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TENS4_MOUSE
ID   TENS4_MOUSE             Reviewed;         696 AA.
AC   Q8BZ33; A2A552; Q3TCM8; Q7TNR5;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 2.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=Tensin-4;
DE   Flags: Precursor;
GN   Name=Tns4;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and NOD; TISSUE=Vagina;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in cell migration, cartilage development and
CC       in linking signal transduction pathways to the cytoskeleton. May
CC       promote apoptosis, via its cleavage by caspase-3. Cytoplasm,
CC       cytoskeleton. {ECO:0000250}.
CC   -!- SUBUNIT: Binds to actin filaments and interacts with phosphotyrosine-
CC       containing proteins. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000250}.
CC       Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- PTM: Proteolytically cleaved by caspase-3 during apoptosis.
CC       {ECO:0000250}.
CC   -!- PTM: Tyrosine phosphorylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PTEN phosphatase protein family.
CC       {ECO:0000305}.
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DR   EMBL; AL591366; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH466556; EDL16179.1; -; Genomic_DNA.
DR   EMBL; AK036834; BAC29598.1; -; mRNA.
DR   EMBL; AK170638; BAE41928.1; -; mRNA.
DR   EMBL; BC055820; AAH55820.1; -; mRNA.
DR   CCDS; CCDS25372.1; -.
DR   RefSeq; NP_766152.2; NM_172564.3.
DR   AlphaFoldDB; Q8BZ33; -.
DR   SMR; Q8BZ33; -.
DR   STRING; 10090.ENSMUSP00000017751; -.
DR   iPTMnet; Q8BZ33; -.
DR   PhosphoSitePlus; Q8BZ33; -.
DR   MaxQB; Q8BZ33; -.
DR   PaxDb; Q8BZ33; -.
DR   PeptideAtlas; Q8BZ33; -.
DR   PRIDE; Q8BZ33; -.
DR   ProteomicsDB; 263277; -.
DR   Antibodypedia; 16494; 218 antibodies from 27 providers.
DR   DNASU; 217169; -.
DR   Ensembl; ENSMUST00000017751; ENSMUSP00000017751; ENSMUSG00000017607.
DR   GeneID; 217169; -.
DR   KEGG; mmu:217169; -.
DR   UCSC; uc007lig.2; mouse.
DR   CTD; 84951; -.
DR   MGI; MGI:2144377; Tns4.
DR   VEuPathDB; HostDB:ENSMUSG00000017607; -.
DR   eggNOG; KOG1930; Eukaryota.
DR   GeneTree; ENSGT00940000160142; -.
DR   HOGENOM; CLU_398985_0_0_1; -.
DR   InParanoid; Q8BZ33; -.
DR   OMA; SQPSMKF; -.
DR   OrthoDB; 172407at2759; -.
DR   PhylomeDB; Q8BZ33; -.
DR   TreeFam; TF315996; -.
DR   Reactome; R-MMU-8875513; MET interacts with TNS proteins.
DR   BioGRID-ORCS; 217169; 2 hits in 73 CRISPR screens.
DR   ChiTaRS; Tns4; mouse.
DR   PRO; PR:Q8BZ33; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q8BZ33; protein.
DR   Bgee; ENSMUSG00000017607; Expressed in left colon and 57 other tissues.
DR   Genevisible; Q8BZ33; MM.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005925; C:focal adhesion; ISO:MGI.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0008104; P:protein localization; ISO:MGI.
DR   CDD; cd01213; PTB_tensin; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR013625; PTB.
DR   InterPro; IPR006020; PTB/PI_dom.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR033929; Tensin_PTB.
DR   Pfam; PF08416; PTB; 1.
DR   Pfam; PF00017; SH2; 1.
DR   SMART; SM00462; PTB; 1.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Apoptosis; Cell junction; Cytoplasm; Cytoskeleton;
KW   Phosphoprotein; Reference proteome; SH2 domain; Signal.
FT   SIGNAL          1..14
FT                   /evidence="ECO:0000250"
FT   CHAIN           15..696
FT                   /note="Tensin-4"
FT                   /id="PRO_0000248214"
FT   DOMAIN          429..536
FT                   /note="SH2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT   DOMAIN          528..695
FT                   /note="Phosphatase tensin-type"
FT   REGION          157..246
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          271..344
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          356..416
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        186..232
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        271..303
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        309..344
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        369..393
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         230
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IZW8"
FT   CONFLICT        268
FT                   /note="S -> I (in Ref. 3; BAC29598)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        490
FT                   /note="H -> D (in Ref. 3; BAE41928)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        507
FT                   /note="E -> K (in Ref. 3; BAE41928)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        589
FT                   /note="T -> I (in Ref. 4; AAH55820)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   696 AA;  74622 MW;  E2EB3F1D4DBFD079 CRC64;
     MSSSLLAGGH MVSLTPCEES RMALHPTPSP GLPALCPYYT TESWGTQPLM APTLRKGSSD
     RLQQAQQAEA RAHCLLQGPG EQASGASQDL ESCIDFSLEA LNQMILEIDP TFQLLPSGTA
     GPQAESTNSI MSRNKKEEPE ALDIKYIEVT STRSRYLDGP QRCSSPCATP PFGSPRSGSL
     FLSRDIPRET RSSSNESLIF SGNQGRGPSP LTPSSLSNAI PCRESRTSGS PLATPPGWEK
     GLRAPQRGSR VSILSASPVS DVSYVFGSNQ SLPHSSLSSY PSSSRSLGSP ASSSSSLHSL
     DRGSQCGRPS DAQAPSNPIL GMGQPQAVQS TPVAKEQASS CPASVTNSMA DIPIVLINGS
     PEPQSPPAQR TPGHQDSVQS RVTSPSHLCQ AIKSPSKTLP DVPLPASPDG PAKDMQPTMK
     FVMDTSKYWF KPSITREQAI NLLRTEKPGA FVIRDSSSYR GSFGLALKVQ ETSASAPNRP
     GEDSSDLIRH FLIESSAKGV HLKGADEEPY FGSLSSFVCQ HSIMALALPC KLTIPQKELG
     GAEPASDSPT HGQTSCLKIS AGCHTLYLSS VSVETLSGAL AVQKAISVTL ERDVLPTPTV
     VHFKVTEQGI TLTDVQRKVF FRRHYPLSAL RFCGMDPEQR KWQKYCKPSR IFGFVAKSQT
     EPQENVCHLF AEYDAVQPAS QVISLVTALL QDTERM
 
 
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