ID   TETQ_PRERU              Reviewed;         641 AA.
AC   Q52360;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Tetracycline resistance protein TetQ;
DE            Short=Tet(Q);
GN   Name=tetQ;
OS   Prevotella ruminicola (Bacteroides ruminicola).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Prevotellaceae;
OC   Prevotella.
OX   NCBI_TaxID=839;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=223;
RX   PubMed=7944364; DOI=10.1128/aem.60.9.3255-3260.1994;
RA   Nikolich M.P., Hong G., Shoemaker N.B., Salyers A.A.;
RT   "Evidence for natural horizontal transfer of tetQ between bacteria that
RT   normally colonize humans and bacteria that normally colonize livestock.";
RL   Appl. Environ. Microbiol. 60:3255-3260(1994).
CC   -!- FUNCTION: Abolishes the inhibitory effect of tetracyclin on protein
CC       synthesis by a non-covalent modification of the ribosomes.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. TetM/TetO
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU01059}.
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DR   EMBL; L33696; AAA62400.1; -; Genomic_DNA.
DR   RefSeq; WP_063856407.1; NZ_FNUV01000012.1.
DR   AlphaFoldDB; Q52360; -.
DR   SMR; Q52360; -.
DR   KEGG; ag:AAA62400; -.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   GO; GO:0006412; P:translation; IEA:UniProtKB-KW.
DR   CDD; cd03711; Tet_C; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR041095; EFG_II.
DR   InterPro; IPR035647; EFG_III/V.
DR   InterPro; IPR000640; EFG_V-like.
DR   InterPro; IPR031157; G_TR_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR   InterPro; IPR035650; Tet_C.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR   Pfam; PF00679; EFG_C; 1.
DR   Pfam; PF14492; EFG_III; 1.
DR   Pfam; PF03764; EFG_IV; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   PRINTS; PR00315; ELONGATNFCT.
DR   SMART; SM00838; EFG_C; 1.
DR   SMART; SM00889; EFG_IV; 1.
DR   SUPFAM; SSF50447; SSF50447; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF54980; SSF54980; 2.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS00301; G_TR_1; 1.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; GTP-binding; Nucleotide-binding;
KW   Protein biosynthesis.
FT   CHAIN           1..641
FT                   /note="Tetracycline resistance protein TetQ"
FT                   /id="PRO_0000091513"
FT   DOMAIN          1..244
FT                   /note="tr-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01059"
FT   BINDING         10..17
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         74..78
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         128..131
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   641 AA;  72270 MW;  812330D9D7593D38 CRC64;
     MNIINLGILA HIDAGKTSVT ENLLFASGAT EKCGRVDNGD TITDSMDIEK RRGITVRAST
     TSIIWNGVKC NIIDTPGHMD FIAEVERTFK MLDGAVLILS AKEGIQAQTK LLFSTLQKLQ
     IPTIIFINKI DRAGVNLERL YMDIKTNLSQ DVLFMQTVVD GSVYPVCSQT YIKEEYKEFV
     CNHDDDILER YLADSEISPA DYWNTIIALV AKAKVYPVLH GSAMFNIGIN ELLDAITSFI
     LPPASVSNRL SAYLYKIEHD PKGHKRSFLK IIDGSLRLRD VVRINDSEKF IKIKNLKTIY
     QGREINVDEV GANDIAIVED IEDFRIGDYL GAKPCLIQGL SHQHPALKCS VRPNKPEERS
     KVISALNTLW IEDPSLSFSI NSYSDELEIS LYGLTQKEII QTLLEERFSV KVHFDEIKTI
     YKERPIKKVN KIIQIEVPPN PYWATIGLTL EPLPLGAGLQ IESDISYGYL NHSFQNAVFE
     GIRMSCQSGL HGWEVTDLKV TFTQAEYYSP VSTPADFRQL TPYVFRLALQ QSGVDILEPM
     LCFELQIPQV ASSKAITDLQ KMMSEIEDIS CNNEWCHIKG KVPLNTSKDY ASEVSSYTKG
     LGIFMVKPCG YQITKDGYSD NIRMNEKDKL LFMFQKSMSL K