TEPA_ALKHC
ID TEPA_ALKHC Reviewed; 256 AA.
AC Q9KA93;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Translocation-enhancing protein TepA;
GN Name=tepA; OrderedLocusNames=BH2397;
OS Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS / JCM 9153 / C-125) (Bacillus halodurans).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX NCBI_TaxID=272558;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT and genomic sequence comparison with Bacillus subtilis.";
RL Nucleic Acids Res. 28:4317-4331(2000).
CC -!- FUNCTION: This activity is required for efficient translocation of pre-
CC proteins across the membrane. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the peptidase S14 family. TepA subfamily.
CC {ECO:0000305}.
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DR EMBL; BA000004; BAB06116.1; -; Genomic_DNA.
DR PIR; E83949; E83949.
DR RefSeq; WP_010898550.1; NC_002570.2.
DR AlphaFoldDB; Q9KA93; -.
DR SMR; Q9KA93; -.
DR STRING; 272558.10175017; -.
DR MEROPS; S14.012; -.
DR DNASU; 892344; -.
DR EnsemblBacteria; BAB06116; BAB06116; BAB06116.
DR KEGG; bha:BH2397; -.
DR eggNOG; COG0740; Bacteria.
DR HOGENOM; CLU_066827_1_0_9; -.
DR OMA; KMQDRVI; -.
DR OrthoDB; 1399458at2; -.
DR Proteomes; UP000001258; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR023562; ClpP/TepA.
DR Pfam; PF00574; CLP_protease; 1.
DR SUPFAM; SSF52096; SSF52096; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Hydrolase; Protease; Protein transport; Reference proteome;
KW Translocation; Transport.
FT CHAIN 1..256
FT /note="Translocation-enhancing protein TepA"
FT /id="PRO_0000179763"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 133
FT /note="Nucleophile"
FT /evidence="ECO:0000250"
FT ACT_SITE 156
FT /evidence="ECO:0000250"
SQ SEQUENCE 256 AA; 28027 MW; 99A1F4C8227F4096 CRC64;
MDYGRQDEQP EQPQQPEQPQ QEPSQEGKPS GIIEKIQQLG QTNVPEMEQS NIHCITVVGQ
IEGHMQLPPQ NKTTKYEHII PQLVAAEQNK KIEGLLIILN TVGGDVEAGL AIAEMVATMS
KPTVTLVLGG GHSIGVPIAV AANYSFIAET ATMTIHPVRL TGLVIGVPQT FEYLDKMQER
VVSFVTKHSH ISEEKFKELM FSKGNLTRDI GTNVIGTDAV TYGLIDEVGG IGKAMQKLTE
LIEKQQPPHP EGEMMQ