ID   TETQ_BACFG              Reviewed;         641 AA.
AC   Q08425;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Tetracycline resistance protein TetQ;
DE   AltName: Full=TetA(Q)2;
GN   Name=tetQ; Synonyms=tet(Q);
OS   Bacteroides fragilis.
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=817;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=1126;
RX   PubMed=7916585; DOI=10.1128/aac.37.9.2037;
RA   Lepine G., Lacroix J.-M., Walker C.B., Progulske-Fox A.;
RT   "Sequencing of a tet(Q) gene isolated from Bacteroides fragilis 1126.";
RL   Antimicrob. Agents Chemother. 37:2037-2041(1993).
CC   -!- FUNCTION: Abolishes the inhibitory effect of tetracyclin on protein
CC       synthesis by a non-covalent modification of the ribosomes.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. TetM/TetO
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU01059}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA79727.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; Z21523; CAA79728.1; -; Genomic_DNA.
DR   EMBL; Z21523; CAA79727.1; ALT_INIT; Genomic_DNA.
DR   PIR; I40188; I40188.
DR   RefSeq; WP_002560998.1; NZ_SRKB01000002.1.
DR   AlphaFoldDB; Q08425; -.
DR   SMR; Q08425; -.
DR   GeneID; 66377474; -.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   GO; GO:0006412; P:translation; IEA:UniProtKB-KW.
DR   CDD; cd03711; Tet_C; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR041095; EFG_II.
DR   InterPro; IPR035647; EFG_III/V.
DR   InterPro; IPR000640; EFG_V-like.
DR   InterPro; IPR031157; G_TR_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR   InterPro; IPR035650; Tet_C.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR   Pfam; PF00679; EFG_C; 1.
DR   Pfam; PF14492; EFG_III; 1.
DR   Pfam; PF03764; EFG_IV; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   PRINTS; PR00315; ELONGATNFCT.
DR   SMART; SM00838; EFG_C; 1.
DR   SMART; SM00889; EFG_IV; 1.
DR   SUPFAM; SSF50447; SSF50447; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF54980; SSF54980; 2.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS00301; G_TR_1; 1.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; GTP-binding; Nucleotide-binding;
KW   Protein biosynthesis.
FT   CHAIN           1..641
FT                   /note="Tetracycline resistance protein TetQ"
FT                   /id="PRO_0000091510"
FT   DOMAIN          1..244
FT                   /note="tr-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01059"
FT   BINDING         10..17
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         74..78
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         128..131
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   641 AA;  72523 MW;  4754576D8FDD5347 CRC64;
     MNIINLGILA HIDAGKTSVT ENLLFASGAT EKCGRVDNGD TITDSMDIEK RRGITVRAST
     TSIIWNGVKC NIIDTPGHMD FIAEVERTFK MLDGAVLILS AKEGIQAQTK LLFNTLQKLQ
     IPTIIFINKI DRDGVNLERL YLDIKTNLSQ DVLFMQTVVD GLVYPICSQT YIKEEYKEFV
     CNHDDNILER YLADSEISPA DYWNTIIDLV AKAKVYPVLH GSAMFNIGIN ELLDAISSFI
     LPPESVSNRL SAYLYKIEHD PKGHKRSFLK IIDGSLRLRD IVRINDSEKF IKIKNLKTIY
     QGREINVDEV GANDIAIVED MEDFRIGDYL GTKPCLIQGL SHQHPALKSS VRPDRSEERS
     KVISALNTLW IEDPSLSFSI NSYSDELEIS LYGLTQKEII QTLLEERFSV KVHFDEIKTI
     YKERPVKKVN KIIQIEVPPN PYWATIGLTL EPLPLGTGLQ IESDISYGYL NHSFQNAVFE
     GIRMSCQSGL HGWEVTDLKV TFTQAEYYSP VSTPADFRQL TPYVFRLALQ QSGVDILEPM
     LYFELQIPQA ASSKAITDLQ KMMSEIEDIS CNNEWCHIKG KVPLNTSKDY ASEVSSYTKG
     LGVFMVKPCG YQITKGDYSD NIRMNEKDKL LFMFQKSMSS K