TEN4_HUMAN
ID TEN4_HUMAN Reviewed; 2769 AA.
AC Q6N022; A6ND26; Q7Z3C7; Q96MS6; Q9P2P4; Q9Y4S2;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Teneurin-4;
DE Short=Ten-4;
DE AltName: Full=Protein Odd Oz/ten-m homolog 4;
DE AltName: Full=Tenascin-M4;
DE Short=Ten-m4;
DE AltName: Full=Teneurin transmembrane protein 4;
GN Name=TENM4; Synonyms=KIAA1302, ODZ4, TNM4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 754-2769.
RC TISSUE=Brain;
RX PubMed=10718198; DOI=10.1093/dnares/7.1.65;
RA Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVI. The
RT complete sequences of 150 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:65-73(2000).
RN [3]
RP SEQUENCE REVISION.
RX PubMed=12168954; DOI=10.1093/dnares/9.3.99;
RA Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT "Construction of expression-ready cDNA clones for KIAA genes: manual
RT curation of 330 KIAA cDNA clones.";
RL DNA Res. 9:99-106(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1371-2769.
RC TISSUE=Brain, Cervix, and Fetal kidney;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2040-2715.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [7]
RP FUNCTION, SUBCELLULAR LOCATION, INVOLVEMENT IN ETM5, VARIANTS ETM5 PRO-53;
RP ASP-474; GLN-518; MET-1128; MET-1138; ASN-1367; THR-1442; GLN-1535;
RP HIS-1632; ARG-1763 AND ILE-2451, AND CHARACTERIZATION OF VARIANTS ETM5
RP MET-1138; ASN-1367 AND THR-1442.
RX PubMed=26188006; DOI=10.1093/hmg/ddv281;
RA Hor H., Francescatto L., Bartesaghi L., Ortega-Cubero S., Kousi M.,
RA Lorenzo-Betancor O., Jimenez-Jimenez F.J., Gironell A., Clarimon J.,
RA Drechsel O., Agundez J.A., Kenzelmann Broz D., Chiquet-Ehrismann R.,
RA Lleo A., Coria F., Garcia-Martin E., Alonso-Navarro H., Marti M.J.,
RA Kulisevsky J., Hor C.N., Ossowski S., Chrast R., Katsanis N., Pastor P.,
RA Estivill X.;
RT "Missense mutations in TENM4, a regulator of axon guidance and central
RT myelination, cause essential tremor.";
RL Hum. Mol. Genet. 24:5677-5686(2015).
RN [8]
RP VARIANT GLU-519.
RX PubMed=30976112; DOI=10.1038/s41431-019-0380-y;
RA Harel T., Levy-Lahad E., Daana M., Mechoulam H., Horowitz-Cederboim S.,
RA Gur M., Meiner V., Elpeleg O.;
RT "Homozygous stop-gain variant in LRRC32, encoding a TGFbeta receptor,
RT associated with cleft palate, proliferative retinopathy, and developmental
RT delay.";
RL Eur. J. Hum. Genet. 27:1315-1319(2019).
CC -!- FUNCTION: Involved in neural development, regulating the establishment
CC of proper connectivity within the nervous system. Plays a role in the
CC establishment of the anterior-posterior axis during gastrulation.
CC Regulates the differentiation and cellular process formation of
CC oligodendrocytes and myelination of small-diameter axons in the central
CC nervous system (CNS) (PubMed:26188006). Promotes activation of focal
CC adhesion kinase. May function as a cellular signal transducer (By
CC similarity). {ECO:0000250|UniProtKB:Q3UHK6,
CC ECO:0000269|PubMed:26188006}.
CC -!- SUBUNIT: Homodimer; disulfide-linked (Probable). May also form
CC heterodimer with either TENM1 or TENM2 or TENM3 (By similarity).
CC {ECO:0000250, ECO:0000305}.
