TERJ_ASPTN
ID TERJ_ASPTN Reviewed; 518 AA.
AC Q0D1P9;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 1.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=Efflux pump terJ {ECO:0000305|PubMed:24816227};
DE AltName: Full=Terrein biosynthesis cluster protein terJ {ECO:0000303|PubMed:24816227};
GN Name=terJ {ECO:0000303|PubMed:24816227}; ORFNames=ATEG_00135;
OS Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=341663;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIH 2624 / FGSC A1156;
RA Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA Nierman W.C., Milne T., Madden K.;
RT "Annotation of the Aspergillus terreus NIH2624 genome.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP FUNCTION.
RX PubMed=24816227; DOI=10.1016/j.chembiol.2014.03.010;
RA Zaehle C., Gressler M., Shelest E., Geib E., Hertweck C., Brock M.;
RT "Terrein biosynthesis in Aspergillus terreus and its impact on
RT phytotoxicity.";
RL Chem. Biol. 21:719-731(2014).
RN [3]
RP INDUCTION.
RX PubMed=25852654; DOI=10.3389/fmicb.2015.00184;
RA Gressler M., Hortschansky P., Geib E., Brock M.;
RT "A new high-performance heterologous fungal expression system based on
RT regulatory elements from the Aspergillus terreus terrein gene cluster.";
RL Front. Microbiol. 6:184-184(2015).
CC -!- FUNCTION: Efflux pump that might be required for efficient secretion of
CC terrein or other secondary metabolies produced by the terrein genne
CC cluster (PubMed:24816227). {ECO:0000269|PubMed:24816227}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- INDUCTION: Expression is under the control of the terrein cluster-
CC specific transcription factor terR (PubMed:25852654).
CC {ECO:0000269|PubMed:25852654}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH476594; EAU38781.1; -; Genomic_DNA.
DR RefSeq; XP_001210221.1; XM_001210221.1.
DR AlphaFoldDB; Q0D1P9; -.
DR SMR; Q0D1P9; -.
DR STRING; 341663.Q0D1P9; -.
DR EnsemblFungi; EAU38781; EAU38781; ATEG_00135.
DR GeneID; 4354892; -.
DR VEuPathDB; FungiDB:ATEG_00135; -.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_000960_27_4_1; -.
DR OrthoDB; 595536at2759; -.
DR Proteomes; UP000007963; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008519; F:ammonium transmembrane transporter activity; IEA:EnsemblFungi.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..518
FT /note="Efflux pump terJ"
FT /id="PRO_0000437601"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 311..331
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 364..384
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 400..420
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 439..459
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 477..497
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 79
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 466
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 518 AA; 56129 MW; 997658005A42509D CRC64;
MSRNDVIDDE VHGVHGEYDD SSTLTGSHED LDVKRPQSLS GEIAFIVVVC MAQLVSQAGL
GQVISILPVL GDSFGIGNNM SQLSWFPAAY SLTVGTFILG AGRLGDLYGH KLLFTAGYFW
LAIWTLVAAF AESSGPVFFC CCRVLQGIGP AFLLPNGMAI LARSYEPGTR KEMVFSAFGS
TAPSGFIFGG LVSALAAKYQ SWPWGFWFMA ILEAVCGIAA IFWVPRTPTP RRETTHSLWA
RMDIAGCVTG ISGLLLFNVA LNMAPGARWQ DPYIYILLIA SLVFFGLFGY IERKAVFPLI
PFSAITPDIS FVLATLACGW AAFGVWVFYG WEFVQNFRGI SPLFACLQFS PAAISGFVAS
FTTGLILQKL PASVVMMISA AAFCTADTLY ATMPIAQSYW AQLFVSIIVM PWGMEMSFPA
SNILLSNAMP QEHQGVSASL VATIMNYAIS LGLGFGAIVE TDLNKNGTDL LRGYRGAWYL
GVGLAASGII LTMFFALHEY RKSVPMKNKA ASREEYLA
