TEPP_HUMAN
ID TEPP_HUMAN Reviewed; 271 AA.
AC Q6URK8; Q6URK7;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 3.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Testis, prostate and placenta-expressed protein;
DE Flags: Precursor;
GN Name=TEPP;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND TISSUE SPECIFICITY.
RC TISSUE=Prostate;
RX PubMed=14652002; DOI=10.1016/j.bbrc.2003.11.031;
RA Bera T.K., Hahn Y., Lee B., Pastan I.H.;
RT "TEPP, a new gene specifically expressed in testis, prostate, and placenta
RT and well conserved in chordates.";
RL Biochem. Biophys. Res. Commun. 312:1209-1215(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6URK8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6URK8-2; Sequence=VSP_032403;
CC -!- TISSUE SPECIFICITY: Expressed in testis, prostate and placenta.
CC {ECO:0000269|PubMed:14652002}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY363222; AAR18688.1; -; mRNA.
DR EMBL; AY363223; AAR18689.1; -; mRNA.
DR EMBL; AC010543; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC104458; AAI04459.1; -; mRNA.
DR EMBL; BC104459; AAI04460.1; -; mRNA.
DR RefSeq; NP_950247.2; NM_199046.2.
DR RefSeq; NP_955535.2; NM_199456.2.
DR AlphaFoldDB; Q6URK8; -.
DR BioGRID; 131919; 5.
DR IntAct; Q6URK8; 1.
DR STRING; 9606.ENSP00000290871; -.
DR iPTMnet; Q6URK8; -.
DR PhosphoSitePlus; Q6URK8; -.
DR BioMuta; TEPP; -.
DR DMDM; 308153544; -.
DR MassIVE; Q6URK8; -.
DR PeptideAtlas; Q6URK8; -.
DR PRIDE; Q6URK8; -.
DR ProteomicsDB; 67422; -. [Q6URK8-1]
DR ProteomicsDB; 67423; -. [Q6URK8-2]
DR TopDownProteomics; Q6URK8-2; -. [Q6URK8-2]
DR Antibodypedia; 62568; 4 antibodies from 4 providers.
DR DNASU; 374739; -.
DR Ensembl; ENST00000290871.10; ENSP00000290871.6; ENSG00000159648.13.
DR Ensembl; ENST00000441824.4; ENSP00000401917.3; ENSG00000159648.13.
DR GeneID; 374739; -.
DR KEGG; hsa:374739; -.
DR UCSC; uc002emv.5; human. [Q6URK8-1]
DR CTD; 374739; -.
DR DisGeNET; 374739; -.
DR GeneCards; TEPP; -.
DR HGNC; HGNC:33745; TEPP.
DR HPA; ENSG00000159648; Tissue enriched (testis).
DR MIM; 610264; gene.
DR neXtProt; NX_Q6URK8; -.
DR PharmGKB; PA165450719; -.
DR VEuPathDB; HostDB:ENSG00000159648; -.
DR eggNOG; ENOG502R4EY; Eukaryota.
DR HOGENOM; CLU_081890_0_0_1; -.
DR InParanoid; Q6URK8; -.
DR OMA; PPQYCLN; -.
DR OrthoDB; 1113022at2759; -.
DR PhylomeDB; Q6URK8; -.
DR TreeFam; TF329060; -.
DR PathwayCommons; Q6URK8; -.
DR SignaLink; Q6URK8; -.
DR BioGRID-ORCS; 374739; 9 hits in 1064 CRISPR screens.
DR GenomeRNAi; 374739; -.
DR Pharos; Q6URK8; Tdark.
DR PRO; PR:Q6URK8; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q6URK8; protein.
DR Bgee; ENSG00000159648; Expressed in left testis and 96 other tissues.
DR Genevisible; Q6URK8; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR034584; TEPP.
DR PANTHER; PTHR35348; PTHR35348; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..271
FT /note="Testis, prostate and placenta-expressed protein"
FT /id="PRO_0000325777"
FT VAR_SEQ 229
FT /note="R -> RQEALCGAWAGRPCSPDSPRPYPCCPPQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14652002"
FT /id="VSP_032403"
FT VARIANT 260
FT /note="S -> N (in dbSNP:rs9934227)"
FT /id="VAR_060223"
FT CONFLICT 233
FT /note="S -> N (in Ref. 1; AAR18688/AAR18689 and 3;
FT AAI04459/AAI04460)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 271 AA; 30717 MW; 711408BF21E4B05D CRC64;
MGIVCAQCSF ILLLSIIRAR PPPFLFCPLS SQRTESPYKP VHLGLGPTDK VAAIAMARII
DLVPWDDGST HVYASPAILL PMERQRNQLA GVKQQLYHPA LPTLRHMDRD TVKACLPDEH
CQSTTYCRKD EFDNAHFTLL GVPNKPLQCL DITATGQKLR NRYHEGKLAP IAPGINRVDW
PCFTRAIEDW SHFVSSAGEF KLPCLRKRAE GLSGYAVRYL KPDVTQTWRY CLSQNPSLDR
YGQKPLPFDS LNTFRSFGSS YSRVNYLTPW H