CC -!- INTERACTION:
CC Q6N022; Q92608: DOCK2; NbExp=3; IntAct=EBI-12827077, EBI-448771;
CC Q6N022; P17482: HOXB9; NbExp=3; IntAct=EBI-12827077, EBI-745290;
CC Q6N022; Q9BYE3: LCE3D; NbExp=3; IntAct=EBI-12827077, EBI-6658837;
CC Q6N022; P56470: LGALS4; NbExp=3; IntAct=EBI-12827077, EBI-720805;
CC Q6N022; Q9NRQ2: PLSCR4; NbExp=3; IntAct=EBI-12827077, EBI-769257;
CC Q6N022; Q9NUL5-4: SHFL; NbExp=3; IntAct=EBI-12827077, EBI-11955083;
CC Q6N022; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-12827077, EBI-6427977;
CC Q6N022; Q9H7X3: ZNF696; NbExp=3; IntAct=EBI-12827077, EBI-11090299;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26188006};
CC Single-pass membrane protein {ECO:0000255}. Cell projection
CC {ECO:0000250|UniProtKB:Q3UHK6}. Nucleus {ECO:0000250|UniProtKB:Q3UHK6}.
CC Cytoplasm {ECO:0000250|UniProtKB:Q3UHK6}.
CC -!- DOMAIN: EGF-like domains 2 and 5 which have an odd number of cysteines
CC might enable the formation of intermolecular disulfide bonds.
CC -!- DOMAIN: Cytoplasmic proline-rich regions could serve as docking domains
CC for intracellular SH3-containing proteins.
CC -!- DISEASE: Tremor, hereditary essential 5 (ETM5) [MIM:616736]: A common
CC movement disorder mainly characterized by postural tremor of the arms.
CC Head, legs, trunk, voice, jaw, and facial muscles also may be involved.
CC The condition can be aggravated by emotions, hunger, fatigue and
CC temperature extremes, and may cause a functional disability or even
CC incapacitation. Inheritance is autosomal dominant.
CC {ECO:0000269|PubMed:26188006}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
CC -!- SIMILARITY: Belongs to the tenascin family. Teneurin subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB71206.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AP002515; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP002768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP002958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP002957; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB037723; BAA92540.3; -; mRNA.
DR EMBL; BX640737; CAE45850.1; -; mRNA.
DR EMBL; AL080120; CAB45719.1; -; mRNA.
DR EMBL; BX537983; CAD97943.1; -; mRNA.
DR EMBL; AK056531; BAB71206.1; ALT_INIT; mRNA.
DR CCDS; CCDS44688.1; -.
DR PIR; T12457; T12457.
DR RefSeq; NP_001092286.2; NM_001098816.2.
DR RefSeq; XP_016873015.1; XM_017017526.1.
DR PDB; 7BAM; EM; 3.50 A; A/B=834-2765.
DR PDB; 7BAN; EM; 2.70 A; A/B=834-2765.
DR PDB; 7BAO; EM; 2.70 A; A=834-2765.
DR PDB; 7PLP; X-ray; 1.40 A; A/B=833-871.
DR PDBsum; 7BAM; -.
DR PDBsum; 7BAN; -.
DR PDBsum; 7BAO; -.
DR PDBsum; 7PLP; -.
DR SASBDB; Q6N022; -.
DR SMR; Q6N022; -.
DR BioGRID; 117484; 18.
DR IntAct; Q6N022; 10.
DR STRING; 9606.ENSP00000278550; -.
DR CarbonylDB; Q6N022; -.
DR GlyGen; Q6N022; 13 sites, 1 O-linked glycan (1 site).
DR iPTMnet; Q6N022; -.
DR PhosphoSitePlus; Q6N022; -.
DR BioMuta; TENM4; -.
DR DMDM; 117949795; -.
DR jPOST; Q6N022; -.
DR MassIVE; Q6N022; -.
DR MaxQB; Q6N022; -.
DR PaxDb; Q6N022; -.
DR PeptideAtlas; Q6N022; -.
DR PRIDE; Q6N022; -.
DR ProteomicsDB; 66601; -.
DR Antibodypedia; 67208; 12 antibodies from 6 providers.
DR DNASU; 26011; -.
DR Ensembl; ENST00000278550.12; ENSP00000278550.7; ENSG00000149256.16.
DR GeneID; 26011; -.
DR KEGG; hsa:26011; -.
DR MANE-Select; ENST00000278550.12; ENSP00000278550.7; NM_001098816.3; NP_001092286.2.
DR UCSC; uc001ozl.5; human.
DR CTD; 26011; -.
DR DisGeNET; 26011; -.
DR GeneCards; TENM4; -.
