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BRCA1_ARATH
ID   BRCA1_ARATH             Reviewed;         941 AA.
AC   Q8RXD4; Q9SUA7;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 144.
DE   RecName: Full=Protein BREAST CANCER SUSCEPTIBILITY 1 homolog {ECO:0000303|PubMed:12582233};
DE            Short=AtBRCA1 {ECO:0000303|PubMed:12582233};
GN   Name=BRCA1 {ECO:0000303|PubMed:12582233};
GN   OrderedLocusNames=At4g21070 {ECO:0000312|Araport:AT4G21070};
GN   ORFNames=T13K14.230 {ECO:0000312|EMBL:CAB45902.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], INDUCTION BY GAMMA RAYS, AND TISSUE
RP   SPECIFICITY.
RC   STRAIN=cv. Columbia;
RX   PubMed=12582233; DOI=10.1093/nar/gkg202;
RA   Lafarge S., Montane M.-H.;
RT   "Characterization of Arabidopsis thaliana ortholog of the human breast
RT   cancer susceptibility gene 1: AtBRCA1, strongly induced by gamma rays.";
RL   Nucleic Acids Res. 31:1148-1155(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617198; DOI=10.1038/47134;
RA   Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA   Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA   Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA   de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA   Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA   Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA   Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA   Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA   Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA   Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA   Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA   Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA   Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA   Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA   Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA   Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA   Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA   Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA   Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA   Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA   Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA   Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA   Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA   Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA   Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA   Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA   de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA   Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA   Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA   Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA   Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA   Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA   Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA   Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA   Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA   Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA   O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA   Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA   Martienssen R., McCombie W.R.;
RT   "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL   Nature 402:769-777(1999).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [5]
RP   FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH BARD1/ROW1, INDUCTION BY
RP   GAMMA RAYS, TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX   PubMed=16957774; DOI=10.1038/sj.emboj.7601313;
RA   Reidt W., Wurz R., Wanieck K., Chu H.H., Puchta H.;
RT   "A homologue of the breast cancer-associated gene BARD1 is involved in DNA
RT   repair in plants.";
RL   EMBO J. 25:4326-4337(2006).
RN   [6]
RP   REVIEW, AND GENE FAMILY.
RX   PubMed=22629260; DOI=10.3389/fpls.2011.00019;
RA   Trapp O., Seeliger K., Puchta H.;
RT   "Homologs of breast cancer genes in plants.";
RL   Front. Plant Sci. 2:19-19(2011).
CC   -!- FUNCTION: Plays a role in DNA repair and in cell-cycle control.
CC       Required for the repair of DNA double-strand breaks (DSBs), both
CC       natural and induced by genotoxic stress, by homologous recombination
CC       (HR). {ECO:0000269|PubMed:16957774}.
CC   -!- SUBUNIT: Forms heterodimer with BARD1/ROW1.
CC       {ECO:0000269|PubMed:16957774}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768,
CC       ECO:0000269|PubMed:16957774}.
CC   -!- TISSUE SPECIFICITY: Expressed ubiquitously with highest levels in
CC       flower buds (PubMed:12582233). Mostly expressed in flowers and
CC       siliques, and, to a lower extent, in roots, rosette leaves,
CC       inflorescence and young cauline leaves (PubMed:16957774).
CC       {ECO:0000269|PubMed:12582233, ECO:0000269|PubMed:16957774}.
CC   -!- INDUCTION: By gamma rays treatment. {ECO:0000269|PubMed:12582233,
CC       ECO:0000269|PubMed:16957774}.
CC   -!- DISRUPTION PHENOTYPE: Enhanced sensitivity to mitomycin C.
CC       {ECO:0000269|PubMed:16957774}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAB45902.1; Type=Erroneous gene model prediction; Note=The predicted gene has been split into 2 genes: At4g21065 and At4g21070.; Evidence={ECO:0000305};
CC       Sequence=CAB79107.1; Type=Erroneous gene model prediction; Note=The predicted gene has been split into 2 genes: At4g21065 and At4g21070.; Evidence={ECO:0000305};
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DR   EMBL; AY081328; AAL91217.1; -; mRNA.
DR   EMBL; AL080282; CAB45902.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AL161554; CAB79107.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002687; AEE84396.1; -; Genomic_DNA.
DR   EMBL; AF515728; AAO39850.1; -; mRNA.
DR   EMBL; BT010547; AAQ65170.1; -; mRNA.
DR   RefSeq; NP_193839.4; NM_118225.5.
DR   AlphaFoldDB; Q8RXD4; -.
DR   SMR; Q8RXD4; -.
DR   BioGRID; 13145; 1.
DR   STRING; 3702.AT4G21070.1; -.
DR   PaxDb; Q8RXD4; -.
DR   PRIDE; Q8RXD4; -.
DR   ProteomicsDB; 240501; -.
DR   EnsemblPlants; AT4G21070.1; AT4G21070.1; AT4G21070.
DR   GeneID; 827854; -.
DR   Gramene; AT4G21070.1; AT4G21070.1; AT4G21070.
DR   KEGG; ath:AT4G21070; -.
DR   Araport; AT4G21070; -.
DR   TAIR; locus:2133109; AT4G21070.
DR   eggNOG; KOG4362; Eukaryota.
