TERB2_MOUSE
ID TERB2_MOUSE Reviewed; 218 AA.
AC Q9D494;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Telomere repeats-binding bouquet formation protein 2 {ECO:0000303|PubMed:26548954};
GN Name=Terb2 {ECO:0000303|PubMed:26548954};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, IDENTIFICATION BY MASS
RP SPECTROMETRY, IDENTIFICATION IN THE MAJIN-TERB1-TERB2 COMPLEX, AND
RP DISRUPTION PHENOTYPE.
RX PubMed=26548954; DOI=10.1016/j.cell.2015.10.030;
RA Shibuya H., Hernandez-Hernandez A., Morimoto A., Negishi L., Hoeoeg C.,
RA Watanabe Y.;
RT "MAJIN links telomeric DNA to the nuclear membrane by exchanging telomere
RT cap.";
RL Cell 163:1252-1266(2015).
CC -!- FUNCTION: Meiosis-specific telomere-associated protein involved in
CC meiotic telomere attachment to the nucleus inner membrane, a crucial
CC step for homologous pairing and synapsis. Component of the MAJIN-TERB1-
CC TERB2 complex, which promotes telomere cap exchange by mediating
CC attachment of telomeric DNA to the inner nuclear membrane and
CC replacement of the protective cap of telomeric chromosomes: in early
CC meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA
CC and the shelterin/telosome complex. During prophase, the complex
CC matures and promotes release of the shelterin/telosome complex from
CC telomeric DNA. {ECO:0000269|PubMed:26548954}.
CC -!- SUBUNIT: Component of the MAJIN-TERB1-TERB2 complex, composed of MAJIN,
CC TERB1 and TERB2. {ECO:0000269|PubMed:26548954}.
CC -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC {ECO:0000269|PubMed:26548954}. Nucleus inner membrane
CC {ECO:0000269|PubMed:26548954}. Note=Localizes to telomeres throughout
CC meiotic prophase I and disappears in metaphase I. In leptotene
CC spermatocytes, localizes to telomeres that localize to the nucleus
CC inner membrane. {ECO:0000269|PubMed:26548954}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in germline tissues.
CC {ECO:0000269|PubMed:26548954}.
CC -!- DISRUPTION PHENOTYPE: Mice develop normally, exhibit no overt
CC phenotype, but are infertile (both males and females). Gonads are
CC characterized by the absence of post-meiotic cells.
CC {ECO:0000269|PubMed:26548954}.
CC -!- SIMILARITY: Belongs to the TERB2 family. {ECO:0000305}.
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DR EMBL; AK016695; BAB30384.1; -; mRNA.
DR CCDS; CCDS50688.1; -.
DR RefSeq; NP_083190.1; NM_028914.1.
DR AlphaFoldDB; Q9D494; -.
DR SMR; Q9D494; -.
DR STRING; 10090.ENSMUSP00000028661; -.
DR iPTMnet; Q9D494; -.
DR PhosphoSitePlus; Q9D494; -.
DR PaxDb; Q9D494; -.
DR PRIDE; Q9D494; -.
DR ProteomicsDB; 263106; -.
DR Antibodypedia; 52480; 6 antibodies from 3 providers.
DR Ensembl; ENSMUST00000028661; ENSMUSP00000028661; ENSMUSG00000027229.
DR GeneID; 74401; -.
DR KEGG; mmu:74401; -.
DR UCSC; uc008mai.2; mouse.
DR CTD; 145645; -.
DR MGI; MGI:1921651; Terb2.
DR VEuPathDB; HostDB:ENSMUSG00000027229; -.
DR eggNOG; ENOG502S1BT; Eukaryota.
DR GeneTree; ENSGT00390000012336; -.
DR HOGENOM; CLU_109637_0_0_1; -.
DR InParanoid; Q9D494; -.
DR OMA; SPEKHFI; -.
DR OrthoDB; 1206947at2759; -.
DR PhylomeDB; Q9D494; -.
DR TreeFam; TF336969; -.
DR BioGRID-ORCS; 74401; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Terb2; mouse.
DR PRO; PR:Q9D494; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9D494; protein.
DR Bgee; ENSMUSG00000027229; Expressed in spermatocyte and 21 other tissues.
DR ExpressionAtlas; Q9D494; baseline and differential.
DR Genevisible; Q9D494; MM.
DR GO; GO:0000781; C:chromosome, telomeric region; IDA:UniProtKB.
DR GO; GO:0005637; C:nuclear inner membrane; IDA:UniProtKB.
DR GO; GO:0007129; P:homologous chromosome pairing at meiosis; IMP:UniProtKB.
DR GO; GO:0070197; P:meiotic attachment of telomere to nuclear envelope; IMP:UniProtKB.
DR GO; GO:0045141; P:meiotic telomere clustering; IMP:UniProtKB.
DR InterPro; IPR028065; TERB2.
DR PANTHER; PTHR35345; PTHR35345; 1.
DR Pfam; PF15101; TERB2; 1.
PE 1: Evidence at protein level;
KW Chromosome; Meiosis; Membrane; Nucleus; Reference proteome; Telomere.
FT CHAIN 1..218
FT /note="Telomere repeats-binding bouquet formation protein
FT 2"
FT /id="PRO_0000263718"
FT REGION 117..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 218 AA; 25030 MW; 25DEF77BA986E0FB CRC64;
MFQGQRGWFC GSVSQDLRQI WEDEGGMVSD VKAADFLFSC DASHPDTLRI YQSLEYIEDN
ATVFHAYYLA AIANTEMKNS VALGHFVLPP ACLQKEIRRK IGSFIWEQDE KFQIEKHDRM
ASSDKENIRP TPEHKQELSK SAEHHLTRTP VIEKQMCFPL HSYPVNNMVT GYISIDALEK
FLGELHDFTP GSSGYLAYHI QDEINMSAIK NKLRRKLS
