TET19_ARATH
ID TET19_ARATH Reviewed; 221 AA.
AC Q940P5; F4IFI1; F4IFI2; Q9SKU3;
DT 06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Tetraspanin-19;
DE AltName: Full=TOM2A homologous protein 3;
GN Name=TOM2AH3; OrderedLocusNames=At2g20740; ORFNames=F5H14.29;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, DISRUPTION PHENOTYPE, AND TISSUE SPECIFICITY.
RX PubMed=18474569; DOI=10.1099/vir.0.2008/000539-0;
RA Fujisaki K., Kobayashi S., Tsujimoto Y., Naito S., Ishikawa M.;
RT "Analysis of tobamovirus multiplication in Arabidopsis thaliana mutants
RT defective in TOM2A homologues.";
RL J. Gen. Virol. 89:1519-1524(2008).
CC -!- FUNCTION: May be involved in the regulation of cell differentiation.
CC {ECO:0000269|PubMed:18474569}.
CC -!- FUNCTION: Promotes intracellular multiplication of tobamoviruses,
CC probably being a component of the replication complex.
CC {ECO:0000269|PubMed:18474569}.
CC -!- SUBUNIT: Homodimer. Constituent of tobamovirus replication complex (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000305}. Vacuole membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q940P5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q940P5-2; Sequence=VSP_045060;
CC Name=3;
CC IsoId=Q940P5-3; Sequence=VSP_045059;
CC -!- TISSUE SPECIFICITY: Expressed in rosette leaves.
CC {ECO:0000269|PubMed:18474569}.
CC -!- DISRUPTION PHENOTYPE: Slightly reduced efficiency of intracellular
CC multiplication of tobamoviruses (e.g. crucifer strain TMV-Cg),
CC characterized by a reduced amplification of TMV-related RNAs.
CC {ECO:0000269|PubMed:18474569}.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD20921.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC006234; AAD20921.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002685; AEC07063.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC07064.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC07065.1; -; Genomic_DNA.
DR EMBL; AF462842; AAL58930.1; -; mRNA.
DR EMBL; AY054217; AAL06877.1; -; mRNA.
DR EMBL; AY097350; AAM19866.1; -; mRNA.
DR EMBL; AK175553; BAD43316.1; -; mRNA.
DR EMBL; AK176086; BAD43849.1; -; mRNA.
DR PIR; G84592; G84592.
DR RefSeq; NP_179667.2; NM_127639.4. [Q940P5-1]
DR RefSeq; NP_973493.1; NM_201764.1. [Q940P5-2]
DR RefSeq; NP_973494.1; NM_201765.2. [Q940P5-3]
DR AlphaFoldDB; Q940P5; -.
DR SMR; Q940P5; -.
DR BioGRID; 1956; 1.
DR IntAct; Q940P5; 4.
DR STRING; 3702.AT2G20740.1; -.
DR iPTMnet; Q940P5; -.
DR PaxDb; Q940P5; -.
DR PRIDE; Q940P5; -.
DR ProteomicsDB; 232850; -. [Q940P5-1]
DR EnsemblPlants; AT2G20740.1; AT2G20740.1; AT2G20740. [Q940P5-1]
DR EnsemblPlants; AT2G20740.2; AT2G20740.2; AT2G20740. [Q940P5-2]
DR EnsemblPlants; AT2G20740.3; AT2G20740.3; AT2G20740. [Q940P5-3]
DR GeneID; 816603; -.
DR Gramene; AT2G20740.1; AT2G20740.1; AT2G20740. [Q940P5-1]
DR Gramene; AT2G20740.2; AT2G20740.2; AT2G20740. [Q940P5-2]
DR Gramene; AT2G20740.3; AT2G20740.3; AT2G20740. [Q940P5-3]
DR KEGG; ath:AT2G20740; -.
DR Araport; AT2G20740; -.
DR TAIR; locus:2051348; AT2G20740.
DR eggNOG; ENOG502QWK6; Eukaryota.
DR HOGENOM; CLU_055730_2_0_1; -.
DR InParanoid; Q940P5; -.
DR OMA; FDICKWI; -.
DR OrthoDB; 1170162at2759; -.
DR PhylomeDB; Q940P5; -.
DR PRO; PR:Q940P5; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q940P5; baseline and differential.
DR Genevisible; Q940P5; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR PANTHER; PTHR19282; PTHR19282; 1.
DR Pfam; PF00335; Tetraspanin; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix; Vacuole.
FT CHAIN 1..221
FT /note="Tetraspanin-19"
FT /id="PRO_0000421059"
FT TOPO_DOM 1..14
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 36..53
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 75..88
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 110..140
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..221
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 174
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C5W7"
FT VAR_SEQ 1..90
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_045059"
FT VAR_SEQ 1..41
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_045060"
SQ SEQUENCE 221 AA; 24656 MW; 6FD7656A45CC081F CRC64;
MVRIVRSCLQ SMLKLVNSLI GMVGIAMILY AVWLIRQWQE QMGNLPFADS DHPVPWFIYS
FLGLGAILCV VTCAGHIAAE TVNGCCLYLY MGFIVLLTMV EGGVVADIFL NRDWKKDFPE
DPSGAFHQFS KFIESNFKIC KWIGLSIVCV QGLSVLIAML LKALGPHPHR HYDSDDEYNV
STVALLQDAR QPPPYVVGEP MYGAKPGAWT VRLMKGQTGE R