DR HGNC; HGNC:29945; TENM4.
DR HPA; ENSG00000149256; Tissue enhanced (brain, ovary, parathyroid gland).
DR MalaCards; TENM4; -.
DR MIM; 610084; gene.
DR MIM; 616736; phenotype.
DR neXtProt; NX_Q6N022; -.
DR OpenTargets; ENSG00000149256; -.
DR Orphanet; 862; NON RARE IN EUROPE: Hereditary essential tremor.
DR PharmGKB; PA134896466; -.
DR VEuPathDB; HostDB:ENSG00000149256; -.
DR eggNOG; KOG4659; Eukaryota.
DR GeneTree; ENSGT01030000234566; -.
DR HOGENOM; CLU_000229_0_0_1; -.
DR InParanoid; Q6N022; -.
DR OMA; HWTQSAP; -.
DR OrthoDB; 7516at2759; -.
DR PhylomeDB; Q6N022; -.
DR TreeFam; TF316833; -.
DR PathwayCommons; Q6N022; -.
DR SignaLink; Q6N022; -.
DR BioGRID-ORCS; 26011; 15 hits in 1067 CRISPR screens.
DR ChiTaRS; TENM4; human.
DR GeneWiki; ODZ4; -.
DR GenomeRNAi; 26011; -.
DR Pharos; Q6N022; Tbio.
DR PRO; PR:Q6N022; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q6N022; protein.
DR Bgee; ENSG00000149256; Expressed in hair follicle and 154 other tissues.
DR ExpressionAtlas; Q6N022; baseline and differential.
DR Genevisible; Q6N022; HS.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
DR GO; GO:0043005; C:neuron projection; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0050839; F:cell adhesion molecule binding; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0060912; P:cardiac cell fate specification; IEA:Ensembl.
DR GO; GO:0060038; P:cardiac muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0032289; P:central nervous system myelin formation; IMP:UniProtKB.
DR GO; GO:0001702; P:gastrulation with mouth forming second; IEA:Ensembl.
DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IBA:GO_Central.
DR GO; GO:0048666; P:neuron development; IMP:UniProtKB.
DR GO; GO:2000543; P:positive regulation of gastrulation; ISS:UniProtKB.
DR GO; GO:0031643; P:positive regulation of myelination; ISS:UniProtKB.
DR GO; GO:0048714; P:positive regulation of oligodendrocyte differentiation; ISS:UniProtKB.
DR GO; GO:0031641; P:regulation of myelination; IMP:UniProtKB.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 2.120.10.30; -; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR022385; Rhs_assc_core.
DR InterPro; IPR027691; Ten-3/4.
DR InterPro; IPR009471; Ten_N.
DR InterPro; IPR028916; Tox-GHH_dom.
DR InterPro; IPR006530; YD.
DR PANTHER; PTHR11219:SF65; PTHR11219:SF65; 1.
DR Pfam; PF07974; EGF_2; 2.
DR Pfam; PF06484; Ten_N; 2.
DR Pfam; PF15636; Tox-GHH; 1.
DR SMART; SM00181; EGF; 8.
DR SUPFAM; SSF49464; SSF49464; 1.
DR TIGRFAMs; TIGR03696; Rhs_assc_core; 1.
DR TIGRFAMs; TIGR01643; YD_repeat_2x; 2.
