TEN1_YEAST
ID TEN1_YEAST Reviewed; 160 AA.
AC Q07921; D6VY12;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Telomere length regulation protein TEN1;
DE AltName: Full=Protein telomeric pathways with STN1;
GN Name=TEN1; OrderedLocusNames=YLR010C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND INTERACTION WITH CDC13 AND
RP STN1.
RX PubMed=11230140; DOI=10.1093/emboj/20.5.1173;
RA Grandin N., Damon C., Charbonneau M.;
RT "Ten1 functions in telomere end protection and length regulation in
RT association with Stn1 and Cdc13.";
RL EMBO J. 20:1173-1183(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169871;
RA Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA Zollner A., Hani J., Hoheisel J.D.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL Nature 387:87-90(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
CC -!- FUNCTION: Has a role in telomere length regulation and telomere end
CC protection. Acts as an inhibitor of telomerase loading through its
CC interaction with CDC13. {ECO:0000269|PubMed:11230140}.
CC -!- SUBUNIT: Interacts with CDC13 and STN1. {ECO:0000269|PubMed:11230140}.
CC -!- INTERACTION:
CC Q07921; P38960: STN1; NbExp=12; IntAct=EBI-35131, EBI-18427;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Chromosome, telomere
CC {ECO:0000305}.
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DR EMBL; AJ296344; CAC24568.1; -; Genomic_DNA.
DR EMBL; Z73182; CAA97532.1; -; Genomic_DNA.
DR EMBL; AY558198; AAS56524.1; -; Genomic_DNA.
DR EMBL; BK006945; DAA09328.1; -; Genomic_DNA.
DR PIR; S64832; S64832.
DR RefSeq; NP_013110.1; NM_001181897.1.
DR AlphaFoldDB; Q07921; -.
DR SMR; Q07921; -.
DR BioGRID; 31283; 25.
DR ComplexPortal; CPX-15; CST complex.
DR DIP; DIP-5926N; -.
DR IntAct; Q07921; 2.
DR STRING; 4932.YLR010C; -.
DR PaxDb; Q07921; -.
DR TopDownProteomics; Q07921; -.
DR EnsemblFungi; YLR010C_mRNA; YLR010C; YLR010C.
DR GeneID; 850696; -.
DR KEGG; sce:YLR010C; -.
DR SGD; S000004000; TEN1.
DR VEuPathDB; FungiDB:YLR010C; -.
DR HOGENOM; CLU_1653134_0_0_1; -.
DR InParanoid; Q07921; -.
DR OMA; XSDEEFI; -.
DR BioCyc; YEAST:G3O-32171-MON; -.
DR PRO; PR:Q07921; -.
DR Proteomes; UP000002311; Chromosome XII.
DR RNAct; Q07921; protein.
DR GO; GO:0000781; C:chromosome, telomeric region; IC:ComplexPortal.
DR GO; GO:1990879; C:CST complex; IPI:SGD.
DR GO; GO:0043047; F:single-stranded telomeric DNA binding; IDA:SGD.
DR GO; GO:0003711; F:transcription elongation regulator activity; IMP:SGD.
DR GO; GO:0061770; F:translation elongation factor binding; IDA:SGD.
DR GO; GO:0051974; P:negative regulation of telomerase activity; IC:ComplexPortal.
DR GO; GO:0032205; P:negative regulation of telomere maintenance; IMP:SGD.
DR GO; GO:0032210; P:regulation of telomere maintenance via telomerase; IC:ComplexPortal.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IMP:SGD.
DR GO; GO:0016233; P:telomere capping; IMP:SGD.
DR GO; GO:0007004; P:telomere maintenance via telomerase; IMP:SGD.
PE 1: Evidence at protein level;
KW Chromosome; Nucleus; Reference proteome; Telomere.
FT CHAIN 1..160
FT /note="Telomere length regulation protein TEN1"
FT /id="PRO_0000270926"
SQ SEQUENCE 160 AA; 18605 MW; 0D8152451821E2CE CRC64;
MSQLVLDLKC LKDKIATNYD IHNNVYGGNG MEPNIIHPSK RFRIVVRLVD FLFCKSDEEF
IKGFFCQMIV RNLHCLNSTN GAEEMRLYMS ERLFSAHKDD LRLINGQVLD VRIGVWYGIH
QSPPIFEIID FKILSRNDVR DFCEFVKSPL GEKFLNISNS
