ID   TETO_CAMJU              Reviewed;         639 AA.
AC   P10952;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2004, sequence version 2.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Tetracycline resistance protein TetO;
DE            Short=Tet(O);
GN   Name=tetO; Synonyms=tet(O);
OS   Campylobacter jejuni.
OG   Plasmid pUA466.
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=197;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2836268; DOI=10.1016/0378-1119(88)90576-8;
RA   Manavathu E.K., Hiratsuka K., Taylor D.E.;
RT   "Nucleotide sequence analysis and expression of a tetracycline-resistance
RT   gene from Campylobacter jejuni.";
RL   Gene 62:17-26(1988).
RN   [2]
RP   SEQUENCE REVISION TO 591 AND 636-639.
RA   Manavathu E.K., Hiratsuka K., Taylor D.E.;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Abolishes the inhibitory effect of tetracyclin on protein
CC       synthesis by a non-covalent modification of the ribosomes.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. TetM/TetO
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU01059}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M18896; AAA23033.2; -; Genomic_DNA.
DR   PIR; A29809; A29809.
DR   RefSeq; WP_002779752.1; NZ_SYTG01000001.1.
DR   PDB; 4V6V; EM; 9.80 A; A1=1-639.
DR   PDBsum; 4V6V; -.
DR   AlphaFoldDB; P10952; -.
DR   SMR; P10952; -.
DR   KEGG; ag:AAA23033; -.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   GO; GO:0006412; P:translation; IEA:UniProtKB-KW.
DR   CDD; cd03711; Tet_C; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR041095; EFG_II.
DR   InterPro; IPR035647; EFG_III/V.
DR   InterPro; IPR000640; EFG_V-like.
DR   InterPro; IPR031157; G_TR_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR   InterPro; IPR035650; Tet_C.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR   Pfam; PF00679; EFG_C; 1.
DR   Pfam; PF14492; EFG_III; 1.
DR   Pfam; PF03764; EFG_IV; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   PRINTS; PR00315; ELONGATNFCT.
DR   SMART; SM00889; EFG_IV; 1.
DR   SUPFAM; SSF50447; SSF50447; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF54980; SSF54980; 2.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS00301; G_TR_1; 1.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Antibiotic resistance; GTP-binding; Nucleotide-binding;
KW   Plasmid; Protein biosynthesis.
FT   CHAIN           1..639
FT                   /note="Tetracycline resistance protein TetO"
FT                   /id="PRO_0000091505"
FT   DOMAIN          1..244
FT                   /note="tr-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01059"
FT   BINDING         10..17
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         74..78
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         128..131
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   639 AA;  72563 MW;  2B5A48484E2CFA01 CRC64;
     MKIINLGILA HVDAGKTTLT ESLLYTSGAI AELGSVDEGT TRTDTMNLER QRGITIQTAV
     TSFQWEDVKV NIIDTPGHMD FLAEVYRSLS VLDGAVLLVS AKDGIQAQTR ILFHALQIMK
     IPTIFFINKI DQEGIDLPMV YREMKAKLSS EIIVKQKVGQ HPHINVTDND DMEQWDAVIM
     GNDELLEKYM SGKPFKMSEL EQEENRRFQN GTLFPVYHGS AKNNLGTRQL IEVIASKFYS
     STPEGQSELC GQVFKIEYSE KRRRFVYVRI YSGTLHLRDV IRISEKEKIK ITEMYVPTNG
     ELYSSDTACS GDIVILPNDV LQLNSILGNE ILLPQRKFIE NPLPMIQTTI AVKKSEQREI
     LLGALTEISD CDPLLKYYVD TTTHEIILSF LGNVQMEVIC AILEEKYHVE AEIKEPTVIY
     MERPLRKAEY TIHIEVPPNP FWASVGLSIE PLPIGSGVQY ESRVSLGYLN QSFQNAVMEG
     VLYGCEQGLY GWKVTDCKIC FEYGLYYSPV STPADFRLLS PIVLEQALKK AGTELLEPYL
     HFEIYAPQEY LSRAYHDAPR YCADIVSTQI KNDEVILKGE IPARCIQEYR NDLTYFTNGQ
     GVCLTELKGY QPAIGKFICQ PRRPNSRIDK VRHMFHKLA