ID   TETQ_PREIN              Reviewed;         654 AA.
AC   O05197;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-1998, sequence version 2.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Tetracycline resistance protein TetQ;
DE            Short=Tet(Q);
GN   Name=tetQ; Synonyms=tet(Q);
OS   Prevotella intermedia.
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Prevotellaceae;
OC   Prevotella.
OX   NCBI_TaxID=28131;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=PDRC-11;
RA   Bueno L.B., Presnail J.K., Walker C.B.;
RL   Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Abolishes the inhibitory effect of tetracyclin on protein
CC       synthesis by a non-covalent modification of the ribosomes.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. TetM/TetO
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU01059}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB51122.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; U73497; AAB51122.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_063856408.1; NG_048271.1.
DR   AlphaFoldDB; O05197; -.
DR   SMR; O05197; -.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   GO; GO:0006412; P:translation; IEA:UniProtKB-KW.
DR   CDD; cd03711; Tet_C; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR041095; EFG_II.
DR   InterPro; IPR035647; EFG_III/V.
DR   InterPro; IPR000640; EFG_V-like.
DR   InterPro; IPR031157; G_TR_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR   InterPro; IPR035650; Tet_C.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR   Pfam; PF00679; EFG_C; 1.
DR   Pfam; PF14492; EFG_III; 1.
DR   Pfam; PF03764; EFG_IV; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   PRINTS; PR00315; ELONGATNFCT.
DR   SMART; SM00838; EFG_C; 1.
DR   SMART; SM00889; EFG_IV; 1.
DR   SUPFAM; SSF50447; SSF50447; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF54980; SSF54980; 2.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS00301; G_TR_1; 1.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; GTP-binding; Nucleotide-binding;
KW   Protein biosynthesis.
FT   CHAIN           1..654
FT                   /note="Tetracycline resistance protein TetQ"
FT                   /id="PRO_0000091512"
FT   DOMAIN          1..244
FT                   /note="tr-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01059"
FT   BINDING         10..17
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         74..78
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         128..131
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   654 AA;  74132 MW;  653CF3D193C23A1C CRC64;
     MNIINLGILA HIDAGKTSVT ENLLFASGAT EKCGRVDNGD TITDSMDIEK RRGITVRAST
     TSIIWNGVKC NIIDTPGHMD FIAEVERTFK MLDGAVLILS AKEGIQAQTK LLFNTLQKLQ
     IPTIIFINKI DRDGVNLERL YLDIKTNLSQ DVLFMQTVVD GLVYPICSQT YIKEEYKEFV
     CNHDDNILER YLADSEISPA DYWNTIIDLV AKAKVYPVLH GSAMFNIGIN ELLDAISSFI
     LPPESVSNRL SAYLYKIEHD PKGHKRSFLK IIDGSLRLRD IVRINDSEKF IKIKNLKTIY
     QGRKINVDEV GANDIAIVED MEDFRIGDYL GTKPCLIQGL SHQHPALKSS VRPDRSEERS
     KVISALNTLW IEDPSLSFSI NSYSDELEIS LYGLTQKEII QTLLEERFSV KVHFDEIKTI
     YKERPVKKVN KIIQIEVPPN PYWATIGLTL EPLPLGTGLQ IESDISYGYL NHSFQNAVFE
     GIRMSCQSGL HGWEVTDLKV TFTQAEYYSP VSTPADFRQL TPYVFRLALQ QSGVDILEPM
     LYFELQIPQA ASSKAITDLQ KMMSEIEDIS CNNEWCHIKG KVPYNTSKDY ASEVSSYTKG
     LGVFMVKPCG YQITKGDYSD NIRMNEKDKI LFMFQKSNVI KIMERSGNFY KAIQ