TET8_ARATH
ID TET8_ARATH Reviewed; 273 AA.
AC Q8S8Q6; O64822; Q683G1; Q8S8N8;
DT 06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Tetraspanin-8;
GN Name=TET8; OrderedLocusNames=At2g23810; ORFNames=F27L4.1;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 79-273.
RC STRAIN=cv. Columbia;
RA Southwick A., Karlin-Neumann G., Nguyen M., Lam B., Miranda M., Palm C.J.,
RA Theologis A., Ecker J., Davis R.W.;
RL Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 79-273.
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Carninci P., Hayashizaki Y.,
RA Ishida J., Kamiya A., Kawai J., Narusaka M., Sakurai T., Satou M., Seki M.,
RA Shinozaki K., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in the regulation of cell differentiation.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF18611.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC004482; AAM14957.1; -; Genomic_DNA.
DR EMBL; AC005170; AAF18611.2; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC07493.1; -; Genomic_DNA.
DR EMBL; AK175156; BAD42919.1; -; mRNA.
DR EMBL; AF325069; AAK17137.1; -; mRNA.
DR EMBL; BT010635; AAQ89657.1; -; mRNA.
DR PIR; T02338; T02338.
DR RefSeq; NP_850045.2; NM_179714.5.
DR AlphaFoldDB; Q8S8Q6; -.
DR STRING; 3702.AT2G23810.1; -.
DR SwissPalm; Q8S8Q6; -.
DR PaxDb; Q8S8Q6; -.
DR PRIDE; Q8S8Q6; -.
DR ProteomicsDB; 232825; -.
DR EnsemblPlants; AT2G23810.1; AT2G23810.1; AT2G23810.
DR GeneID; 816913; -.
DR Gramene; AT2G23810.1; AT2G23810.1; AT2G23810.
DR KEGG; ath:AT2G23810; -.
DR Araport; AT2G23810; -.
DR TAIR; locus:2048982; AT2G23810.
DR eggNOG; ENOG502QQQH; Eukaryota.
DR HOGENOM; CLU_066970_0_0_1; -.
DR InParanoid; Q8S8Q6; -.
DR OMA; AGCCKPS; -.
DR OrthoDB; 1209030at2759; -.
DR PhylomeDB; Q8S8Q6; -.
DR PRO; PR:Q8S8Q6; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q8S8Q6; baseline and differential.
DR Genevisible; Q8S8Q6; AT.
DR GO; GO:0005794; C:Golgi apparatus; HDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR GO; GO:0005773; C:vacuole; HDA:TAIR.
DR GO; GO:0009734; P:auxin-activated signaling pathway; IEA:InterPro.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEP:TAIR.
DR InterPro; IPR044991; TET_plant.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR018503; Tetraspanin_CS.
DR PANTHER; PTHR32191; PTHR32191; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PROSITE; PS00421; TM4_1; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..273
FT /note="Tetraspanin-8"
FT /id="PRO_0000421048"
FT TOPO_DOM 1..7
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..45
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 67..75
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 97..235
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..273
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 192
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 62
FT /note="I -> V (in Ref. 3; BAD42919)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 273 AA; 30658 MW; 36DA947B97FEDC82 CRC64;
MARCSNNLVG ILNFLVFLLS IPILAGGIWL SQKGSTECER FLDKPVIALG VFLMVVAIAG
LIGSCCRVTW LLWVYLFVMF LLILLVFCIT VFAFVVTNKG AGEAIEGKGY KEYKLGDYST
WLQKRVENGK NWNKIRSCLV ESKVCSKLEA KFVNVPVNSF YKEHLTALQS GCCKPSDECG
FEYVNPTTWT KNTTGTHTNP DCQTWDNAKE KLCFDCQSCK AGLLDNVKSA WKKVAIVNIV
FLVFLIIVYS VGCCAFRNNK RDDSYSRTYG YKP
