TET5B_BOVIN
ID TET5B_BOVIN Reviewed; 430 AA.
AC Q29RH2;
DT 14-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Terminal nucleotidyltransferase 5B {ECO:0000250|UniProtKB:Q96A09};
DE EC=2.7.7.19 {ECO:0000250|UniProtKB:Q96A09};
DE AltName: Full=Non-canonical poly(A) polymerase FAM46B;
GN Name=TENT5B {ECO:0000250|UniProtKB:Q96A09};
GN Synonyms=FAM46B {ECO:0000250|UniProtKB:Q96A09};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Heart ventricle;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the transfer of one adenosine molecule from an ATP
CC to an mRNA poly(A) tail bearing a 3'-OH terminal group in an ATP
CC hydrolysis-dependent manner. May be involved in maintaining the
CC translation efficiency of at least some genes through preventing
CC degradation of their mRNAs. Prefers RNA molecules that are adenosine-
CC rich close to 3'-end. In addition, may inhibit cell proliferation and
CC cell cycle progression through ubiquitination of beta-catenin/CTNNB1.
CC {ECO:0000250|UniProtKB:Q96A09}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide;
CC Xref=Rhea:RHEA:11332, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17347,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:140395,
CC ChEBI:CHEBI:173115; EC=2.7.7.19;
CC Evidence={ECO:0000250|UniProtKB:Q96A09};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11333;
CC Evidence={ECO:0000250|UniProtKB:Q96A09};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96A09}. Nucleus
CC {ECO:0000250|UniProtKB:Q96A09}.
CC -!- SIMILARITY: Belongs to the TENT family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-2 is the initiator.
CC {ECO:0000305}.
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DR EMBL; BC114174; AAI14175.1; -; mRNA.
DR RefSeq; NP_001039415.1; NM_001045950.1.
DR AlphaFoldDB; Q29RH2; -.
DR SMR; Q29RH2; -.
DR STRING; 9913.ENSBTAP00000024500; -.
DR PaxDb; Q29RH2; -.
DR PRIDE; Q29RH2; -.
DR Ensembl; ENSBTAT00000024500; ENSBTAP00000024500; ENSBTAG00000018413.
DR GeneID; 506745; -.
DR KEGG; bta:506745; -.
DR CTD; 115572; -.
DR VEuPathDB; HostDB:ENSBTAG00000018413; -.
DR VGNC; VGNC:28816; TENT5B.
DR eggNOG; KOG3852; Eukaryota.
DR GeneTree; ENSGT00940000160747; -.
DR HOGENOM; CLU_008115_2_0_1; -.
DR InParanoid; Q29RH2; -.
DR OMA; TTVNYYV; -.
DR OrthoDB; 612201at2759; -.
DR TreeFam; TF315239; -.
DR Proteomes; UP000009136; Chromosome 2.
DR Bgee; ENSBTAG00000018413; Expressed in surface of tongue and 100 other tissues.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0004652; F:polynucleotide adenylyltransferase activity; ISS:UniProtKB.
DR GO; GO:1990817; F:RNA adenylyltransferase activity; IBA:GO_Central.
DR GO; GO:0048255; P:mRNA stabilization; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR GO; GO:0045786; P:negative regulation of cell cycle; ISS:UniProtKB.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0045727; P:positive regulation of translation; ISS:UniProtKB.
DR InterPro; IPR012937; TET5.
DR PANTHER; PTHR12974; PTHR12974; 1.
DR Pfam; PF07984; NTP_transf_7; 1.
DR SMART; SM01153; DUF1693; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleotidyltransferase; Nucleus; Reference proteome;
KW Transferase.
FT CHAIN 1..430
FT /note="Terminal nucleotidyltransferase 5B"
FT /id="PRO_0000259930"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 430 AA; 47097 MW; 46ADDC2E127B5F74 CRC64;
MMPSESETES RDRAAAQVGT AAAAAVAKAA PAGGGPDPEA SSASLGQHLS GLSWPQVKRL
DALLSEPIPI HGRGNFPTLS VQPRQIVQVV RSSLEEQGLR VHGVRLHGSA ASHVLHPESG
LGYKDLDLVF RVDLRSEASF QLTKEVVLAC LLDFLPAGVS RAKITPLTLK EAYVQKLVKV
CTDTDRWSLI SLSNKSGKNV ELKFVDSVRR QFEFSVDSFQ ILLDSLLLFS QCSPTPMSEA
FHPSVTGESL YGDFAEALDH LRHRVIATRS PEEIRGGGLL KYCHLLVRGF RPRPSTDVGA
LQRYMCSRFF IDFPDLVEQR RTLERYLEAH FSGADAARRY ACLVTLHRVV NESTVCLMNH
ERRQTLDLIT ALALQALAEQ GPAAAAALAW RCPAIPDGLV PATTVSYYVT PVQPLLARAH
ASYPTWLPCN