ID   TENR_BEAB2              Reviewed;         875 AA.
AC   J4VZG1;
DT   25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2012, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Transcription factor tenR {ECO:0000303|PubMed:34903054};
DE   AltName: Full=Tenellin-type 2-pyridones biosynthesis cluster regulator {ECO:0000303|PubMed:34903054};
GN   Name=tenR {ECO:0000303|PubMed:34903054}; ORFNames=BBA_07334;
OS   Beauveria bassiana (strain ARSEF 2860) (White muscardine disease fungus)
OS   (Tritirachium shiotae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Cordycipitaceae; Beauveria.
OX   NCBI_TaxID=655819;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ARSEF 2860;
RX   PubMed=22761991; DOI=10.1038/srep00483;
RA   Xiao G., Ying S.-H., Zheng P., Wang Z.-L., Zhang S., Xie X.-Q., Shang Y.,
RA   St Leger R.J., Zhao G.-P., Wang C., Feng M.-G.;
RT   "Genomic perspectives on the evolution of fungal entomopathogenicity in
RT   Beauveria bassiana.";
RL   Sci. Rep. 2:483-483(2012).
RN   [2]
RP   FUNCTION.
RX   PubMed=34903054; DOI=10.1128/mbio.03279-21;
RA   Chen B., Sun Y., Li S., Yin Y., Wang C.;
RT   "Inductive production of the iron-chelating 2-pyridones benefits the
RT   producing fungus to compete for diverse niches.";
RL   MBio 12:e0327921-e0327921(2021).
CC   -!- FUNCTION: Transcription factor that posively regulates the expression
CC       of the genes that mediate the biosynthesis of tenellin-type 2-
CC       pyridones, iron-chelating compounds involved in iron stress tolerance,
CC       competition with the natural competitor fungus Metarhizium robertsii
CC       and insect hosts infection. {ECO:0000269|PubMed:34903054}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR   EMBL; JH725173; EJP63690.1; -; Genomic_DNA.
DR   RefSeq; XP_008600653.1; XM_008602431.1.
DR   EnsemblFungi; EJP63690; EJP63690; BBA_07334.
DR   GeneID; 19890346; -.
DR   HOGENOM; CLU_007091_4_0_1; -.
DR   InParanoid; J4VZG1; -.
DR   Proteomes; UP000002762; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..875
FT                   /note="Transcription factor tenR"
FT                   /id="PRO_0000455685"
FT   DNA_BIND        16..44
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          54..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          136..172
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          620..642
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        147..170
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        626..642
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   875 AA;  96693 MW;  908471E517DC61F6 CRC64;
     MEPGPAHRRR RPAVACSECR RRKIRCDRGF PCGPCRKSLP ALSCIYHSQP RAYAASAPPR
     PHTAQHQPRP KVNNTHSVDL TKFNLPSFES DAFHGLDQFG IDWQPSWEHQ ITPPTGHLAD
     AGADYFQSPT FSVIDDHEKK ESTNHSRARQ GYPGSTETIN PGSVSHSAGV NPDSGDDRWY
     QILARIGKVE YLIRDITRHQ SSDEAQLVPI LRDLYEAEPD ECLRLPPLSG IVLKLENQAR
     LQKQQDDKQS LARLSPLLDA SSKIHQLLPP RQACKKLVSA YFETFGSVLC ILDTAVFTSE
     FERFWEAIDA SRVPSTDHEE AFAHKLLVVI ALGSVTCPSS PGAASSEAER ARQTSRRNHA
     IMCVQHTRQW LAQKTARGIR ADLDVAQILC LLALARQTQL HTDPWPRRPS MDGTVILTGD
     HDLARLGMQM GLHREPRTGS MAKPAKEAET ELRRRLWATM LELSLHQYLD AELPPPLGAD
     SYDCATPSSN GVEEEPRSYF VPDSLRVPAS TVLAALSRTQ RLRLRVLEHL HASGASKDIQ
     ESQRLAIELS QAFNSEVNSL LSPASTQPTS FQLWLLNVFV RPFILALGVP LSGESRNRFA
     DYYLRRLRLE NAVAMLRPGP HEDGPRSIQS QISSHAGQTG SRTKTAATAY PFLPTPGTAE
     PCNTSSEQHF GTHKAACTSL YIGGPSYYAV VHRQVVASLC ADVVAEIEDD MFPNLDAAML
     HRIVAILEDA VNEYRDQVHA SAGAHACHEF ILFAAAHSLA LASLNRSSAR EVKESVMSSV
     WMALHHCCQA MGEPAEAMLE TEWGTEAVQQ TATESQSVNR SVSDADKGYE IDAQLQGVKY
     MLQQQSDAAS TADGEIADMW AFDDDESYLS VGLPL