DR   HOGENOM; CLU_004218_0_0_1; -.
DR   InParanoid; Q8RXD4; -.
DR   OMA; MKSGSNC; -.
DR   OrthoDB; 854133at2759; -.
DR   PhylomeDB; Q8RXD4; -.
DR   PRO; PR:Q8RXD4; -.
DR   Proteomes; UP000006548; Chromosome 4.
DR   ExpressionAtlas; Q8RXD4; baseline and differential.
DR   Genevisible; Q8RXD4; AT.
DR   GO; GO:0070531; C:BRCA1-A complex; IBA:GO_Central.
DR   GO; GO:0031436; C:BRCA1-BARD1 complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IDA:TAIR.
DR   GO; GO:0071480; P:cellular response to gamma radiation; IEP:UniProtKB.
DR   GO; GO:0006310; P:DNA recombination; IMP:TAIR.
DR   GO; GO:0006281; P:DNA repair; IMP:TAIR.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IMP:UniProtKB.
DR   GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IBA:GO_Central.
DR   GO; GO:0035067; P:negative regulation of histone acetylation; IBA:GO_Central.
DR   GO; GO:0035066; P:positive regulation of histone acetylation; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0010332; P:response to gamma radiation; IEP:TAIR.
DR   Gene3D; 3.30.40.10; -; 2.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR031099; BRCA1-associated.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR034732; EPHD.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   PANTHER; PTHR13763; PTHR13763; 1.
DR   Pfam; PF00533; BRCT; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   PIRSF; PIRSF001734; BRCA1; 1.
DR   SMART; SM00292; BRCT; 2.
DR   SMART; SM00184; RING; 1.
DR   SUPFAM; SSF52113; SSF52113; 2.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS51805; EPHD; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   1: Evidence at protein level;
KW   DNA damage; DNA repair; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..941
FT                   /note="Protein BREAST CANCER SUSCEPTIBILITY 1 homolog"
FT                   /id="PRO_0000363413"
FT   DOMAIN          724..819
FT                   /note="BRCT 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00033"
FT   DOMAIN          840..941
FT                   /note="BRCT 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00033"
FT   ZN_FING         16..54
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   ZN_FING         561..612
FT                   /note="C2HC pre-PHD-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01146"
FT   ZN_FING         632..681
FT                   /note="PHD-type; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01146"
FT   REGION          87..282
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          303..528
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           298..305
FT                   /note="Nuclear localization signal 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT   MOTIF           444..451
FT                   /note="Nuclear localization signal 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT   COMPBIAS        97..135
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        149..170
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        171..196
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        205..219
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        220..242
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        243..259
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        324..363
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        377..394
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        435..457
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        473..488
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        489..513
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        514..528
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   941 AA;  103922 MW;  4EF2D20BA443C9AA CRC64;
     MADTSHLERM GRELKCPICL SLYNSAVSLS CNHVFCNACI VKSMKMDATC PVCKIPYHRR
     EIRGAPHMDS LVSIYKNMED ASGIKLFVSQ NNPSPSDKEK QVRDASVEKA SDKNRQGSRK
     GRASKRNEYG KTKEIDVDAP GPIVMKPSSQ TKKRVQLLQN LSAESLTKPT ESVETAEKPK
     DYTENTVIRL DEHPSLNKEG NLSPFFWLRD EDDGENSSQR TESDQLLGTT PVNVPSFSDL
     MDSDHESPSK EDEQQKPNPG DMFDSEMFEW TQRPCSPEIL PSPVKAKVLG RDEIDLTQKK
     LPKVKVASSK CKNRKAGSAR NTVARRSIGV SQEDNMESSA AATISEQQDS RGTSGTIIRN
     DVNTDENVKA KRATRSKAQS TRVQSDLNVS NEADGKQGTK RKRSSIKSSP AHPIAGPNEL
     SLGTEIVGKG DQDQAHGPSD THPEKRSPTE KPSLKKRGRK SNASSSLKDL SGKTQKKTSE
     KKLKLDSHMI SSKATQPHGN GILTAGLNQG GDKQDSRNNR KSTVGKDDHT MQVIEKCSTI
     NKSSSGGSAH LRRCNGSLTK KFTCAFCQCS EDTEASGEMT HYYRGEPVSA DFNGGSKVIH
     VHKNCAEWAP NVYFNDLTIV NLDVELTRSR RISCSCCGLK GAALGCYNKS CKNSFHVTCA
     KLIPECRWDN VKFVMLCPLD ASIKLPCEEA NSKDRKCKRT PKEPLHSQPK QVSGKANIRE
     LHIKQFHGFS KKLVLSCSGL TVEEKTVIAE FAELSGVTIS KNWDSTVTHV IASINENGAC
     KRTLKFMMAI LEGKWILTID WIKACMKNTK YVSEEPYEIT MDVHGIREGP YLGRQRALKK
     KPKLFTGLKF YIMGDFELAY KGYLQDLIVA AGGTILRRRP VSSDDNEAST IVVFSVEPSK
     KKTLTQRRSD AEALAKSARA RAASSSWVLD SIAGCQILVL I
 
 
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