ID   TET5_ENTFL              Reviewed;         639 AA.
AC   P11131;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Tetracycline resistance protein TetM from transposon Tn1545;
DE            Short=TetM(1545);
GN   Name=tetM; Synonyms=tet(M);
OS   Enterococcus faecalis (Streptococcus faecalis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=1351;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BM4127; TRANSPOSON=Tn1545;
RX   PubMed=3020504; DOI=10.1093/nar/14.17.7047;
RA   Martin P., Trieu-Cuot P., Courvalin P.;
RT   "Nucleotide sequence of the tetM tetracycline resistance determinant of the
RT   streptococcal conjugative shuttle transposon Tn1545.";
RL   Nucleic Acids Res. 14:7047-7058(1986).
CC   -!- FUNCTION: Abolishes the inhibitory effect of tetracyclin on protein
CC       synthesis by a non-covalent modification of the ribosomes.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. TetM/TetO
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU01059}.
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DR   EMBL; X04388; CAA27977.1; -; Genomic_DNA.
DR   PIR; A24333; A24333.
DR   RefSeq; WP_004632336.1; NG_048212.1.
DR   AlphaFoldDB; P11131; -.
DR   SMR; P11131; -.
DR   STRING; 1201292.DR75_1047; -.
DR   eggNOG; COG0480; Bacteria.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   GO; GO:0006412; P:translation; IEA:UniProtKB-KW.
DR   CDD; cd03711; Tet_C; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR041095; EFG_II.
DR   InterPro; IPR035647; EFG_III/V.
DR   InterPro; IPR000640; EFG_V-like.
DR   InterPro; IPR031157; G_TR_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR   InterPro; IPR035650; Tet_C.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR   Pfam; PF00679; EFG_C; 1.
DR   Pfam; PF14492; EFG_III; 1.
DR   Pfam; PF03764; EFG_IV; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   PRINTS; PR00315; ELONGATNFCT.
DR   SMART; SM00889; EFG_IV; 1.
DR   SUPFAM; SSF50447; SSF50447; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF54980; SSF54980; 2.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS00301; G_TR_1; 1.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; GTP-binding; Nucleotide-binding;
KW   Protein biosynthesis; Transposable element.
FT   CHAIN           1..639
FT                   /note="Tetracycline resistance protein TetM from transposon
FT                   Tn1545"
FT                   /id="PRO_0000091495"
FT   DOMAIN          1..242
FT                   /note="tr-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01059"
FT   BINDING         10..17
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         74..78
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         128..131
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   639 AA;  72658 MW;  2F7A3CD0588253CE CRC64;
     MKIINIGVLA HVDAGKTTLT ESLLYNSGAI TELGSVDRGT TKTDNTLLER QRGITIQTAI
     TSFQWKNTKV NIIDTPGHMD FLAEVYRSLS VLDGAILLIS AKDGVQAQTR ILFHALRKIG
     IPTIFFINKI DQNGIDLSTV YQDIKEKLSA EIVIKQKVEL HPNMRVMNFT ESEQWDMVIE
     GNDYLLEKYT SGKLLEALEL EQEESIRFHN CSLFPVYHGS AKNNIGIDNL IEVITNKFYS
     STHRGQSELC GKVFKIEYSE KRQRLAYIRL YSGVLHLRDP VRISEKEKIK ITEMYTSING
     ELCKIDKAYS GEIVILQNEF LKLNSVLGDT KLLPQRERIE NPLPLLQTTV EPSKPQQREM
     LLDALLEISD SDPLLRYYVD SATHEIILSF LGKVQMEVTC ALLQEKYHVE IEIKEPTVIY
     MERPLKKAEY TIHIEVPPNP FWASIGLSVA PLPLGSGVQY ESSVSLGYLN QSFQNAVMEG
     IRYGCEQGLY GWNVTDCKIC FKYGLYYSPV STPADFRMLA PIVLEQVLKK AGTELLEPYL
     SFKIYAPQEY LSRAYNDAPK YCANIVDTQL KNNEVILSGE IPARCIQEYR SDLTFFTNGR
     SVCLTELKGY HVTTGEPVCQ PRRPNSRIDK VRYMFNKIT