DR PROSITE; PS00022; EGF_1; 8.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS51361; TENEURIN_N; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Cell projection; Cytoplasm;
KW Developmental protein; Differentiation; Disease variant; Disulfide bond;
KW EGF-like domain; Glycoprotein; Membrane; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..2769
FT /note="Teneurin-4"
FT /id="PRO_0000259508"
FT TOPO_DOM 1..345
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 346..366
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 367..2769
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 1..341
FT /note="Teneurin N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00694"
FT DOMAIN 562..593
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 594..624
FT /note="EGF-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 626..658
FT /note="EGF-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 659..690
FT /note="EGF-like 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 692..725
FT /note="EGF-like 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 726..757
FT /note="EGF-like 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 758..787
FT /note="EGF-like 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 788..831
FT /note="EGF-like 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REPEAT 1216..1259
FT /note="NHL 1"
FT REPEAT 1264..1308
FT /note="NHL 2"
FT REPEAT 1334..1378
FT /note="NHL 3"
FT REPEAT 1393..1444
FT /note="NHL 4"
FT REPEAT 1523..1566
FT /note="NHL 5"
FT REPEAT 1576..1595
FT /note="YD 1"
FT REPEAT 1612..1632
FT /note="YD 2"
FT REPEAT 1675..1694
FT /note="YD 3"
FT REPEAT 1695..1717
FT /note="YD 4"
FT REPEAT 1887..1906
FT /note="YD 5"
FT REPEAT 1928..1946
FT /note="YD 6"
FT REPEAT 1947..1967
FT /note="YD 7"
FT REPEAT 1974..1991
FT /note="YD 8"
FT REPEAT 1992..2013
FT /note="YD 9"
FT REPEAT 2014..2031
FT /note="YD 10"
FT REPEAT 2034..2054
FT /note="YD 11"
FT REPEAT 2057..2077
FT /note="YD 12"
FT REPEAT 2085..2104
FT /note="YD 13"
FT REPEAT 2110..2127
FT /note="YD 14"
FT REPEAT 2128..2154
FT /note="YD 15"
FT REPEAT 2156..2169
FT /note="YD 16"
FT REPEAT 2170..2193
FT /note="YD 17"
FT REPEAT 2196..2216
FT /note="YD 18"
FT REPEAT 2217..2237
FT /note="YD 19"
FT REPEAT 2239..2259
FT /note="YD 20"
FT REPEAT 2271..2291
FT /note="YD 21"
FT REPEAT 2293..2313
FT /note="YD 22"
FT REPEAT 2339..2380
FT /note="YD 23"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 130..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 507..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..526
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 124
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3UHK6"
FT MOD_RES 178
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q3UHK6"
FT CARBOHYD 467
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 940
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1259
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1609
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1705
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1741
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1799
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1884
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1985
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2188
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2328
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2646
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 566..576
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 570..581
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 583..592
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 601..612
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 614..623
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 630..641
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 635..646
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 648..657
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 662..673
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 667..678
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 680..689
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 700..713
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 715..724
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 729..739
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 733..744
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 746..755
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 760..770
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 764..775
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 777..786
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 800..810
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 804..819
