ID   TET5C_CHICK             Reviewed;         390 AA.
AC   Q5ZL95;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Terminal nucleotidyltransferase 5C {ECO:0000305};
DE            EC=2.7.7.19 {ECO:0000250|UniProtKB:Q5VWP2};
GN   Name=TENT5C {ECO:0000250|UniProtKB:Q5VWP2};
GN   Synonyms=FAM46C {ECO:0000250|UniProtKB:Q5VWP2};
GN   ORFNames=RCJMB04_7b16 {ECO:0000303|PubMed:15642098};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Catalyzes the transfer of one adenosine molecule from an ATP
CC       to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances
CC       mRNA stability and gene expression. {ECO:0000250|UniProtKB:Q5VWP2}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide;
CC         Xref=Rhea:RHEA:11332, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17347,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:140395,
CC         ChEBI:CHEBI:173115; EC=2.7.7.19;
CC         Evidence={ECO:0000250|UniProtKB:Q5VWP2};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11333;
CC         Evidence={ECO:0000250|UniProtKB:Q5VWP2};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5VWP2}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q5VWP2}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome {ECO:0000250|UniProtKB:Q5VWP2}.
CC   -!- SIMILARITY: Belongs to the TENT family. {ECO:0000305}.
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DR   EMBL; AJ719839; CAG31498.1; -; mRNA.
DR   RefSeq; NP_001007973.1; NM_001007972.1.
DR   RefSeq; XP_015150068.1; XM_015294582.1.
DR   AlphaFoldDB; Q5ZL95; -.
DR   SMR; Q5ZL95; -.
DR   STRING; 9031.ENSGALP00000023291; -.
DR   PaxDb; Q5ZL95; -.
DR   GeneID; 426544; -.
DR   KEGG; gga:426544; -.
DR   CTD; 426544; -.
DR   VEuPathDB; HostDB:geneid_426544; -.
DR   eggNOG; KOG3852; Eukaryota.
DR   HOGENOM; CLU_008115_2_0_1; -.
DR   InParanoid; Q5ZL95; -.
DR   OrthoDB; 612201at2759; -.
DR   PhylomeDB; Q5ZL95; -.
DR   PRO; PR:Q5ZL95; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0004652; F:polynucleotide adenylyltransferase activity; ISS:UniProtKB.
DR   GO; GO:1990817; F:RNA adenylyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0048255; P:mRNA stabilization; ISS:UniProtKB.
DR   GO; GO:0045596; P:negative regulation of cell differentiation; ISS:UniProtKB.
DR   InterPro; IPR012937; TET5.
DR   PANTHER; PTHR12974; PTHR12974; 1.
DR   Pfam; PF07984; NTP_transf_7; 1.
DR   SMART; SM01153; DUF1693; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Nucleotidyltransferase; Nucleus;
KW   Reference proteome; RNA-binding; Transferase.
FT   CHAIN           1..390
FT                   /note="Terminal nucleotidyltransferase 5C"
FT                   /id="PRO_0000259937"
SQ   SEQUENCE   390 AA;  44752 MW;  4C478EF5B8818364 CRC64;
     MASKGSNTDC MSCSVLNWEQ VSRLHEVLTE VVPIHGRGNF PTLKITLKDI VQTVRSRLNE
     AGIAVHDVRL NGSAAGHVLV KDNGLGCKDL DLIFQVSLPS EAEFQLVRDV VLRSLLNFLP
     EGVSKLKISP VTLKEAYIQK LVKVSTESDR WSLISLSNKH GRNVELKFVD CIRRQFEFSV
     DSFQIILDSL LFYYDYSENP MSEHFHPTVI GESMYGDFEA AFDHLQNKLI ATKNPEEIRG
     GGLLKYSNLL VRDFRPMDKD EIKTLERYMC SRFFIDFPDI LDQQRKLETY LQNHFSKEER
     SKYDYLMILR RVVNESTVCL MGHERRQTLN LISLLALKVL AEQNIIPNAT TVTCYYQPAP
     YVSDVNFSNY YLANPPVPYS QSYPTWLPCN