TERB2_BOVIN
ID TERB2_BOVIN Reviewed; 221 AA.
AC Q2M2T9;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-FEB-2006, sequence version 1.
DT 03-AUG-2022, entry version 60.
DE RecName: Full=Telomere repeats-binding bouquet formation protein 2 {ECO:0000250|UniProtKB:Q9D494};
GN Name=TERB2 {ECO:0000250|UniProtKB:Q9D494};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Testis;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Meiosis-specific telomere-associated protein involved in
CC meiotic telomere attachment to the nucleus inner membrane, a crucial
CC step for homologous pairing and synapsis. Component of the MAJIN-TERB1-
CC TERB2 complex, which promotes telomere cap exchange by mediating
CC attachment of telomeric DNA to the inner nuclear membrane and
CC replacement of the protective cap of telomeric chromosomes: in early
CC meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA
CC and the shelterin/telosome complex. During prophase, the complex
CC matures and promotes release of the shelterin/telosome complex from
CC telomeric DNA. {ECO:0000250|UniProtKB:Q9D494}.
CC -!- SUBUNIT: Component of the MAJIN-TERB1-TERB2 complex, composed of MAJIN,
CC TERB1 and TERB2. {ECO:0000250|UniProtKB:Q9D494}.
CC -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC {ECO:0000250|UniProtKB:Q9D494}. Nucleus inner membrane
CC {ECO:0000250|UniProtKB:Q9D494}. Note=Localizes to telomeres throughout
CC meiotic prophase I and disappears in metaphase I. In leptotene
CC spermatocytes, localizes to telomeres that localize to the nucleus
CC inner membrane. {ECO:0000250|UniProtKB:Q9D494}.
CC -!- SIMILARITY: Belongs to the TERB2 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC111624; AAI11625.1; -; mRNA.
DR RefSeq; NP_001070546.1; NM_001077078.2.
DR AlphaFoldDB; Q2M2T9; -.
DR SMR; Q2M2T9; -.
DR STRING; 9913.ENSBTAP00000007813; -.
DR PRIDE; Q2M2T9; -.
DR Ensembl; ENSBTAT00000007813; ENSBTAP00000007813; ENSBTAG00000005954.
DR GeneID; 768019; -.
DR KEGG; bta:768019; -.
DR CTD; 145645; -.
DR VEuPathDB; HostDB:ENSBTAG00000005954; -.
DR VGNC; VGNC:55147; TERB2.
DR eggNOG; ENOG502S1BT; Eukaryota.
DR GeneTree; ENSGT00390000012336; -.
DR OMA; SPEKHFI; -.
DR OrthoDB; 1206947at2759; -.
DR Proteomes; UP000009136; Chromosome 10.
DR Bgee; ENSBTAG00000005954; Expressed in semen and 11 other tissues.
DR GO; GO:0000781; C:chromosome, telomeric region; ISS:UniProtKB.
DR GO; GO:0005637; C:nuclear inner membrane; ISS:UniProtKB.
DR GO; GO:0007129; P:homologous chromosome pairing at meiosis; ISS:UniProtKB.
DR GO; GO:0070197; P:meiotic attachment of telomere to nuclear envelope; ISS:UniProtKB.
DR GO; GO:0045141; P:meiotic telomere clustering; ISS:UniProtKB.
DR InterPro; IPR028065; TERB2.
DR PANTHER; PTHR35345; PTHR35345; 1.
DR Pfam; PF15101; TERB2; 1.
PE 2: Evidence at transcript level;
KW Chromosome; Membrane; Nucleus; Reference proteome; Telomere.
FT CHAIN 1..221
FT /note="Telomere repeats-binding bouquet formation protein
FT 2"
FT /id="PRO_0000263716"
SQ SEQUENCE 221 AA; 25381 MW; DD718DF83789A576 CRC64;
MFQGQRGWFC GSVSHDLRQF WVAEGGTISD PRAADFLFSC DASHPDTLRI YQSLDYIEDN
ATVFHAYYLS AVANAEIKNS VALGHFILPP ASLQKEIRRK IGSFIWEQDQ HFLIEKHDEV
TSNELKVFRE SSVLATDHKK DLSKSTEKHF IRTPVVEKQM YFPLQHYPVN NMVTGYISID
AMKKFLGELH DFIPGSSGYL AYHVQNEINM SAIKNKLKNK Y