ID   TET12_ARATH             Reviewed;         264 AA.
AC   Q9FN51;
DT   06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Tetraspanin-12;
GN   Name=TET12; OrderedLocusNames=At5g23030; ORFNames=MYJ24.2;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9405937; DOI=10.1093/dnares/4.4.291;
RA   Kotani H., Nakamura Y., Sato S., Kaneko T., Asamizu E., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. II. Sequence
RT   features of the regions of 1,044,062 bp covered by thirteen physically
RT   assigned P1 clones.";
RL   DNA Res. 4:291-300(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Kim C.J., Chen H., Cheuk R.F., Shinn P., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in the regulation of cell differentiation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB006708; BAB09820.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED93110.1; -; Genomic_DNA.
DR   EMBL; BT010941; AAR24719.1; -; mRNA.
DR   EMBL; BT011655; AAS47661.1; -; mRNA.
DR   RefSeq; NP_197694.1; NM_122209.4.
DR   AlphaFoldDB; Q9FN51; -.
DR   BioGRID; 17642; 1.
DR   IntAct; Q9FN51; 1.
DR   STRING; 3702.AT5G23030.1; -.
DR   PaxDb; Q9FN51; -.
DR   PRIDE; Q9FN51; -.
DR   ProteomicsDB; 232814; -.
DR   EnsemblPlants; AT5G23030.1; AT5G23030.1; AT5G23030.
DR   GeneID; 832367; -.
DR   Gramene; AT5G23030.1; AT5G23030.1; AT5G23030.
DR   KEGG; ath:AT5G23030; -.
DR   Araport; AT5G23030; -.
DR   TAIR; locus:2178327; AT5G23030.
DR   eggNOG; ENOG502QTNI; Eukaryota.
DR   HOGENOM; CLU_066970_0_0_1; -.
DR   InParanoid; Q9FN51; -.
DR   OMA; FLYSCGC; -.
DR   OrthoDB; 1209030at2759; -.
DR   PhylomeDB; Q9FN51; -.
DR   PRO; PR:Q9FN51; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FN51; baseline and differential.
DR   Genevisible; Q9FN51; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009506; C:plasmodesma; IBA:GO_Central.
DR   GO; GO:0009734; P:auxin-activated signaling pathway; IEA:InterPro.
DR   InterPro; IPR044991; TET_plant.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   PANTHER; PTHR32191; PTHR32191; 1.
DR   Pfam; PF00335; Tetraspanin; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..264
FT                   /note="Tetraspanin-12"
FT                   /id="PRO_0000421052"
FT   TOPO_DOM        1..13
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        35..45
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        67..75
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        97..228
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        229..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        250..264
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        180
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   264 AA;  29499 MW;  4F84C97437A6B6DB CRC64;
     MLRLSNAAVI TTNAILALIG LAALSFSVYV YVQGPSQCQR FVQNPLIVTA ALLFFISSLG
     LIAALYGSHI IITLYLFFLF LSILLLLVLS VFIFLVTNPT AGKALSGRGI GNVKTGDYQN
     WIGNHFLRGK NWEGITKCLS DSRVCKRFGP RDIDFDSKHL SNVQFGCCRP PVECGFESKN
     ATWWTVPATA TTAIIGDCKA WSNTQRQLCY ACESCKIGVL KGIRKRWRIL IVVNLLLILL
     VVFLYSCGCC VRKNNRVPWK RRFF