ID   TETQ_BACFR              Reviewed;         641 AA.
AC   P70882; Q799Y0;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 3.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Tetracycline resistance protein TetQ;
DE            Short=Tet(Q);
DE   AltName: Full=TetA(Q)3;
GN   Name=tetQ; OrderedLocusNames=BF0141;
OS   Bacteroides fragilis (strain YCH46).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=295405;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BF2;
RA   Reysset G.;
RL   Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YCH46;
RX   PubMed=15466707; DOI=10.1073/pnas.0404172101;
RA   Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N.,
RA   Kuhara S., Hattori M., Hayashi T., Ohnishi Y.;
RT   "Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions
RT   regulating cell surface adaptation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004).
CC   -!- FUNCTION: Abolishes the inhibitory effect of tetracyclin on protein
CC       synthesis by a non-covalent modification of the ribosomes.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. TetM/TetO
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU01059}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAD46890.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=CAA69906.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; Y08615; CAA69906.1; ALT_INIT; Genomic_DNA.
DR   EMBL; Y08615; CAA69907.1; -; Genomic_DNA.
DR   EMBL; AP006841; BAD46890.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_004291466.1; NC_006347.1.
DR   RefSeq; YP_097424.3; NC_006347.1.
DR   AlphaFoldDB; P70882; -.
DR   SMR; P70882; -.
DR   STRING; 295405.BF0141; -.
DR   EnsemblBacteria; BAD46890; BAD46890; BF0141.
DR   GeneID; 64352988; -.
DR   GeneID; 66751439; -.
DR   KEGG; bfr:BF0141; -.
DR   PATRIC; fig|295405.11.peg.172; -.
DR   HOGENOM; CLU_002794_4_2_10; -.
DR   OMA; GITIFSH; -.
DR   Proteomes; UP000002197; Chromosome.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   GO; GO:0006412; P:translation; IEA:UniProtKB-KW.
DR   CDD; cd03711; Tet_C; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR041095; EFG_II.
DR   InterPro; IPR035647; EFG_III/V.
DR   InterPro; IPR000640; EFG_V-like.
DR   InterPro; IPR031157; G_TR_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR   InterPro; IPR035650; Tet_C.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR   Pfam; PF00679; EFG_C; 1.
DR   Pfam; PF14492; EFG_III; 1.
DR   Pfam; PF03764; EFG_IV; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   PRINTS; PR00315; ELONGATNFCT.
DR   SMART; SM00838; EFG_C; 1.
DR   SMART; SM00889; EFG_IV; 1.
DR   SUPFAM; SSF50447; SSF50447; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF54980; SSF54980; 2.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS00301; G_TR_1; 1.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; GTP-binding; Nucleotide-binding;
KW   Protein biosynthesis.
FT   CHAIN           1..641
FT                   /note="Tetracycline resistance protein TetQ"
FT                   /id="PRO_0000091509"
FT   DOMAIN          1..244
FT                   /note="tr-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01059"
FT   BINDING         10..17
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         74..78
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         128..131
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   641 AA;  72222 MW;  D1270818E4199BF5 CRC64;
     MNIINLGILA HIDAGKTSVT ENLLFASGAT EKCGRVDNGD TITDSMDIEK RRGITVRAST
     TSIIWNGVKC NIIDTPGHMD FIAEVERTFK MLDGAVLILS AKEGIQAQTK LLFSTLQKLQ
     IPTIIFINKI DRAGVNLERL YMDIKTNLSQ DVLFMQTVVD GSVYPVCSQT YIKEEYKEFV
     CNHDDDILER YLADSEISPA DYWNTIIALV AKAKVYPVLH GSAMFNIGIN ELLDAISSFI
     LPPASVSNRL SAYLYKIEHD PKGHKRSFLK IIDGSLRLRD VVRINDSEKF IKIKNLKTIY
     QGREINVDEV GANDIAIVED IEDFRIGDYL GAKPCLIQGL SHQHPALKSS VRPNKPEERS
     KVISALNTLW IEDPSLSFSI NSYSDELEIS LYGLTQKEII QTLLEERFSV KVHFDEIKTI
     YKERPIKKVN KIIQIEVPPN PYWATIGLTL EPLPLGAGLQ IESDISYGYL NHSFQNAVFE
     GIRMSCQSGL HGWEVTDLKV TFTQAEYYSP VSTPADFRQL TPYVFRLALQ QSGVDILEPM
     LCFELQIPQV ASSKAITDLQ KLMSEIEDIS CNNEWCHIKG KVPLNTSKDY ASEVSSYTKG
     LGIFMVKPCG YQITKDGYSD NIRMNEKDKL LFMFQKSMSL K