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TERB2_BOVIN
ID   TERB2_BOVIN             Reviewed;         221 AA.
AC   Q2M2T9;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Telomere repeats-binding bouquet formation protein 2 {ECO:0000250|UniProtKB:Q9D494};
GN   Name=TERB2 {ECO:0000250|UniProtKB:Q9D494};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Meiosis-specific telomere-associated protein involved in
CC       meiotic telomere attachment to the nucleus inner membrane, a crucial
CC       step for homologous pairing and synapsis. Component of the MAJIN-TERB1-
CC       TERB2 complex, which promotes telomere cap exchange by mediating
CC       attachment of telomeric DNA to the inner nuclear membrane and
CC       replacement of the protective cap of telomeric chromosomes: in early
CC       meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA
CC       and the shelterin/telosome complex. During prophase, the complex
CC       matures and promotes release of the shelterin/telosome complex from
CC       telomeric DNA. {ECO:0000250|UniProtKB:Q9D494}.
CC   -!- SUBUNIT: Component of the MAJIN-TERB1-TERB2 complex, composed of MAJIN,
CC       TERB1 and TERB2. {ECO:0000250|UniProtKB:Q9D494}.
CC   -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC       {ECO:0000250|UniProtKB:Q9D494}. Nucleus inner membrane
CC       {ECO:0000250|UniProtKB:Q9D494}. Note=Localizes to telomeres throughout
CC       meiotic prophase I and disappears in metaphase I. In leptotene
CC       spermatocytes, localizes to telomeres that localize to the nucleus
CC       inner membrane. {ECO:0000250|UniProtKB:Q9D494}.
CC   -!- SIMILARITY: Belongs to the TERB2 family. {ECO:0000305}.
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DR   EMBL; BC111624; AAI11625.1; -; mRNA.
DR   RefSeq; NP_001070546.1; NM_001077078.2.
DR   AlphaFoldDB; Q2M2T9; -.
DR   SMR; Q2M2T9; -.
DR   STRING; 9913.ENSBTAP00000007813; -.
DR   PRIDE; Q2M2T9; -.
DR   Ensembl; ENSBTAT00000007813; ENSBTAP00000007813; ENSBTAG00000005954.
DR   GeneID; 768019; -.
DR   KEGG; bta:768019; -.
DR   CTD; 145645; -.
DR   VEuPathDB; HostDB:ENSBTAG00000005954; -.
DR   VGNC; VGNC:55147; TERB2.
DR   eggNOG; ENOG502S1BT; Eukaryota.
DR   GeneTree; ENSGT00390000012336; -.
DR   OMA; SPEKHFI; -.
DR   OrthoDB; 1206947at2759; -.
DR   Proteomes; UP000009136; Chromosome 10.
DR   Bgee; ENSBTAG00000005954; Expressed in semen and 11 other tissues.
DR   GO; GO:0000781; C:chromosome, telomeric region; ISS:UniProtKB.
DR   GO; GO:0005637; C:nuclear inner membrane; ISS:UniProtKB.
DR   GO; GO:0007129; P:homologous chromosome pairing at meiosis; ISS:UniProtKB.
DR   GO; GO:0070197; P:meiotic attachment of telomere to nuclear envelope; ISS:UniProtKB.
DR   GO; GO:0045141; P:meiotic telomere clustering; ISS:UniProtKB.
DR   InterPro; IPR028065; TERB2.
DR   PANTHER; PTHR35345; PTHR35345; 1.
DR   Pfam; PF15101; TERB2; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; Membrane; Nucleus; Reference proteome; Telomere.
FT   CHAIN           1..221
FT                   /note="Telomere repeats-binding bouquet formation protein
FT                   2"
FT                   /id="PRO_0000263716"
SQ   SEQUENCE   221 AA;  25381 MW;  DD718DF83789A576 CRC64;
     MFQGQRGWFC GSVSHDLRQF WVAEGGTISD PRAADFLFSC DASHPDTLRI YQSLDYIEDN
     ATVFHAYYLS AVANAEIKNS VALGHFILPP ASLQKEIRRK IGSFIWEQDQ HFLIEKHDEV
     TSNELKVFRE SSVLATDHKK DLSKSTEKHF IRTPVVEKQM YFPLQHYPVN NMVTGYISID
     AMKKFLGELH DFIPGSSGYL AYHVQNEINM SAIKNKLKNK Y
 
 
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