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 821..830
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT VARIANT 14
FT /note="R -> Q (in dbSNP:rs58537389)"
FT /id="VAR_062167"
FT VARIANT 53
FT /note="R -> P (in ETM5; unknown pathological significance;
FT dbSNP:rs760852624)"
FT /evidence="ECO:0000269|PubMed:26188006"
FT /id="VAR_076654"
FT VARIANT 396
FT /note="V -> I (in dbSNP:rs3812723)"
FT /id="VAR_060130"
FT VARIANT 474
FT /note="A -> D (in ETM5; unknown pathological significance)"
FT /evidence="ECO:0000269|PubMed:26188006"
FT /id="VAR_076655"
FT VARIANT 506
FT /note="E -> Q (in dbSNP:rs17137261)"
FT /id="VAR_060131"
FT VARIANT 518
FT /note="R -> Q (in ETM5; unknown pathological significance;
FT dbSNP:rs201191369)"
FT /evidence="ECO:0000269|PubMed:26188006"
FT /id="VAR_076656"
FT VARIANT 519
FT /note="G -> E (found in a patiend with developmental delay,
FT cleft palate and proliferative retinopathy; unknown
FT pathological significance; dbSNP:rs1591072819)"
FT /evidence="ECO:0000269|PubMed:30976112"
FT /id="VAR_085138"
FT VARIANT 1128
FT /note="V -> M (in ETM5; unknown pathological significance;
FT dbSNP:rs556858741)"
FT /evidence="ECO:0000269|PubMed:26188006"
FT /id="VAR_076657"
FT VARIANT 1138
FT /note="V -> M (in ETM5; dominant negative effect on central
FT nervous myelination and axon guidance; changed localization
FT to the plasma membrane; clustered plasma membrane
FT localization; dbSNP:rs538881762)"
FT /evidence="ECO:0000269|PubMed:26188006"
FT /id="VAR_076521"
FT VARIANT 1367
FT /note="T -> N (in ETM5; dominant negative effect on central
FT nervous myelination and axon guidance; changed localization
FT to the plasma membrane; clustered plasma membrane
FT localization; dbSNP:rs763485258)"
FT /evidence="ECO:0000269|PubMed:26188006"
FT /id="VAR_076522"
FT VARIANT 1442
FT /note="A -> T (in ETM5; dominant negative effect on central
FT nervous myelination and axon guidance; changed localization
FT to the plasma membrane; clustered plasma membrane
FT localization; dbSNP:rs375681722)"
FT /evidence="ECO:0000269|PubMed:26188006"
FT /id="VAR_076523"
FT VARIANT 1535
FT /note="K -> Q (in ETM5; unknown pathological significance;
FT dbSNP:rs770111861)"
FT /evidence="ECO:0000269|PubMed:26188006"
FT /id="VAR_076658"
FT VARIANT 1632
FT /note="R -> H (in ETM5; unknown pathological significance;
FT dbSNP:rs199687168)"
FT /evidence="ECO:0000269|PubMed:26188006"
FT /id="VAR_076659"
FT VARIANT 1763
FT /note="G -> R (in ETM5; unknown pathological significance;
FT dbSNP:rs201995608)"
FT /evidence="ECO:0000269|PubMed:26188006"
FT /id="VAR_076660"
FT VARIANT 2451
FT /note="M -> I (in ETM5; unknown pathological significance;
FT dbSNP:rs201769315)"
FT /evidence="ECO:0000269|PubMed:26188006"
FT /id="VAR_076661"
FT CONFLICT 1471
FT /note="T -> I (in Ref. 4; CAE45850)"
FT /evidence="ECO:0000305"
FT CONFLICT 1842
FT /note="D -> G (in Ref. 4; CAD97943)"
FT /evidence="ECO:0000305"
FT CONFLICT 2024
FT /note="L -> F (in Ref. 4; CAD97943)"
FT /evidence="ECO:0000305"
FT CONFLICT 2393
FT /note="N -> D (in Ref. 4; CAE45850)"
FT /evidence="ECO:0000305"
FT CONFLICT 2551
FT /note="Q -> L (in Ref. 5; BAB71206)"
FT /evidence="ECO:0000305"
FT CONFLICT 2586
FT /note="V -> G (in Ref. 4; CAB45719)"
FT /evidence="ECO:0000305"
FT CONFLICT 2599
FT /note="N -> D (in Ref. 4; CAB45719)"
FT /evidence="ECO:0000305"
FT CONFLICT 2657
FT /note="N -> S (in Ref. 5; BAB71206)"
FT /evidence="ECO:0000305"
FT STRAND 839..842
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 846..848
FT /evidence="ECO:0007829|PDB:7BAN"
FT HELIX 851..853
FT /evidence="ECO:0007829|PDB:7BAN"
FT HELIX 855..859
FT /evidence="ECO:0007829|PDB:7BAN"
FT TURN 861..865
FT /evidence="ECO:0007829|PDB:7BAN"
FT TURN 867..869
FT /evidence="ECO:0007829|PDB:7BAN"
FT HELIX 875..880
FT /evidence="ECO:0007829|PDB:7BAN"
FT HELIX 895..899
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 906..909
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 911..913
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 921..929
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 931..933
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 940..945
FT /evidence="ECO:0007829|PDB:7BAN"
FT HELIX 947..949
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 951..953
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 958..968
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 971..975
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 982..985
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 990..995
FT /evidence="ECO:0007829|PDB:7BAN"
FT TURN 1006..1009
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1022..1025
FT /evidence="ECO:0007829|PDB:7BAN"
FT TURN 1036..1038
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1040..1042
