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TEPA_ALKHC
ID   TEPA_ALKHC              Reviewed;         256 AA.
AC   Q9KA93;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Translocation-enhancing protein TepA;
GN   Name=tepA; OrderedLocusNames=BH2397;
OS   Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS   / JCM 9153 / C-125) (Bacillus halodurans).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX   NCBI_TaxID=272558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX   PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA   Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA   Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT   "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT   and genomic sequence comparison with Bacillus subtilis.";
RL   Nucleic Acids Res. 28:4317-4331(2000).
CC   -!- FUNCTION: This activity is required for efficient translocation of pre-
CC       proteins across the membrane. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase S14 family. TepA subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BA000004; BAB06116.1; -; Genomic_DNA.
DR   PIR; E83949; E83949.
DR   RefSeq; WP_010898550.1; NC_002570.2.
DR   AlphaFoldDB; Q9KA93; -.
DR   SMR; Q9KA93; -.
DR   STRING; 272558.10175017; -.
DR   MEROPS; S14.012; -.
DR   DNASU; 892344; -.
DR   EnsemblBacteria; BAB06116; BAB06116; BAB06116.
DR   KEGG; bha:BH2397; -.
DR   eggNOG; COG0740; Bacteria.
DR   HOGENOM; CLU_066827_1_0_9; -.
DR   OMA; KMQDRVI; -.
DR   OrthoDB; 1399458at2; -.
DR   Proteomes; UP000001258; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR023562; ClpP/TepA.
DR   Pfam; PF00574; CLP_protease; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase; Protease; Protein transport; Reference proteome;
KW   Translocation; Transport.
FT   CHAIN           1..256
FT                   /note="Translocation-enhancing protein TepA"
FT                   /id="PRO_0000179763"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..27
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        133
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        156
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   256 AA;  28027 MW;  99A1F4C8227F4096 CRC64;
     MDYGRQDEQP EQPQQPEQPQ QEPSQEGKPS GIIEKIQQLG QTNVPEMEQS NIHCITVVGQ
     IEGHMQLPPQ NKTTKYEHII PQLVAAEQNK KIEGLLIILN TVGGDVEAGL AIAEMVATMS
     KPTVTLVLGG GHSIGVPIAV AANYSFIAET ATMTIHPVRL TGLVIGVPQT FEYLDKMQER
     VVSFVTKHSH ISEEKFKELM FSKGNLTRDI GTNVIGTDAV TYGLIDEVGG IGKAMQKLTE
     LIEKQQPPHP EGEMMQ
 
 
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