BRAZ_PSEAE
ID BRAZ_PSEAE Reviewed; 437 AA.
AC P25185;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1992, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Branched-chain amino acid transport system 3 carrier protein;
DE AltName: Full=LIV-III;
GN Name=braZ; OrderedLocusNames=PA1971;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=PAO;
RX PubMed=1900503; DOI=10.1128/jb.173.6.1855-1861.1991;
RA Hoshino T., Kose-Terai K., Uratani Y.;
RT "Isolation of the braZ gene encoding the carrier for a novel branched-chain
RT amino acid transport system in Pseudomonas aeruginosa PAO.";
RL J. Bacteriol. 173:1855-1861(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: Component of the LIV-III transport system for branched-chain
CC amino acids. BraZ is specific for isoleucine and valine. The LIV-III
CC transport system may be H(+)-coupled.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the branched chain amino acid transporter
CC family. {ECO:0000305}.
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DR EMBL; D90222; BAA14253.1; -; Genomic_DNA.
DR EMBL; AE004091; AAG05359.1; -; Genomic_DNA.
DR PIR; A38534; A38534.
DR RefSeq; NP_250661.1; NC_002516.2.
DR RefSeq; WP_003113469.1; NZ_QZGE01000030.1.
DR AlphaFoldDB; P25185; -.
DR STRING; 287.DR97_5877; -.
DR TCDB; 2.A.26.1.2; the branched chain amino acid:cation symporter (livcs) family.
DR PaxDb; P25185; -.
DR EnsemblBacteria; AAG05359; AAG05359; PA1971.
DR GeneID; 879216; -.
DR KEGG; pae:PA1971; -.
DR PATRIC; fig|208964.12.peg.2054; -.
DR PseudoCAP; PA1971; -.
DR HOGENOM; CLU_036807_0_0_6; -.
DR InParanoid; P25185; -.
DR OMA; IWPAGPI; -.
DR PhylomeDB; P25185; -.
DR BioCyc; PAER208964:G1FZ6-2009-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015188; F:L-isoleucine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015190; F:L-leucine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005304; F:L-valine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015803; P:branched-chain amino acid transport; IDA:PseudoCAP.
DR GO; GO:0015818; P:isoleucine transport; IBA:GO_Central.
DR GO; GO:0015820; P:leucine transport; IBA:GO_Central.
DR GO; GO:0015829; P:valine transport; IBA:GO_Central.
DR InterPro; IPR004685; Brnchd-chn_aa_trnsp_Livcs.
DR PANTHER; PTHR30588; PTHR30588; 1.
DR Pfam; PF05525; Branch_AA_trans; 1.
DR TIGRFAMs; TIGR00796; livcs; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..437
FT /note="Branched-chain amino acid transport system 3 carrier
FT protein"
FT /id="PRO_0000099774"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 316..336
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 342..362
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 369..389
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 399..419
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 437 AA; 45274 MW; 5A0B5B5A55E09226 CRC64;
MNALKGRDIL ALGFMTFALF VGAGNIIFPP IVGLQSGPHV WLAALGFLIT AVGLPVITVI
ALAKVGGSVD ALSHPIGRYA GGLLAAVCYL AVGPLFAIPR TATVSFEVGV VPLLGESGTA
LFVYSLAYFL LALAISLYPG RLLDTVGRFL APLKILALAI LGVAAFLWPA GPIGTAQPEY
TQAAFSQGFV NGYLTMDTLA ALVFGIVIVN AIRSRGVQSP RLITRYAIVA GLIAGVGLVL
VYVSLFRLGA GSHAIAADAS NGAAVLHAYV QHTFGSLGSS FLAGLIALAC LVTAVGLTCA
CAEYFCQRLP LSYRSLVIIL AGFSFIVSNL GLTKLIQVSI PVLTAIYPPC IVLVALSFCI
GLWHSATRIL APVMLVSLAF GVLDALKAAG LGQDFPQWLL HLPLAEQGLA WLIPSVATLA
ACSLVDRLLG KPAQVAA
