ID   BRAT1_DANRE             Reviewed;         822 AA.
AC   Q1RLU1;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=BRCA1-associated ATM activator 1;
DE   AltName: Full=BRCA1-associated protein required for ATM activation protein 1;
GN   Name=brat1; Synonyms=baat1; ORFNames=zgc:136845;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in DNA damage response; activates kinases ATM, SMC1A
CC       and PRKDC by modulating their phosphorylation status following ionizing
CC       radiation (IR) stress. {ECO:0000250|UniProtKB:Q6PJG6}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6PJG6}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q6PJG6}. Note=Present at double strand breaks
CC       (DSBs) following ionizing radiation treatment.
CC       {ECO:0000250|UniProtKB:Q6PJG6}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC115289; AAI15290.1; -; mRNA.
DR   RefSeq; NP_001035395.1; NM_001040305.1.
DR   AlphaFoldDB; Q1RLU1; -.
DR   STRING; 7955.ENSDARP00000085122; -.
DR   PaxDb; Q1RLU1; -.
DR   Ensembl; ENSDART00000090689; ENSDARP00000085122; ENSDARG00000062585.
DR   GeneID; 678547; -.
DR   KEGG; dre:678547; -.
DR   CTD; 221927; -.
DR   ZFIN; ZDB-GENE-060421-6989; brat1.
DR   eggNOG; ENOG502QRW9; Eukaryota.
DR   GeneTree; ENSGT00390000017551; -.
DR   HOGENOM; CLU_018926_1_0_1; -.
DR   InParanoid; Q1RLU1; -.
DR   OMA; DCGLWET; -.
DR   OrthoDB; 1337787at2759; -.
DR   PhylomeDB; Q1RLU1; -.
DR   TreeFam; TF324349; -.
DR   PRO; PR:Q1RLU1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 1.
DR   Bgee; ENSDARG00000062585; Expressed in mature ovarian follicle and 20 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0008283; P:cell population proliferation; IEA:InterPro.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR   GO; GO:0001934; P:positive regulation of protein phosphorylation; ISS:UniProtKB.
DR   GO; GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR038904; BRAT1.
DR   PANTHER; PTHR21331; PTHR21331; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; DNA damage; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..822
FT                   /note="BRCA1-associated ATM activator 1"
FT                   /id="PRO_0000360152"
FT   REPEAT          490..528
FT                   /note="HEAT 1"
FT   REPEAT          535..573
FT                   /note="HEAT 2"
SQ   SEQUENCE   822 AA;  90626 MW;  6C8D4B24B75130AB CRC64;
     MDGDCSSLLP AVCLVLADPK QTPPDDTSLE KLLDWFKDLH SQSNGQVLLE HQPCLLEFIS
     SVCASKATDP AILSFTLKLT GLLAASKQDF HLLEEGGHLV CVFEREAWSV CDLWEDASVR
     SGWIQGLLNM LKHQQALDFI CRQGLIKVIL QLQNDRSLFV ACLANQLLVQ ILKLLTPSDV
     TSGSDAVVSS KSSSSLDWVS VSSEITNAVV EALSSENHPQ VLQGVQLLSL VLSQCEEPIR
     SSLWKDVLPP LEVLINRGSE PLTQPLMTVL RAAVMTPLLG QSEYKVEEFL EVMLGTGNRK
     EGILCATLIV KLEKCPKVLK RKAMDIILLP LQCVSTQSQD EKEVDLVLKE PLSQKALCIS
     LLVQSLSSLA ELAHKEYFEG VCIPSVTSRV VQLLRVCSGH CTSSLLHVSA CTHLIGSCKI
     QRCGLDTLGA LSVYEDNLDL RKDIFGVLLD YLKSPDSHAT VLKKTFQAVL RWIGVCASFP
     DLLQFISNDL FPVLEKRMCD VRWEVRDSTL EFITQLTVAL SDNSGFVEVL YTSGLVSILL
     SLLSDTEGYV RASAVTAVGE AVTSSVQQMA LVSKINLLEE ALAQMMIILS QDTEGFPRRA
     VVKTFTSWLK GSNPITALDS SLSSVLSLGG NDFDWEVKMH TLELAEALME KMLTCCPYAV
     QSFSSSERTR LTQSLSKLKD LGLFDVLLNG LFDCDRPVCE KSCQLLLKLK RLNAEKADFD
     HDALVLKACG NRWGDEVQSR FLNKQQVKAS EHVLIGGGEG TEKDLHCIKE IPLSVILQIL
     DLDDMQRMLK LSSDHVVNSP RSLMEDILSA AQQSEENIVD CY