcap; mouse.
DR PRO; PR:O70548; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; O70548; protein.
DR Bgee; ENSMUSG00000007877; Expressed in hindlimb stylopod muscle and 99 other tissues.
DR ExpressionAtlas; O70548; baseline and differential.
DR Genevisible; O70548; MM.
DR GO; GO:0031674; C:I band; IDA:BHF-UCL.
DR GO; GO:1990733; C:titin-telethonin complex; ISO:MGI.
DR GO; GO:0030018; C:Z disc; IDA:BHF-UCL.
DR GO; GO:0036122; F:BMP binding; ISO:MGI.
DR GO; GO:0051373; F:FATZ binding; ISO:MGI.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; ISO:MGI.
DR GO; GO:0008307; F:structural constituent of muscle; ISO:MGI.
DR GO; GO:0031432; F:titin binding; ISO:MGI.
DR GO; GO:0070080; F:titin Z domain binding; ISO:MGI.
DR GO; GO:0044325; F:transmembrane transporter binding; ISO:MGI.
DR GO; GO:0007512; P:adult heart development; IEP:BHF-UCL.
DR GO; GO:0055013; P:cardiac muscle cell development; ISO:MGI.
DR GO; GO:0060048; P:cardiac muscle contraction; ISO:MGI.
DR GO; GO:0003300; P:cardiac muscle hypertrophy; ISO:MGI.
DR GO; GO:0014898; P:cardiac muscle hypertrophy in response to stress; ISO:MGI.
DR GO; GO:0055008; P:cardiac muscle tissue morphogenesis; ISO:MGI.
DR GO; GO:0055003; P:cardiac myofibril assembly; ISO:MGI.
DR GO; GO:0035995; P:detection of muscle stretch; ISO:MGI.
DR GO; GO:0030916; P:otic vesicle formation; IEP:BHF-UCL.
DR GO; GO:0045214; P:sarcomere organization; ISO:MGI.
DR GO; GO:0048769; P:sarcomerogenesis; ISO:MGI.
DR GO; GO:0003009; P:skeletal muscle contraction; IBA:GO_Central.
DR GO; GO:0030241; P:skeletal muscle myosin thick filament assembly; ISO:MGI.
DR GO; GO:0030240; P:skeletal muscle thin filament assembly; ISO:MGI.
DR GO; GO:0001756; P:somitogenesis; IEP:BHF-UCL.
DR Gene3D; 2.20.160.10; -; 1.
DR InterPro; IPR015667; Telethonin.
DR InterPro; IPR023111; Titin-like_dom_sf.
DR PANTHER; PTHR15143; PTHR15143; 1.
DR Pfam; PF09470; Telethonin; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Phosphoprotein; Reference proteome.
FT CHAIN 1..167
FT /note="Telethonin"
FT /id="PRO_0000072484"
FT REGION 142..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 39
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 167 AA; 19078 MW; 2CB1F6F5415B4DC1 CRC64;
MATSELSCQV SEENQERREA FWAEWKDLTL STRPEEGCSL HEEDTQRHET YHRQGQCQAV
VQRSPWLVMR LGILGRGLQE YQLPYQRVLP LPIFTPTKVG ASKEEREETP IQLRELLALE
TALGGQCVER QDVAEITKQL PPVVPVSKPG PLRRTLSRSM SQEAQRG
