TERG_ASPTN
ID TERG_ASPTN Reviewed; 531 AA.
AC Q0D1P6;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 1.
DT 25-MAY-2022, entry version 68.
DE RecName: Full=Efflux pump terG {ECO:0000305|PubMed:24816227};
DE AltName: Full=Terrein biosynthesis cluster protein terG {ECO:0000303|PubMed:24816227};
GN Name=terG {ECO:0000303|PubMed:24816227}; ORFNames=ATEG_00138;
OS Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=341663;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIH 2624 / FGSC A1156;
RA Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA Nierman W.C., Milne T., Madden K.;
RT "Annotation of the Aspergillus terreus NIH2624 genome.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP FUNCTION.
RX PubMed=24816227; DOI=10.1016/j.chembiol.2014.03.010;
RA Zaehle C., Gressler M., Shelest E., Geib E., Hertweck C., Brock M.;
RT "Terrein biosynthesis in Aspergillus terreus and its impact on
RT phytotoxicity.";
RL Chem. Biol. 21:719-731(2014).
RN [3]
RP INDUCTION.
RX PubMed=25852654; DOI=10.3389/fmicb.2015.00184;
RA Gressler M., Hortschansky P., Geib E., Brock M.;
RT "A new high-performance heterologous fungal expression system based on
RT regulatory elements from the Aspergillus terreus terrein gene cluster.";
RL Front. Microbiol. 6:184-184(2015).
CC -!- FUNCTION: Efflux pump that might be required for efficient secretion of
CC terrein or other secondary metabolies produced by the terrein genne
CC cluster (PubMed:24816227). {ECO:0000269|PubMed:24816227}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- INDUCTION: Expression is under the control of the terrein cluster-
CC specific transcription factor terR (PubMed:25852654).
CC {ECO:0000269|PubMed:25852654}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; CH476594; EAU38784.1; -; Genomic_DNA.
DR RefSeq; XP_001210224.1; XM_001210224.1.
DR AlphaFoldDB; Q0D1P6; -.
DR SMR; Q0D1P6; -.
DR EnsemblFungi; EAU38784; EAU38784; ATEG_00138.
DR GeneID; 4354895; -.
DR VEuPathDB; FungiDB:ATEG_00138; -.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_000960_27_4_1; -.
DR OMA; SSMFTNQ; -.
DR OrthoDB; 595536at2759; -.
DR Proteomes; UP000007963; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..531
FT /note="Efflux pump terG"
FT /id="PRO_0000437599"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 280..300
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 319..339
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 351..371
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 380..400
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 402..422
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 447..467
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 488..508
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 531 AA; 57837 MW; D8CBE6AD7A4B6F41 CRC64;
MSSSTLEGQE TASHHSKNSP SRHGDDGGLQ TAGDEYVYIA DHYGMVRRMI FIMTVCSSMF
TNQLGLCNSL STLEEIGESF GVTDPGKLSW TISGYGLTLG TFILIGGRLG DEFGNKAIFV
IGMGWLALTS MMAGVSVYAG YPVYILARVL QGLGPALTVP NALAIMGKCF SEHPRNMGFA
WFAASAPVGA MAGLLFGPLF TMAWWPWIYW SQALGVAFVF ALSIVAIPNM PAESEQKQRR
TILEILERID LLGGACGVTA LVLFNFAWNQ SLVATWKEPY VYVCLILSFL FLAAFFYVEL
RVARHPILPV AVLTSDIAFV FGCTAAGWST FGIWLFYVIR ICLNIGGQTP IQMAAWLSPI
LVTGIGTALI VGKIITKVPA SSIMLFAMLC YFITSLLMAL RPVHSIYWTY FFFATIIATF
AMDSSLPAAT IIFANAVPRQ YQGMGSSVIM TIVVYSISLG LGFAGTIELQ INNGGHTKAD
LLHGYRGTLW FSVGLTAFGT VLALIFLLKD LRRRKLARTQ VEEEKGHSSE A
