TET2_ARATH
ID TET2_ARATH Reviewed; 270 AA.
AC Q9ZUN5;
DT 06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Tetraspanin-2;
GN Name=TET2; OrderedLocusNames=At2g19580; ORFNames=F3P11.18;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Kim C.J., Chen H., Cheuk R.F., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in the regulation of cell differentiation.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR EMBL; AC005917; AAD10165.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC06897.1; -; Genomic_DNA.
DR EMBL; BT011213; AAR92249.1; -; mRNA.
DR EMBL; BT012532; AAS99676.1; -; mRNA.
DR EMBL; AK229021; BAF00907.1; -; mRNA.
DR PIR; E84578; E84578.
DR RefSeq; NP_179548.1; NM_127516.4.
DR AlphaFoldDB; Q9ZUN5; -.
DR BioGRID; 1832; 32.
DR IntAct; Q9ZUN5; 32.
DR STRING; 3702.AT2G19580.1; -.
DR iPTMnet; Q9ZUN5; -.
DR PaxDb; Q9ZUN5; -.
DR PRIDE; Q9ZUN5; -.
DR ProteomicsDB; 226626; -.
DR EnsemblPlants; AT2G19580.1; AT2G19580.1; AT2G19580.
DR GeneID; 816477; -.
DR Gramene; AT2G19580.1; AT2G19580.1; AT2G19580.
DR KEGG; ath:AT2G19580; -.
DR Araport; AT2G19580; -.
DR TAIR; locus:2050354; AT2G19580.
DR eggNOG; ENOG502QUE2; Eukaryota.
DR HOGENOM; CLU_066970_0_0_1; -.
DR InParanoid; Q9ZUN5; -.
DR OMA; NPILWIN; -.
DR OrthoDB; 1166716at2759; -.
DR PhylomeDB; Q9ZUN5; -.
DR PRO; PR:Q9ZUN5; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9ZUN5; baseline and differential.
DR Genevisible; Q9ZUN5; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009506; C:plasmodesma; IBA:GO_Central.
DR GO; GO:0009734; P:auxin-activated signaling pathway; IEA:InterPro.
DR InterPro; IPR044991; TET_plant.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR PANTHER; PTHR32191; PTHR32191; 2.
DR Pfam; PF00335; Tetraspanin; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..270
FT /note="Tetraspanin-2"
FT /id="PRO_0000421042"
FT TOPO_DOM 1..8
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 30..42
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 64..74
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 96..232
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..270
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 270 AA; 30128 MW; C5534AF35B1C7729 CRC64;
MALANNLTAI LNLLALLCSI PITASGIWLA SKPDNECVNL LRWPVVVLGV LILVVSATGF
IGAYKYKETL LAVYLCCMAI LIGLLLVVLI FAFVVTRPDG SYRVPGRGYK EYRLEGFSNW
LKENVVDSKN WGRLRACLAD TNVCPKLNQE FITADQFFSS SKITPLQSGC CKPPTACGYN
FVNPTLWLNP TNMAADADCY LWSNDQSQLC YNCNSCKAGL LGNLRKEWRK ANLILIITVV
VLIWVYVIAC SAFRNAQTED LFRKYKQGWV
