ID   TETC_ECOLX              Reviewed;         197 AA.
AC   P28815;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Transposon Tn10 TetC protein;
DE   AltName: Full=ORFL;
GN   Name=tetC;
OS   Escherichia coli.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6094471; DOI=10.1128/jb.160.2.499-503.1984;
RA   Schollmeier K., Hillen W.;
RT   "Transposon Tn10 contains two structural genes with opposite polarity
RT   between tetA and IS10R.";
RL   J. Bacteriol. 160:499-503(1984).
RN   [2]
RP   CHARACTERIZATION.
RX   PubMed=6094472; DOI=10.1128/jb.160.2.504-509.1984;
RA   Braus G., Argast M., Beck C.F.;
RT   "Identification of additional genes on transposon Tn10: tetC and tetD.";
RL   J. Bacteriol. 160:504-509(1984).
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DR   EMBL; J01830; AAB59095.1; -; Genomic_DNA.
DR   AlphaFoldDB; P28815; -.
DR   SMR; P28815; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Transcription; Transcription regulation; Transposable element.
FT   CHAIN           1..197
FT                   /note="Transposon Tn10 TetC protein"
FT                   /id="PRO_0000070621"
FT   DOMAIN          12..72
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        35..54
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   197 AA;  22718 MW;  3C72C5C1350E9351 CRC64;
     MENKNHQQEN FKSTYQSLVN SARILFVEKG YQAVSIDEIS GKALVTKGAF YHHFKNKKQL
     LSACYKQQLI MIDAYITTKT DLTNGWSALE SIFEHYLDYI IDNNKNLIPI QEVMPIIGWN
     ELEKISLEYI TGKVNAIVSK LIQENQLKAY DSDVLKNLLN GWFMHIAIHA KNLKELADKK
     GQFIAIYRGF LLSLKDK