TEN1_ARATH
ID TEN1_ARATH Reviewed; 127 AA.
AC Q6NME7; Q9C7K1;
DT 13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=CST complex subunit TEN1 {ECO:0000303|PubMed:23572541};
DE AltName: Full=Protein MERISTEM DISORGANIZATION 1 {ECO:0000303|PubMed:21781195};
DE AltName: Full=Protein telomeric pathways with STN1 homolog {ECO:0000303|PubMed:23572541};
GN Name=TEN1 {ECO:0000303|PubMed:23572541};
GN Synonyms=MDO1 {ECO:0000303|PubMed:21781195};
GN OrderedLocusNames=At1g56260 {ECO:0000312|Araport:AT1G56260};
GN ORFNames=F14G9.13 {ECO:0000312|EMBL:AAG50904.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:AAS49076.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R., Chen H., Kim C.J., Shinn P., Carninci P., Hayashizaki Y.,
RA Ishida J., Kamiya A., Kawai J., Narusaka M., Sakurai T., Satou M., Seki M.,
RA Shinozaki K., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, MUTAGENESIS OF GLY-77, AND TISSUE SPECIFICITY.
RX PubMed=21781195; DOI=10.1111/j.1365-313x.2011.04718.x;
RA Hashimura Y., Ueguchi C.;
RT "The Arabidopsis MERISTEM DISORGANIZATION 1 gene is required for the
RT maintenance of stem cells through the reduction of DNA damage.";
RL Plant J. 68:657-669(2011).
RN [6]
RP FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH STN1, SUBCELLULAR LOCATION,
RP AND MUTAGENESIS OF GLY-77.
RX PubMed=23572541; DOI=10.1105/tpc.112.107425;
RA Leehy K.A., Lee J.R., Song X., Renfrew K.B., Shippen D.E.;
RT "MERISTEM DISORGANIZATION1 encodes TEN1, an essential telomere protein that
RT modulates telomerase processivity in Arabidopsis.";
RL Plant Cell 25:1343-1354(2013).
RN [7]
RP FUNCTION, AND INTERACTION WITH STN1 AND POT1A.
RX PubMed=25329641; DOI=10.1371/journal.pgen.1004738;
RA Renfrew K.B., Song X., Lee J.R., Arora A., Shippen D.E.;
RT "POT1a and components of CST engage telomerase and regulate its activity in
RT Arabidopsis.";
RL PLoS Genet. 10:E1004738-E1004738(2014).
CC -!- FUNCTION: Required for the maintenance of meristems and stem cells
CC through the reduction of DNA damage (PubMed:21781195). Promotes
CC telomere integrity by maintaining telomere length and proper
CC architecture of the chromosome terminus (PubMed:23572541). Negatively
CC regulates telomerase repeat addition processivity (PubMed:23572541).
CC Hampers contacts between enzymatically active telomerase and CST
CC complex (PubMed:25329641). {ECO:0000269|PubMed:21781195,
CC ECO:0000269|PubMed:23572541, ECO:0000269|PubMed:25329641}.
CC -!- SUBUNIT: Component of the CST complex, composed of CTC1, TEN1 and STN1.
CC Interacts with STN1 (PubMed:23572541, PubMed:25329641). No interaction
CC with POT1A, but competes with it for STN1 binding (PubMed:25329641).
CC {ECO:0000269|PubMed:23572541, ECO:0000269|PubMed:25329641}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23572541}.
CC Chromosome, telomere {ECO:0000269|PubMed:23572541}. Note=Associates
CC transiently with telomeres. {ECO:0000269|PubMed:23572541}.
CC -!- TISSUE SPECIFICITY: Ubiquitous (PubMed:21781195, PubMed:23572541). High
CC expression in meristematic tissues and in vasculature
CC (PubMed:21781195). {ECO:0000269|PubMed:21781195,
CC ECO:0000269|PubMed:23572541}.
CC -!- SIMILARITY: Belongs to the TEN1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG50904.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC069159; AAG50904.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE33370.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM59369.1; -; Genomic_DNA.
DR EMBL; BT011713; AAS49076.1; -; mRNA.
DR EMBL; AK221533; BAD94861.1; -; mRNA.
DR PIR; C96604; C96604.
DR RefSeq; NP_001321732.1; NM_001333774.1.
DR RefSeq; NP_176022.2; NM_104505.4.
DR AlphaFoldDB; Q6NME7; -.
DR SMR; Q6NME7; -.
DR STRING; 3702.AT1G56260.1; -.
DR PaxDb; Q6NME7; -.
DR PRIDE; Q6NME7; -.
DR ProteomicsDB; 234405; -.
DR DNASU; 842079; -.
DR EnsemblPlants; AT1G56260.1; AT1G56260.1; AT1G56260.
DR EnsemblPlants; AT1G56260.2; AT1G56260.2; AT1G56260.
DR GeneID; 842079; -.
DR Gramene; AT1G56260.1; AT1G56260.1; AT1G56260.
DR Gramene; AT1G56260.2; AT1G56260.2; AT1G56260.
DR KEGG; ath:AT1G56260; -.
DR Araport; AT1G56260; -.
DR TAIR; locus:2011781; AT1G56260.
DR eggNOG; ENOG502S1R3; Eukaryota.
DR HOGENOM; CLU_146825_0_0_1; -.
DR InParanoid; Q6NME7; -.
DR OMA; IQPNNEA; -.
DR OrthoDB; 1496976at2759; -.
DR PhylomeDB; Q6NME7; -.
DR PRO; PR:Q6NME7; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q6NME7; baseline and differential.
DR GO; GO:0000781; C:chromosome, telomeric region; IDA:TAIR.
DR GO; GO:1990879; C:CST complex; IBA:GO_Central.
DR GO; GO:0044183; F:protein folding chaperone; IDA:TAIR.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR GO; GO:0010521; F:telomerase inhibitor activity; IDA:TAIR.
DR GO; GO:0042162; F:telomeric DNA binding; IBA:GO_Central.
DR GO; GO:0032211; P:negative regulation of telomere maintenance via telomerase; IBA:GO_Central.
DR GO; GO:0009408; P:response to heat; IMP:TAIR.
DR GO; GO:0048367; P:shoot system development; IMP:TAIR.
DR GO; GO:0019827; P:stem cell population maintenance; IMP:TAIR.
DR GO; GO:0000723; P:telomere maintenance; IMP:TAIR.
DR Gene3D; 2.40.50.140; -; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR029146; Ten1_animal_plant.
DR PANTHER; PTHR33905; PTHR33905; 1.
DR Pfam; PF15490; Ten1_2; 1.
PE 1: Evidence at protein level;
KW Chromosome; Nucleus; Reference proteome; Telomere.
FT CHAIN 1..127
FT /note="CST complex subunit TEN1"
FT /id="PRO_0000436042"
FT MUTAGEN 77
FT /note="G->E: In mdo1-1/ten1-3; strong developmental defects
FT and loss of in vitro interaction with STN1."
FT /evidence="ECO:0000269|PubMed:21781195,
FT ECO:0000269|PubMed:23572541"
SQ SEQUENCE 127 AA; 14378 MW; F67E791AAA30A2B0 CRC64;
MAKSQIEPGV PITLQELYPS SLFYKEGVSL RVTAMLRGYS VETAIGVIED GGRSLKINTQ
NIRDVSFRVG SIYQFIGELH IEQPNNEAIL QARTGRNVDG IDMNLYRKTI ELLRQFLKEE
DNSNMVE
