ID   TET5C_RAT               Reviewed;         391 AA.
AC   Q5XIV0;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Terminal nucleotidyltransferase 5C {ECO:0000305};
DE            EC=2.7.7.19 {ECO:0000250|UniProtKB:Q5VWP2};
GN   Name=Tent5c {ECO:0000312|RGD:1359446};
GN   Synonyms=Fam46c {ECO:0000312|RGD:1359446};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Catalyzes the transfer of one adenosine molecule from an ATP
CC       to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances
CC       mRNA stability and gene expression. Can also elongate RNA oligos ending
CC       with uridine molecule, provided that the sequence is adenosine-rich.
CC       Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein.
CC       {ECO:0000250|UniProtKB:Q5VWP2}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide;
CC         Xref=Rhea:RHEA:11332, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17347,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:140395,
CC         ChEBI:CHEBI:173115; EC=2.7.7.19;
CC         Evidence={ECO:0000250|UniProtKB:Q5VWP2};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11333;
CC         Evidence={ECO:0000250|UniProtKB:Q5VWP2};
CC   -!- SUBUNIT: Interacts with BCCIP and PABPC1; the interaction has no effect
CC       on TENT5C poly(A) polymerase function. Interacts with PLK4; this
CC       interaction leads to the TENT5C recruitment into the centrosome.
CC       {ECO:0000250|UniProtKB:Q5VWP2}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5VWP2}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q5VWP2}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome {ECO:0000250|UniProtKB:Q5VWP2}.
CC       Note=Recruited into the centrosome through its interaction with PLK4.
CC       {ECO:0000250|UniProtKB:Q5VWP2}.
CC   -!- SIMILARITY: Belongs to the TENT family. {ECO:0000305}.
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DR   EMBL; BC083570; AAH83570.1; -; mRNA.
DR   RefSeq; NP_001014063.1; NM_001014041.1.
DR   RefSeq; XP_006233100.1; XM_006233038.3.
DR   AlphaFoldDB; Q5XIV0; -.
DR   SMR; Q5XIV0; -.
DR   IntAct; Q5XIV0; 1.
DR   STRING; 10116.ENSRNOP00000020401; -.
DR   PhosphoSitePlus; Q5XIV0; -.
DR   PaxDb; Q5XIV0; -.
DR   PRIDE; Q5XIV0; -.
DR   Ensembl; ENSRNOT00000097284; ENSRNOP00000077686; ENSRNOG00000070242.
DR   Ensembl; ENSRNOT00000098405; ENSRNOP00000096421; ENSRNOG00000070242.
DR   Ensembl; ENSRNOT00000103060; ENSRNOP00000080921; ENSRNOG00000070242.
DR   Ensembl; ENSRNOT00000108426; ENSRNOP00000081945; ENSRNOG00000070242.
DR   Ensembl; ENSRNOT00000116221; ENSRNOP00000093669; ENSRNOG00000070242.
DR   GeneID; 310721; -.
DR   KEGG; rno:310721; -.
DR   UCSC; RGD:1359446; rat.
DR   CTD; 54855; -.
DR   RGD; 1359446; Tent5c.
DR   eggNOG; KOG3852; Eukaryota.
DR   GeneTree; ENSGT00940000158856; -.
DR   HOGENOM; CLU_008115_2_0_1; -.
DR   InParanoid; Q5XIV0; -.
DR   OMA; NTRDCMS; -.
DR   OrthoDB; 612201at2759; -.
DR   PhylomeDB; Q5XIV0; -.
DR   TreeFam; TF315239; -.
DR   PRO; PR:Q5XIV0; -.
DR   Proteomes; UP000002494; Chromosome 2.
DR   Bgee; ENSRNOG00000015222; Expressed in testis and 18 other tissues.
DR   Genevisible; Q5XIV0; RN.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0004652; F:polynucleotide adenylyltransferase activity; ISS:UniProtKB.
DR   GO; GO:1990817; F:RNA adenylyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0001701; P:in utero embryonic development; ISO:RGD.
DR   GO; GO:0048255; P:mRNA stabilization; ISS:UniProtKB.
DR   GO; GO:0045596; P:negative regulation of cell differentiation; ISS:UniProtKB.
DR   InterPro; IPR012937; TET5.
DR   PANTHER; PTHR12974; PTHR12974; 1.
DR   Pfam; PF07984; NTP_transf_7; 1.
DR   SMART; SM01153; DUF1693; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Nucleotidyltransferase; Nucleus;
KW   Reference proteome; RNA-binding; Transferase.
FT   CHAIN           1..391
FT                   /note="Terminal nucleotidyltransferase 5C"
FT                   /id="PRO_0000259936"
SQ   SEQUENCE   391 AA;  44799 MW;  EDEC539DF06DF8AD CRC64;
     MADEGSSTKD SESFSVLNWD QVSRLHEVLT EVVPIHGRGN FPTLEITLKD IVQTVRSRLE
     EAGIKVQDVR LNGSAAGHVL VKDNGLGCKD LDLIFHVALP TEAEFQLVRD VVLCSLLNFL
     PEGVNKLKIS PVTLKEAYVQ KLVKVCTDTD RWSLISLSNK NGRNVELKFV DSIRRQFEFS
     VDSFQIILDS LLFFYDCSSN PVSEHFHPTV VGESMYGDFE EAFDHLQNRL IATKNPEEIR
     GGGLLKYSNL LVRDFRPADQ EEIKTLERYM CSRFFIDFPD ILEQQRKLET YLQNHFADEE
     RSKYDYLMIL RRVVNESTVC LMGHERRQTL NLISLLALRV LAEQNIIPSA TNVTCYYQPA
     PYVSDGNFNN YYIAHPPVTY SQPYPTWLPC N