ID   TENP_CHICK              Reviewed;         440 AA.
AC   O42273;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Protein TENP;
GN   Name=TENP;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAC14583.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], PUTATIVE FUNCTION, TISSUE SPECIFICITY, AND
RP   DEVELOPMENTAL STAGE.
RC   STRAIN=White leghorn {ECO:0000312|EMBL:AAC14583.1};
RC   TISSUE=Embryonic brain {ECO:0000269|PubMed:9514522};
RX   PubMed=9514522;
RX   DOI=10.1002/(sici)1097-4695(199803)34:4<319::aid-neu3>3.0.co;2-9;
RA   Yan R.-T., Wang S.-Z.;
RT   "Identification and characterization of tenp, a gene transiently expressed
RT   before overt cell differentiation during neurogenesis.";
RL   J. Neurobiol. 34:319-328(1998).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-16; 15-45; 71-87; 86-95; 94-107; 280-302; 305-313;
RP   353-378 AND 377-403, TISSUE SPECIFICITY, INDUCTION, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RC   TISSUE=Egg white {ECO:0000303|PubMed:25436390};
RX   PubMed=25436390; DOI=10.1021/jf504469t;
RA   Kim J., Choi Y.H.;
RT   "Differential abundance of egg white proteins in laying hens treated with
RT   corticosterone.";
RL   J. Agric. Food Chem. 62:12346-12359(2014).
CC   -!- FUNCTION: May play a role in the developmental transition from cell
CC       proliferation to cell differentiation during neurogenesis.
CC       {ECO:0000269|PubMed:9514522}.
CC   -!- TISSUE SPECIFICITY: Expressed in developing retina and brain, but not
CC       in heart, liver or kidney. In brain, located in a narrow strip in the
CC       boundary between the ventricular zone (consisting of proliferating
CC       cells) and the intermediate zone (consisting of postmitotic,
CC       differentiating cells). Expressed in all major regions of the
CC       developing brain, including the myelencephalon, the mesencephalon, the
CC       telencephalon and the diencephalon. In the developing retina,
CC       expression is scattered across the retinal neural epithelium
CC       (PubMed:9514522). Expressed in egg white (at protein level). Expressed
CC       in the magnum of the oviduct (at protein level) (PubMed:25436390).
CC       {ECO:0000269|PubMed:25436390, ECO:0000269|PubMed:9514522}.
CC   -!- DEVELOPMENTAL STAGE: In brain, not abundant during the early stages of
CC       neurogenesis. Expression increases during cytogenesis followed by a
CC       rapid decrease towards the end of cytogenesis. Undetectable at E16. In
CC       retina, expression is detected at E4 and E6, and becomes scarce by E8.
CC       Not detected in the mature retina. {ECO:0000269|PubMed:9514522}.
CC   -!- INDUCTION: Down-regulated by dietary stress. Significantly decreased
CC       expression between days 0 to 5 in egg whites of eggs laid by
CC       corticosterone-fed hens (at protein level). Decreased expression at day
CC       14 in the magnum of the oviduct in the corticosterone-fed laying hens.
CC       {ECO:0000269|PubMed:25436390}.
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DR   EMBL; AF029841; AAC14583.1; -; mRNA.
DR   RefSeq; NP_990357.1; NM_205026.1.
DR   AlphaFoldDB; O42273; -.
DR   SMR; O42273; -.
DR   STRING; 9031.ENSGALP00000038462; -.
DR   PRIDE; O42273; -.
DR   GeneID; 395882; -.
DR   KEGG; gga:395882; -.
DR   CTD; 80341; -.
DR   VEuPathDB; HostDB:geneid_395882; -.
DR   eggNOG; KOG4160; Eukaryota.
DR   InParanoid; O42273; -.
DR   PhylomeDB; O42273; -.
DR   PRO; PR:O42273; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0016020; C:membrane; IDA:AgBase.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   GO; GO:0051412; P:response to corticosterone; IDA:AgBase.
DR   InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR   InterPro; IPR001124; Lipid-bd_serum_glycop_C.
DR   Pfam; PF02886; LBP_BPI_CETP_C; 1.
DR   SMART; SM00329; BPI2; 1.
DR   SUPFAM; SSF55394; SSF55394; 1.
PE   1: Evidence at protein level;
KW   Developmental protein; Direct protein sequencing; Reference proteome.
FT   CHAIN           1..440
FT                   /note="Protein TENP"
FT                   /id="PRO_0000389230"
FT   CONFLICT        80
FT                   /note="I -> V (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        95
FT                   /note="I -> V (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        100
FT                   /note="T -> A (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   440 AA;  47435 MW;  A46C2D7FF34F2686 CRC64;
     MGALLALLDP VQPTRAPDCG GILTPLGLSY LAEVSKPHAE VVLRQDLMPK EPQTCSLAPW
     SPAGTELPAV KVADLWLSVI PEAGLRLGIE VELRIAPLHT VPMPVRISIR ADLHVDMGPD
     GNLQLLTSAC RPTVQAQSTR EAESKSSRSI LDKVVDVDKL CLDVSKLLLF PNEQLMSLTA
     LFPVTPNCQL QYLALAAPVF SKQGIALSLQ TTFQVAGAVV PVPVSPVPFS MPELASTSTS
     HLILALSEHF YTSLYFTLER AGAFNMTIPS MLTTATLAQK ITQVGSLYHE DLPITLSAAL
     RSSPRVVLEE GRAALKLFLT VHIGAGSPDF QSFLSVSADV TRAGLQLSVS DTRMMISTAV
     IEDAELSLAA SNVGLVRAAL LEELFLAPVC QQVPAWMDDV LREGVHLPHM SHFTYTDVNV
     VVHKDYVLVP CKLKLRSTMA