FT /evidence="ECO:0007829|PDB:7BAN"
FT TURN 1043..1046
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1047..1053
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1055..1058
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1060..1064
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1073..1078
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1088..1097
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1100..1107
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1113..1118
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1129..1144
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1150..1159
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1171..1173
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1178..1180
FT /evidence="ECO:0007829|PDB:7BAN"
FT TURN 1181..1184
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1185..1187
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1193..1195
FT /evidence="ECO:0007829|PDB:7BAN"
FT HELIX 1196..1198
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1221..1224
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1235..1237
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1243..1246
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1248..1254
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1258..1265
FT /evidence="ECO:0007829|PDB:7BAN"
FT HELIX 1272..1275
FT /evidence="ECO:0007829|PDB:7BAN"
FT HELIX 1277..1279
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1283..1285
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1287..1289
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1292..1294
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1297..1305
FT /evidence="ECO:0007829|PDB:7BAN"
FT TURN 1314..1316
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1319..1323
FT /evidence="ECO:0007829|PDB:7BAN"
FT TURN 1336..1339
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1350..1355
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1361..1365
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1374..1377
FT /evidence="ECO:0007829|PDB:7BAN"
FT HELIX 1401..1403
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1411..1415
FT /evidence="ECO:0007829|PDB:7BAN"
FT TURN 1416..1419
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1420..1424
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1429..1432
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1436..1442
FT /evidence="ECO:0007829|PDB:7BAN"
FT TURN 1462..1464
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1469..1475
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1481..1486
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1488..1490
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1492..1497
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1499..1501
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1503..1507
FT /evidence="ECO:0007829|PDB:7BAN"
FT TURN 1515..1517
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1519..1521
FT /evidence="ECO:0007829|PDB:7BAN"
FT HELIX 1531..1533
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1539..1544
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1550..1554
FT /evidence="ECO:0007829|PDB:7BAN"
FT TURN 1555..1558
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1559..1564
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1572..1574
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1576..1580
FT /evidence="ECO:0007829|PDB:7BAN"
FT TURN 1581..1584
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1585..1589
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1595..1600
FT /evidence="ECO:0007829|PDB:7BAN"
FT TURN 1601..1603
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1606..1613
FT /evidence="ECO:0007829|PDB:7BAN"
FT TURN 1614..1616
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1617..1623
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1628..1633
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1635..1637
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1639..1643
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1649..1654
FT /evidence="ECO:0007829|PDB:7BAN"
FT HELIX 1656..1658
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1660..1664
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1669..1676
FT /evidence="ECO:0007829|PDB:7BAN"
FT TURN 1677..1680
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1681..1686
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1692..1697
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1703..1707
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1713..1729
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1736..1742
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1744..1753
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1756..1763
