ID   TEN3_TENMO              Reviewed;          96 AA.
AC   Q27270;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Tenecin-3;
DE   Flags: Precursor;
OS   Tenebrio molitor (Yellow mealworm beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Tenebrionidae; Tenebrio.
OX   NCBI_TaxID=7067;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Larva;
RX   PubMed=8573176; DOI=10.1006/bbrc.1996.0002;
RA   Lee Y.J., Chung T.J., Park C.W., Hahn Y., Chung J.H., Lee B.L., Han D.M.,
RA   Jung Y.H., Kim S., Lee Y.;
RT   "Structure and expression of the tenecin 3 gene in Tenebrio molitor.";
RL   Biochem. Biophys. Res. Commun. 218:6-11(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE, AND PROTEIN SEQUENCE OF 19-43.
RC   TISSUE=Hemolymph;
RA   Jung H.Y., Park B.Y., Lee D.-K., Hahn Y., Chung J.H., Han D.M., Moon H.J.,
RA   Lee B.L., Lee Y.;
RT   "Biochemical and molecular characterization of an antifungal protein from
RT   Tenebrio molitor larvae.";
RL   Mol. Cells 5:287-292(1995).
CC   -!- FUNCTION: Antifungal heat stable protein produced in response to
CC       injury. It is active against C.albicans. No antibacterial activity
CC       against Gram-positive and Gram-negative bacteria.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- DEVELOPMENTAL STAGE: Highest expression in larvae and adult. To a much
CC       lesser extent in pupae.
CC   -!- SIMILARITY: To H.diomphalia holotricin 3. {ECO:0000305}.
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DR   EMBL; U30627; AAA97579.1; -; Genomic_DNA.
DR   EMBL; U21482; AAB01064.1; -; mRNA.
DR   PIR; JC4581; JC4581.
DR   AlphaFoldDB; Q27270; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Fungicide; Immunity;
KW   Innate immunity; Repeat; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000269|Ref.2"
FT   CHAIN           19..96
FT                   /note="Tenecin-3"
FT                   /id="PRO_0000004991"
FT   REPEAT          23..26
FT                   /note="1"
FT   REPEAT          31..34
FT                   /note="2"
FT   REPEAT          35..38
FT                   /note="3"
FT   REPEAT          39..42
FT                   /note="4"
FT   REPEAT          43..46
FT                   /note="5"
FT   REPEAT          47..50
FT                   /note="6"
FT   REPEAT          51..54
FT                   /note="7"
FT   REPEAT          59..62
FT                   /note="8"
FT   REPEAT          63..66
FT                   /note="9"
FT   REPEAT          67..70
FT                   /note="10"
FT   REPEAT          77..80
FT                   /note="11"
FT   REPEAT          86..89
FT                   /note="12"
FT   REGION          19..96
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          23..89
FT                   /note="12 X 4 AA repeats of G-X-X-G"
SQ   SEQUENCE   96 AA;  9295 MW;  4254EFBA59F94D9B CRC64;
     MKTFVICLIL VVAVSAAPDH HDGHLGGHQT GHQGGQQGGH LGGQQGGHLG GHQGGQPGGH
     LGGHQGGIGG TGGQQHGQHG PGTGAGHQGG YKTHGH