ID   TERL_ASPTN              Reviewed;         141 AA.
AC   Q0CRX8;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2012, sequence version 2.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Terrelysin;
DE   AltName: Full=Hemolysin;
GN   ORFNames=ATEG_03556;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA   Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   REVISION OF GENE MODEL, AND FUNCTION.
RC   STRAIN=ATCC 1012 / CBS 601.65 / NRRL 255;
RX   PubMed=20632211; DOI=10.1007/s11046-010-9343-0;
RA   Nayak A.P., Blachere F.M., Hettick J.M., Lukomski S., Schmechel D.,
RA   Beezhold D.H.;
RT   "Characterization of recombinant terrelysin, a hemolysin of Aspergillus
RT   terreus.";
RL   Mycopathologia 171:23-34(2011).
RN   [3]
RP   DEVELOPMENTAL STAGE, AND SUBCELLULAR LOCATION.
RX   PubMed=22160315; DOI=10.1099/jmm.0.039511-0;
RA   Nayak A.P., Green B.J., Friend S., Beezhold D.H.;
RT   "Development of monoclonal antibodies to recombinant terrelysin and
RT   characterization of expression in Aspergillus terreus.";
RL   J. Med. Microbiol. 61:489-499(2012).
CC   -!- FUNCTION: Hemolysins are potential virulence factors. Has hemolytic
CC       activity against sheep erythrocytes in vitro.
CC       {ECO:0000269|PubMed:20632211}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22160315}.
CC       Note=Appears to be more abundant at the hyphal tip.
CC   -!- DEVELOPMENTAL STAGE: Expression is highest during early hyphal growth
CC       and dramatically reduced after mycelial expansion.
CC       {ECO:0000269|PubMed:22160315}.
CC   -!- SIMILARITY: Belongs to the aegerolysin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAU36830.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH476597; EAU36830.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001212734.1; XM_001212734.1.
DR   AlphaFoldDB; Q0CRX8; -.
DR   SMR; Q0CRX8; -.
DR   TCDB; 1.C.119.1.3; the aegerolysin (aegerolysin) family.
DR   PRIDE; Q0CRX8; -.
DR   GeneID; 4317936; -.
DR   OrthoDB; 1564258at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019836; P:hemolysis by symbiont of host erythrocytes; IEA:InterPro.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR009413; Aegerolysin-typ.
DR   Pfam; PF06355; Aegerolysin; 1.
PE   2: Evidence at transcript level;
KW   Cytolysis; Cytoplasm; Hemolysis; Reference proteome.
FT   CHAIN           1..141
FT                   /note="Terrelysin"
FT                   /id="PRO_0000416023"
SQ   SEQUENCE   141 AA;  15806 MW;  3B8AC4DEE87EB41D CRC64;
     MDDSQWVSIH IRDRLAQGNI TIRESFLYEG QFHSPEDEKK ALTEDDIDQL IIPSEGIGEV
     CARGRRGSEG WMDLFDGEKK ICELHWDNRT KRPSNEFEVI DGDKDYKIEC SGWSPQAGPL
     GHVFIDISAA KKKAAAAAAA K