ID   TET4_ARATH              Reviewed;         327 AA.
AC   Q9LSS4;
DT   06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Tetraspanin-4;
GN   Name=TET4; OrderedLocusNames=At5g60220; ORFNames=F15L12.11;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RA   Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL   Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
CC   -!- FUNCTION: May be involved in the regulation of cell differentiation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR   EMBL; AB026632; BAA97503.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED97295.1; -; Genomic_DNA.
DR   RefSeq; NP_200830.1; NM_125415.2.
DR   AlphaFoldDB; Q9LSS4; -.
DR   PaxDb; Q9LSS4; -.
DR   PRIDE; Q9LSS4; -.
DR   ProteomicsDB; 232744; -.
DR   EnsemblPlants; AT5G60220.1; AT5G60220.1; AT5G60220.
DR   GeneID; 836144; -.
DR   Gramene; AT5G60220.1; AT5G60220.1; AT5G60220.
DR   KEGG; ath:AT5G60220; -.
DR   Araport; AT5G60220; -.
DR   TAIR; locus:2144050; AT5G60220.
DR   eggNOG; ENOG502QU76; Eukaryota.
DR   HOGENOM; CLU_066970_0_0_1; -.
DR   InParanoid; Q9LSS4; -.
DR   OMA; ITIMVIS; -.
DR   OrthoDB; 1023323at2759; -.
DR   PhylomeDB; Q9LSS4; -.
DR   PRO; PR:Q9LSS4; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9LSS4; baseline and differential.
DR   Genevisible; Q9LSS4; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009506; C:plasmodesma; IBA:GO_Central.
DR   GO; GO:0009734; P:auxin-activated signaling pathway; IEA:InterPro.
DR   InterPro; IPR044991; TET_plant.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   PANTHER; PTHR32191; PTHR32191; 1.
DR   Pfam; PF00335; Tetraspanin; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..327
FT                   /note="Tetraspanin-4"
FT                   /id="PRO_0000421044"
FT   TOPO_DOM        1..6
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        28..43
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        65..75
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        97..235
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        257..287
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        288..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        309..327
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        34
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        187
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   327 AA;  37178 MW;  505A06D6A2D39F8D CRC64;
     MRSRSNLIGL INFFTFLLSI PILGGGIWLS SRANSTDCLR FLQWPLIIIG ISIMVISLAG
     IAGACYQNKF LMWLYLFTMF FVIAALIGFT IFAYVVTDKG SGRFVMNRRY LDYYLNDYSG
     WLKDRVTDNG YWRDIGSCVR DSGVCKKIGR DLNGVPETAH MFYFRNLSPV ESGCCKPPTD
     CGYTYVNETV WIPGGEMVGP NPDCMLWNND QRLLCYQCSS CKAGVLGSLK KSWRKVSVIN
     IVVVIILVIF YVIACAAYQN VKRMYNDEPV GEARMTNLIL VIFKFKEILV QFFFGIVFLL
     LFNGLMVCCC NDKFAFSVFF FGYVTYA