ID   BRAT1_AILME             Reviewed;         823 AA.
AC   D2I4M3;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   09-FEB-2010, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=BRCA1-associated ATM activator 1;
DE   AltName: Full=BRCA1-associated protein required for ATM activation protein 1;
GN   Name=BRAT1; Synonyms=BAAT1; ORFNames=PANDA_020555;
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX   NCBI_TaxID=9646;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA   Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA   Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA   Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA   Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA   Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA   Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA   Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA   Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA   Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA   Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA   Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA   Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA   Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA   Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
CC   -!- FUNCTION: Involved in DNA damage response; activates kinases ATM, SMC1A
CC       and PRKDC by modulating their phosphorylation status following ionizing
CC       radiation (IR) stress. Plays a role in regulating mitochondrial
CC       function and cell proliferation. Required for protein stability of MTOR
CC       and MTOR-related proteins, and cell cycle progress by growth factors.
CC       {ECO:0000250|UniProtKB:Q6PJG6}.
CC   -!- SUBUNIT: Interacts with BRCA1 and ATM. Interacts with MTOR, RPTOR,
CC       NDFIP1, SMC1A and PRKDC. {ECO:0000250|UniProtKB:Q6PJG6}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6PJG6}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q6PJG6}. Note=Present at double strand breaks
CC       (DSBs) following ionizing radiation treatment. The ubiquitinated form
CC       localizes in the nucleus in a NDFIP1-dependent manner.
CC       {ECO:0000250|UniProtKB:Q6PJG6}.
CC   -!- PTM: Ubiquitinated by NEDD4, NEDD4L and ITCH; mono- and
CC       polyubiquitinated forms are detected. {ECO:0000250|UniProtKB:Q6PJG6}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GL194507; EFB25217.1; -; Genomic_DNA.
DR   RefSeq; XP_011215184.1; XM_011216882.2.
DR   AlphaFoldDB; D2I4M3; -.
DR   STRING; 9646.ENSAMEP00000003393; -.
DR   Ensembl; ENSAMET00000003528; ENSAMEP00000003393; ENSAMEG00000003206.
DR   GeneID; 100464618; -.
DR   KEGG; aml:100464618; -.
DR   CTD; 221927; -.
DR   eggNOG; ENOG502QRW9; Eukaryota.
DR   GeneTree; ENSGT00390000017551; -.
DR   HOGENOM; CLU_018926_1_0_1; -.
DR   InParanoid; D2I4M3; -.
DR   OMA; DCGLWET; -.
DR   OrthoDB; 1337787at2759; -.
DR   TreeFam; TF324349; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0006915; P:apoptotic process; ISS:UniProtKB.
DR   GO; GO:0016477; P:cell migration; ISS:UniProtKB.
DR   GO; GO:0008283; P:cell population proliferation; ISS:UniProtKB.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR   GO; GO:0006006; P:glucose metabolic process; ISS:UniProtKB.
DR   GO; GO:0051646; P:mitochondrion localization; ISS:UniProtKB.
DR   GO; GO:0030307; P:positive regulation of cell growth; ISS:UniProtKB.
DR   GO; GO:0001934; P:positive regulation of protein phosphorylation; ISS:UniProtKB.
DR   GO; GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR038904; BRAT1.
DR   InterPro; IPR000357; HEAT.
DR   PANTHER; PTHR21331; PTHR21331; 1.
DR   Pfam; PF02985; HEAT; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW   Ubl conjugation.
FT   CHAIN           1..823
FT                   /note="BRCA1-associated ATM activator 1"
FT                   /id="PRO_0000395836"
FT   REPEAT          495..531
FT                   /note="HEAT 1"
FT   REPEAT          544..576
FT                   /note="HEAT 2"
FT   REGION          100..200
FT                   /note="Required for interaction with NDFIP1"
FT                   /evidence="ECO:0000250|UniProtKB:Q6PJG6"
FT   MOD_RES         744
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6PJG6"
SQ   SEQUENCE   823 AA;  88194 MW;  B73466087CE7002B CRC64;
     MDPECSQLLP ALCAVLADPR QPMADDTCLE KLLDWFKTIT EAGSSLLLLQ ENPCLVELLC
     HMLKPQDLSS RVLSFSLRLT GVFAAQEDCF QYLQQGELLP RLFGEAGPLG GAAWTAPTVR
     SGWIQGLRSL ARHPSALHFL ADCGAVDTIF SLQGDSSLFV ASAAGQLLVH ILGLSMQGPA
     DGPPSLQAGD WPACAQKIVD HIEESLRSAA TPQITQALNV LTTTFGHCHD PWTRVLWVRL
     SPLVAGLLEK DPVPAAHSLV DLLLSVARSP GLSSSSCGLW ETLAQTLSRL SPTQAGPLAL
     GILKLQDCPQ ALRAQAFAVL LQPLACVLKA TTQAPGASGM VDGTAGDSVT VDTLLPSKAA
     CVGLLCRTLA HLELLLPLPQ RPCPWPQASL LGAAVTLLQL CQGSASPTSD AGRHLCALLL
     GCVRVQRAAL DFLGTLSQGT GPPELVTEVF AVLLEYLRSP DSSPTVLKKA FQATFRWLLS
     SPKTPGCWDL DPQALLFLRE LLPVLQKRLC SPCWEVRDSG LEFLTQMTGR WGGQASFRHA
     LLASEVPKLT EQLLRDPESY VRASAVAATG QLSSQGLCVS PASPEHLGGQ QKSPLSELLH
     ILSTDSEGFP RRAAMHVFTQ WLRDSHADVV GDTEEFVAGV LQVASQDLDW EVRAQGLELA
     LVFLEQTLGQ PGSPCPYAVT PPVVAPARPL AQALQPLCRV RLFEFAFRAL FDCDRPVAQK
     SCDLLLFLRA KTASSSSPQE ARISPDVASV EAALQRWQAG DQAQPLGDLE PEVVLAVLRS
     MDLEGLRGAL AESSDHVEKS PQSLLQDMLA TVGILGENEA DCY