ID   TES26_TOXCA             Reviewed;         262 AA.
AC   P54190;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=26 kDa secreted antigen;
DE   AltName: Full=Toxocara excretory-secretory antigen 26;
DE            Short=TES-26;
DE   Flags: Precursor;
GN   Name=TES-26;
OS   Toxocara canis (Canine roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX   NCBI_TaxID=6265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7629180; DOI=10.1074/jbc.270.31.18517;
RA   Gems D., Ferguson C.J., Robertson B.D., Nieves R., Page A.P., Blaxter M.L.,
RA   Maizels R.M.;
RT   "An abundant, trans-spliced mRNA from Toxocara canis infective larvae
RT   encodes a 26-kDa protein with homology to phosphatidylethanolamine-binding
RT   proteins.";
RL   J. Biol. Chem. 270:18517-18522(1995).
CC   -!- FUNCTION: Binds phosphatidylethanolamine.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- DEVELOPMENTAL STAGE: Found in larva, but not in the adult parasite.
CC   -!- SIMILARITY: Belongs to the phosphatidylethanolamine-binding protein
CC       family. {ECO:0000305}.
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DR   EMBL; U29761; AAC46843.1; -; mRNA.
DR   PIR; A57391; A57391.
DR   AlphaFoldDB; P54190; -.
DR   SMR; P54190; -.
DR   Proteomes; UP000050794; Genome assembly.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   CDD; cd00866; PEBP_euk; 1.
DR   Gene3D; 3.90.280.10; -; 1.
DR   InterPro; IPR008914; PEBP.
DR   InterPro; IPR036610; PEBP-like_sf.
DR   InterPro; IPR035810; PEBP_euk.
DR   InterPro; IPR001858; Phosphatidylethanolamine-bd_CS.
DR   InterPro; IPR003582; ShKT_dom.
DR   PANTHER; PTHR11362; PTHR11362; 1.
DR   Pfam; PF01161; PBP; 1.
DR   Pfam; PF01549; ShK; 2.
DR   SMART; SM00254; ShKT; 2.
DR   SUPFAM; SSF49777; SSF49777; 1.
DR   PROSITE; PS01220; PBP; 1.
DR   PROSITE; PS51670; SHKT; 2.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Lipid-binding; Repeat; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..262
FT                   /note="26 kDa secreted antigen"
FT                   /id="PRO_0000023283"
FT   DOMAIN          23..57
FT                   /note="ShKT 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01005"
FT   DOMAIN          59..93
FT                   /note="ShKT 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01005"
FT   DISULFID        23..57
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01005"
FT   DISULFID        30..50
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01005"
FT   DISULFID        37..54
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01005"
FT   DISULFID        59..93
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01005"
FT   DISULFID        66..86
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01005"
FT   DISULFID        73..90
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01005"
SQ   SEQUENCE   262 AA;  28049 MW;  426ED0DE5CC070A1 CRC64;
     MSVVHKACLI ALLFVSSGVA QQCMDSASDC AANAGSCFTR PVSQVLQNRC QRTCNTCDCR
     DEANNCAASI NLCQNPTFEP LVRDRCQKTC GLCAGCGFIS SGIVPLVVTS APSRRVSVTF
     ANNVQVNCGN TLTTAQVANQ PTVTWEAQPN DRYTLIMVDP DFPSAANGQQ GQRLHWWVIN
     IPGNNIAGGT TLAAFQPSTP AANTGVHRYV FLVYRQPAAI NSPLLNNLVV QDSERPGFGT
     TAFATQFNLG SPYAGNFYRS QA