ID   TERM_BPCP1              Reviewed;         230 AA.
AC   Q37988;
DT   31-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   29-SEP-2021, entry version 63.
DE   RecName: Full=Terminal protein;
GN   Name=4;
OS   Streptococcus phage Cp-1 (Bacteriophage Cp-1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Salasmaviridae; Cepunavirus.
OX   NCBI_TaxID=10747;
OH   NCBI_TaxID=1313; Streptococcus pneumoniae.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7645213; DOI=10.1006/viro.1995.1375;
RA   Martin A.C., Lopez R., Garcia P.;
RT   "Nucleotide sequence and transcription of the left early region of
RT   Streptococcus pneumoniae bacteriophage Cp-1 coding for the terminal protein
RT   and the DNA polymerase.";
RL   Virology 211:21-32(1995).
RN   [2]
RP   FUNCTION, AND COVALENT DNA LINKAGE.
RX   PubMed=3081736; DOI=10.1128/jvi.58.1.31-35.1986;
RA   Garcia P., Hermoso J.M., Garcia J.A., Garcia E., Lopez R., Salas M.;
RT   "Formation of a covalent complex between the terminal protein of
RT   pneumococcal bacteriophage Cp-1 and 5'-dAMP.";
RL   J. Virol. 58:31-35(1986).
RN   [3]
RP   FUNCTION.
RX   PubMed=8757800; DOI=10.1006/jmbi.1996.0407;
RA   Martin A.C., Blanco L., Garcia P., Salas M., Mendez J.;
RT   "In vitro protein-primed initiation of pneumococcal phage Cp-1 DNA
RT   replication occurs at the third 3' nucleotide of the linear template: a
RT   stepwise sliding-back mechanism.";
RL   J. Mol. Biol. 260:369-377(1996).
RN   [4]
RP   SUBCELLULAR LOCATION, AND NUCLEAR LOCALIZATION SIGNAL.
RX   PubMed=23091024; DOI=10.1073/pnas.1216635109;
RA   Redrejo-Rodriguez M., Munoz-Espin D., Holguera I., Mencia M., Salas M.;
RT   "Functional eukaryotic nuclear localization signals are widespread in
RT   terminal proteins of bacteriophages.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:18482-18487(2012).
CC   -!- FUNCTION: DNA terminal protein is linked to the 5'-ends of both strands
CC       of the genome through a phosphodiester bond between the beta-hydroxyl
CC       group of a threonine residue and the 5'-phosphate of the terminal
CC       deoxyadenylate (PubMed:3081736). This protein is essential for DNA
CC       replication and is involved in the priming of DNA elongation
CC       (PubMed:8757800). {ECO:0000269|PubMed:3081736,
CC       ECO:0000269|PubMed:8757800}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000269|PubMed:23091024}.
CC       Virion {ECO:0000305}.
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DR   EMBL; Z47794; CAA87724.1; -; Genomic_DNA.
DR   PIR; S51274; S51274.
DR   RefSeq; NP_044816.1; NC_001825.1.
DR   SMR; Q37988; -.
DR   GeneID; 1261228; -.
DR   KEGG; vg:1261228; -.
DR   Proteomes; UP000009089; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
PE   4: Predicted;
KW   Covalent protein-DNA linkage; DNA replication; Host nucleus;
KW   Reference proteome; Virion.
FT   CHAIN           1..230
FT                   /note="Terminal protein"
FT                   /id="PRO_0000106553"
FT   MOTIF           222..230
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000269|PubMed:23091024"
SQ   SEQUENCE   230 AA;  26898 MW;  09081DB498F44461 CRC64;
     MALTPKQRKV RRDYLTRKKR TLQQQGASNA EIKAFMGGRW NFAGMSDKAL ERAYDEIKSK
     GRTQVFGNHV YTSDYVKKAK AWYGDKFSVE KLTQGFRSSQ RSELNRFHSV KEVKEYRSER
     DREAKERYIQ ALEEMHYNTR DAGNKAQEKA FKSMISRIRR MSASNFGAFL TGGRSDKVSF
     DNVMVFVDTD GKETAFEFQD SLAREILDNV DKFSKQFVSD MRRRKKRGKK