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1768..1771
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1777..1780
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1782..1784
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1793..1795
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1797..1801
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1803..1806
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1808..1819
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1821..1833
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1836..1844
FT /evidence="ECO:0007829|PDB:7BAN"
FT TURN 1845..1848
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1849..1854
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1860..1865
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1871..1877
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1883..1887
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1893..1898
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1901..1907
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1913..1918
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1923..1929
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1932..1936
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1942..1947
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1953..1957
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1959..1961
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1963..1970
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1972..1980
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1982..1985
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1988..1992
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 1998..2003
FT /evidence="ECO:0007829|PDB:7BAN"
FT TURN 2004..2007
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2008..2014
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2020..2024
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2029..2034
FT /evidence="ECO:0007829|PDB:7BAN"
FT TURN 2036..2038
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2041..2047
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2052..2060
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2063..2071
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2079..2085
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2087..2098
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2106..2110
FT /evidence="ECO:0007829|PDB:7BAN"
FT TURN 2112..2114
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2117..2120
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2123..2127
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2132..2135
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2137..2145
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2149..2158
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2161..2170
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2176..2186
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2190..2196
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2202..2209
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2211..2214
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2219..2221
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2223..2226
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2235..2239
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2245..2248
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2251..2255
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2261..2264
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2267..2271
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2277..2282
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2288..2293
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2299..2307
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2310..2313
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2317..2319
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2325..2328
FT /evidence="ECO:0007829|PDB:7BAN"
FT TURN 2329..2332
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2333..2339
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2345..2350
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2355..2360
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2366..2371
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2376..2382
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2388..2392
FT /evidence="ECO:0007829|PDB:7BAN"
FT HELIX 2402..2404
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2405..2408
FT /evidence="ECO:0007829|PDB:7BAN"
FT TURN 2409..2412
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2413..2415
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2417..2422
FT /evidence="ECO:0007829|PDB:7BAN"
