ID   TERC_ALCSP              Reviewed;         346 AA.
AC   P18780;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Tellurium resistance protein TerC;
GN   Name=terC;
OS   Alcaligenes sp.
OG   Plasmid IncHI2 pMER610.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Alcaligenes.
OX   NCBI_TaxID=512;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3049247; DOI=10.1016/0378-1119(88)90361-7;
RA   Jobling M.G., Ritchie D.A.;
RT   "The nucleotide sequence of a plasmid determinant for resistance to
RT   tellurium anions.";
RL   Gene 66:245-258(1988).
CC   -!- FUNCTION: Could conceivably alter the intracellular level of tellurium
CC       in a manner leading to resistance. Alternatively its presence in the
CC       membrane may provide a barrier to entry of the tellurium ions.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the TerC family. {ECO:0000305}.
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DR   EMBL; M20238; AAA98291.1; -; Genomic_DNA.
DR   PIR; JT0363; C30754.
DR   AlphaFoldDB; P18780; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046690; P:response to tellurium ion; IEA:UniProtKB-KW.
DR   InterPro; IPR005496; Integral_membrane_TerC.
DR   InterPro; IPR022369; Integral_membrane_TerC_rswitch.
DR   PANTHER; PTHR30238:SF0; PTHR30238:SF0; 1.
DR   Pfam; PF03741; TerC; 1.
DR   TIGRFAMs; TIGR03718; R_switched_Alx; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Plasmid; Tellurium resistance; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..346
FT                   /note="Tellurium resistance protein TerC"
FT                   /id="PRO_0000103408"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        227..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        252..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        286..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   346 AA;  38230 MW;  8C69AFAE2A07F71E CRC64;
     MVSTHIGGPA ETVTVFVALS VGAIFIDLFM HRHDKPISLK SAALWSVFWV VVAMAFAGFL
     YVHHGAEVAS LFVTGYALEK VLSVDNLFVM MAIFSWFSVP DRYRHRGLYW GIIGAIVFRG
     IFVAIGTGLL SLGPYVELIF AVVVAWTAVM MLKGGGDDDE IEDYSQHLAY RLVKRFFPIW
     PKLSGHAFLL TQKEVDAELA KPENKDVSVG RLKKAALYAT PLMLCVAVVE LSDVMFAFDS
     VPAIIAVSRE PLIVYSAMMF AILGLRTLYF VLEALKQYLS QLEKAVIVLL FFIAFKLGLN
     ATDHIWHHGY SLSATTSLYV VLGVLALGIL ASVIFPEKPE AENKES