FT TURN 2423..2426
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2427..2430
FT /evidence="ECO:0007829|PDB:7BAN"
FT HELIX 2435..2437
FT /evidence="ECO:0007829|PDB:7BAN"
FT HELIX 2453..2455
FT /evidence="ECO:0007829|PDB:7BAN"
FT HELIX 2466..2469
FT /evidence="ECO:0007829|PDB:7BAN"
FT HELIX 2472..2478
FT /evidence="ECO:0007829|PDB:7BAN"
FT HELIX 2482..2484
FT /evidence="ECO:0007829|PDB:7BAN"
FT HELIX 2501..2505
FT /evidence="ECO:0007829|PDB:7BAN"
FT HELIX 2507..2510
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2511..2514
FT /evidence="ECO:0007829|PDB:7BAN"
FT HELIX 2521..2532
FT /evidence="ECO:0007829|PDB:7BAN"
FT HELIX 2540..2542
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2570..2583
FT /evidence="ECO:0007829|PDB:7BAN"
FT HELIX 2589..2598
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2609..2611
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2614..2621
FT /evidence="ECO:0007829|PDB:7BAN"
FT HELIX 2626..2631
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2635..2640
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2646..2653
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2662..2670
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2673..2680
FT /evidence="ECO:0007829|PDB:7BAN"
FT HELIX 2683..2711
FT /evidence="ECO:0007829|PDB:7BAN"
FT HELIX 2722..2730
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2737..2743
FT /evidence="ECO:0007829|PDB:7BAN"
FT TURN 2745..2747
FT /evidence="ECO:0007829|PDB:7BAN"
FT HELIX 2749..2751
FT /evidence="ECO:0007829|PDB:7BAN"
FT HELIX 2755..2757
FT /evidence="ECO:0007829|PDB:7BAN"
FT STRAND 2758..2763
FT /evidence="ECO:0007829|PDB:7BAN"
SQ SEQUENCE 2769 AA; 307957 MW; 280D87D43FBE88A1 CRC64;
MDVKERKPYR SLTRRRDAER RYTSSSADSE EGKAPQKSYS SSETLKAYDQ DARLAYGSRV
KDIVPQEAEE FCRTGANFTL RELGLEEVTP PHGTLYRTDI GLPHCGYSMG AGSDADMEAD
TVLSPEHPVR LWGRSTRSGR SSCLSSRANS NLTLTDTEHE NTETDHPGGL QNHARLRTPP
PPLSHAHTPN QHHAASINSL NRGNFTPRSN PSPAPTDHSL SGEPPAGGAQ EPAHAQENWL
LNSNIPLETR NLGKQPFLGT LQDNLIEMDI LGASRHDGAY SDGHFLFKPG GTSPLFCTTS
PGYPLTSSTV YSPPPRPLPR STFARPAFNL KKPSKYCNWK CAALSAIVIS ATLVILLAYF
VAMHLFGLNW HLQPMEGQMY EITEDTASSW PVPTDVSLYP SGGTGLETPD RKGKGTTEGK
PSSFFPEDSF IDSGEIDVGR RASQKIPPGT FWRSQVFIDH PVHLKFNVSL GKAALVGIYG
RKGLPPSHTQ FDFVELLDGR RLLTQEARSL EGTPRQSRGT VPPSSHETGF IQYLDSGIWH
LAFYNDGKES EVVSFLTTAI ESVDNCPSNC YGNGDCISGT CHCFLGFLGP DCGRASCPVL
CSGNGQYMKG RCLCHSGWKG AECDVPTNQC IDVACSNHGT CITGTCICNP GYKGESCEEV
DCMDPTCSGR GVCVRGECHC SVGWGGTNCE TPRATCLDQC SGHGTFLPDT GLCSCDPSWT
GHDCSIEICA ADCGGHGVCV GGTCRCEDGW MGAACDQRAC HPRCAEHGTC RDGKCECSPG
WNGEHCTIAH YLDRVVKEGC PGLCNGNGRC TLDLNGWHCV CQLGWRGAGC DTSMETACGD
SKDNDGDGLV DCMDPDCCLQ PLCHINPLCL GSPNPLDIIQ ETQVPVSQQN LHSFYDRIKF
LVGRDSTHII PGENPFDGGH ACVIRGQVMT SDGTPLVGVN ISFVNNPLFG YTISRQDGSF
DLVTNGGISI ILRFERAPFI TQEHTLWLPW DRFFVMETII MRHEENEIPS CDLSNFARPN
PVVSPSPLTS FASSCAEKGP IVPEIQALQE EISISGCKMR LSYLSSRTPG YKSVLRISLT
HPTIPFNLMK VHLMVAVEGR LFRKWFAAAP DLSYYFIWDK TDVYNQKVFG LSEAFVSVGY
EYESCPDLIL WEKRTTVLQG YEIDASKLGG WSLDKHHALN IQSGILHKGN GENQFVSQQP
PVIGSIMGNG RRRSISCPSC NGLADGNKLL APVALTCGSD GSLYVGDFNY IRRIFPSGNV
TNILELRNKD FRHSHSPAHK YYLATDPMSG AVFLSDSNSR RVFKIKSTVV VKDLVKNSEV
VAGTGDQCLP FDDTRCGDGG KATEATLTNP RGITVDKFGL IYFVDGTMIR RIDQNGIIST
LLGSNDLTSA RPLSCDSVMD ISQVHLEWPT DLAINPMDNS LYVLDNNVVL QISENHQVRI
VAGRPMHCQV PGIDHFLLSK VAIHATLESA TALAVSHNGV LYIAETDEKK INRIRQVTTS
GEISLVAGAP SGCDCKNDAN CDCFSGDDGY AKDAKLNTPS SLAVCADGEL YVADLGNIRI
RFIRKNKPFL NTQNMYELSS PIDQELYLFD TTGKHLYTQS LPTGDYLYNF TYTGDGDITL
ITDNNGNMVN VRRDSTGMPL WLVVPDGQVY WVTMGTNSAL KSVTTQGHEL AMMTYHGNSG
LLATKSNENG WTTFYEYDSF GRLTNVTFPT GQVSSFRSDT DSSVHVQVET SSKDDVTITT
NLSASGAFYT LLQDQVRNSY YIGADGSLRL LLANGMEVAL QTEPHLLAGT VNPTVGKRNV
TLPIDNGLNL VEWRQRKEQA RGQVTVFGRR LRVHNRNLLS LDFDRVTRTE KIYDDHRKFT
LRILYDQAGR PSLWSPSSRL NGVNVTYSPG GYIAGIQRGI MSERMEYDQA GRITSRIFAD
GKTWSYTYLE KSMVLLLHSQ RQYIFEFDKN DRLSSVTMPN VARQTLETIR SVGYYRNIYQ
PPEGNASVIQ DFTEDGHLLH TFYLGTGRRV IYKYGKLSKL AETLYDTTKV SFTYDETAGM
LKTINLQNEG FTCTIRYRQI GPLIDRQIFR FTEEGMVNAR FDYNYDNSFR VTSMQAVINE
TPLPIDLYRY DDVSGKTEQF GKFGVIYYDI NQIITTAVMT HTKHFDAYGR MKEVQYEIFR
SLMYWMTVQY DNMGRVVKKE LKVGPYANTT RYSYEYDADG QLQTVSINDK PLWRYSYDLN
GNLHLLSPGN SARLTPLRYD IRDRITRLGD VQYKMDEDGF LRQRGGDIFE YNSAGLLIKA
YNRAGSWSVR YRYDGLGRRV SSKSSHSHHL QFFYADLTNP TKVTHLYNHS SSEITSLYYD
LQGHLFAMEL SSGDEFYIAC DNIGTPLAVF SGTGLMIKQI LYTAYGEIYM DTNPNFQIII
GYHGGLYDPL TKLVHMGRRD YDVLAGRWTS PDHELWKHLS SSNVMPFNLY MFKNNNPISN
SQDIKCFMTD VNSWLLTFGF QLHNVIPGYP KPDMDAMEPS YELIHTQMKT QEWDNSKSIL
GVQCEVQKQL KAFVTLERFD QLYGSTITSC QQAPKTKKFA SSGSVFGKGV KFALKDGRVT
TDIISVANED GRRVAAILNH AHYLENLHFT IDGVDTHYFV KPGPSEGDLA ILGLSGGRRT
LENGVNVTVS QINTVLNGRT RRYTDIQLQY GALCLNTRYG TTLDEEKARV LELARQRAVR
QAWAREQQRL REGEEGLRAW TEGEKQQVLS TGRVQGYDGF FVISVEQYPE LSDSANNIHF
MRQSEMGRR
